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Syphilis

5
Pipeline Programs
4
Companies
8
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
0
4
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

4 companies ranked by most advanced pipeline stage

UNION therapeutics
UNION therapeuticsDenmark - Hellerup
4 programs
3
Benzathine Penicillin GPhase 41 trial
Benzathine Penicillin GPhase 41 trial
benzathine penicillinPhase 41 trial
RPR TiterN/A1 trial
Active Trials
NCT03754517Unknown30Est. Dec 2019
NCT02857959Unknown150Est. Aug 2020
NCT02871505Unknown150Est. Aug 2020
+1 more trials
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
1
Benzathine PenicillinPhase 41 trial
Active Trials
NCT03637660Completed249Est. Mar 2023
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
1
Cefixime 400 milligram Oral Capsule [Suprax]Phase 21 trial
DoxycycylineN/A1 trial
Active Trials
NCT02257658Completed30Est. Jan 2013
NCT03660488Completed58Est. Jan 2021
Human BioSciences
Human BioSciencesWV - Martinsburg
1 program
Quantitative polymerase chain reactionN/A1 trial
Active Trials
NCT06082453Recruiting924Est. Nov 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Allergy TherapeuticsBenzathine Penicillin
UNION therapeuticsBenzathine Penicillin G
UNION therapeuticsbenzathine penicillin
UNION therapeuticsBenzathine Penicillin G
Angeles TherapeuticsCefixime 400 milligram Oral Capsule [Suprax]
Human BioSciencesQuantitative polymerase chain reaction
UNION therapeuticsRPR Titer
Angeles TherapeuticsDoxycycyline

Clinical Trials (8)

Total enrollment: 1,741 patients across 8 trials

NCT03637660Allergy TherapeuticsBenzathine Penicillin

Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection

Start: Oct 2018Est. completion: Mar 2023249 patients
Phase 4Completed
NCT02871505UNION therapeuticsBenzathine Penicillin G

The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings

Start: Aug 2016Est. completion: Aug 2020150 patients
Phase 4Unknown
NCT02884115UNION therapeuticsbenzathine penicillin

Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin

Start: Aug 2016Est. completion: Sep 2020150 patients
Phase 4Unknown
NCT02857959UNION therapeuticsBenzathine Penicillin G

One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis

Start: Aug 2016Est. completion: Aug 2020150 patients
Phase 4Unknown
NCT03660488Angeles TherapeuticsCefixime 400 milligram Oral Capsule [Suprax]

Cefixime for Alternative Syphilis Treatment

Start: Sep 2018Est. completion: Jan 202158 patients
Phase 2Completed
NCT06082453Human BioSciencesQuantitative polymerase chain reaction

Modernizing Perinatal Syphilis Testing

Start: May 2023Est. completion: Nov 2027924 patients
N/ARecruiting
NCT03754517UNION therapeuticsRPR Titer

Finding the Latent Treponema Pallidum

Start: Aug 2016Est. completion: Dec 201930 patients
N/AUnknown
NCT02257658Angeles TherapeuticsDoxycycyline

Efficacy of Doxycycline Prophylaxis to Reduce Syphilis in High-Risk, HIV-Positive MSM

Start: Sep 2011Est. completion: Jan 201330 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 1,741 patients
4 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.