NDAORALCAPSULE
Approved
Jun 1970
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
5/8 — Partial
MACRODANTIN (nitrofurantoin macrocrystals) by Almatica Pharma is mechanism of action the mechanism of the antimicrobial action of nitrofurantoin is unusual among antibacterials. Approved for urinary tract infections, enterococci, staphylococcus aureus and 4 more indications. First approved in 1970.
Drug data last refreshed 21h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MACRODANTIN is an oral nitrofuran antibiotic approved in 1970 for treatment of urinary tract infections caused by susceptible gram-negative and gram-positive bacteria including E. coli, Klebsiella, Enterobacter, and S. aureus. The drug works by being reduced to reactive intermediates that inhibit bacterial protein synthesis, energy metabolism, and nucleic acid synthesis, resulting in bactericidal activity in the urinary tract.
$0.025BPart D
LOE ApproachingDeclining
MACRODANTIN is in late lifecycle decline with minimal Part D spending ($25K in 2023, 106 claims), signaling a shrinking team and focus on maintenance rather than growth.
Mechanism of Action
Mechanism of Action The mechanism of the antimicrobial action of nitrofurantoin is unusual among antibacterials. Nitrofurantoin is reduced by bacterial flavoproteins to reactive intermediates which inactivate or alter bacterial ribosomal proteins and other acromolecules. As a result of such…
Pharmacologic Class:
Nitrofuran Antibacterial
Indications (7)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.