NDAORALTABLET
Approved
Jul 1989
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
ZESTORETIC (lisinopril and hydrochlorothiazide) by Almatica Pharma is mechanism of action lisinopril inhibits angiotensin-converting enzyme (ace) in human subjects and animals. Approved for hypertension, to lower blood pressure. First approved in 1989.
Drug data last refreshed 1h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ZESTORETIC is a fixed-dose combination of lisinopril (ACE inhibitor) and hydrochlorothiazide (thiazide diuretic) administered orally as a tablet. It treats hypertension by inhibiting angiotensin-converting enzyme to reduce vasoconstriction and aldosterone secretion, while the diuretic component increases sodium and water excretion. This dual mechanism provides synergistic blood pressure reduction with potassium-sparing benefits compared to monotherapy.
$0.883MPart D
LOE ApproachingDeclining
Product approaching loss of exclusivity with modest Medicare utilization signals declining team investment in marketing and sales support.
Mechanism of Action
Mechanism of Action Lisinopril inhibits angiotensin-converting enzyme (ACE) in human subjects and animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also stimulates aldosterone secretion by the…
Pharmacologic Class:
Thiazide Diuretic
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.