NDAORALTABLET
Approved
Jan 1980
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
VIBRA-TABS (doxycycline hyclate) by Pfizer is tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. Approved for gonorrhea, chlamydia, syphilis and 3 more indications. First approved in 1980.
Drug data last refreshed 19h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VIBRA-TABS (doxycycline hyclate) is an oral tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, delivering bacteriostatic activity against a broad range of Gram-positive and Gram-negative bacteria. It is indicated for sexually transmitted infections (gonorrhea, chlamydia, syphilis), acne vulgaris, and Helicobacter pylori infection. The drug is nearly completely absorbed orally with a serum half-life of 18–22 hours, independent of renal function.
LOE Approaching
As a mature, off-patent tetracycline approaching loss of exclusivity, VIBRA-TABS commercial teams are likely focused on brand defense and niche positioning rather than growth expansion.
Mechanism of Action
Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.