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Gonorrhea

8
Pipeline Programs
8
Companies
12
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
3
0
1
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Vaccine
1100%
+ 15 programs with unclassified modality

On Market (1)

Approved therapies currently available

GSK
BLUJEPAApproved
gepotidacin
GSK
oral2025

Competitive Landscape

8 companies ranked by most advanced pipeline stage

Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
5 programs
1
1
Patient delivered partner therapyPhase 41 trial
Listerine Antiseptic Mouthwash ProductPhase 2
Gen-Probe APTIMA Combo2N/A1 trial
STD testingN/A1 trial
Standard Pay-it-forwardN/A1 trial
Active Trials
NCT00827697Completed399Est. Mar 2010
NCT02099760Completed402Est. Apr 2015
NCT05723263Completed1,200Est. Sep 2024
+1 more trials
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
1
Doxycycline hyclate delayed released 200 mgPhase 41 trial
Targeted STI ScreeningN/A
Active Trials
NCT06738407Not Yet Recruiting760Est. Jun 2028
GSK
GSKLONDON, United Kingdom
2 programs
1
GSK2140944PHASE_21 trial
GepotidacinPHASE_31 trial
Active Trials
NCT02294682Completed106Est. Jul 2016
NCT04010539Completed628Est. Oct 2023
ViiV Healthcare
ViiV HealthcareNC - Durham
2 programs
1
1
GepotidacinPhase 3
GSK2140944Phase 2
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
1
Listerine Antiseptic Mouthwash ProductPhase 21 trial
EPTN/A1 trial
Active Trials
NCT01720654Completed165Est. Aug 2014
NCT04966507Completed89Est. Dec 2025
Quotient Therapeutics
Quotient TherapeuticsMA - Cambridge
1 program
1
ZoliflodacinPhase 11 trial
Active Trials
NCT03718806Completed48Est. Nov 2018
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Targeted STI ScreeningN/A1 trial
Active Trials
NCT03715335Completed98,413Est. Jul 2025
Pfizer
PfizerNEW YORK, NY
1 program
Trumenba VaccineN/AVaccine1 trial
Active Trials
NCT05873751Completed1,307,378Est. Mar 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Human BioSciencesDoxycycline hyclate delayed released 200 mg
Allergy TherapeuticsPatient delivered partner therapy
GSKGepotidacin
Angeles TherapeuticsListerine Antiseptic Mouthwash Product
GSKGSK2140944
Quotient TherapeuticsZoliflodacin
PfizerTrumenba Vaccine
Allergy TherapeuticsStandard Pay-it-forward
Colorado TherapeuticsTargeted STI Screening
Allergy TherapeuticsSTD testing
Angeles TherapeuticsEPT
Allergy TherapeuticsGen-Probe APTIMA Combo2

Clinical Trials (12)

Total enrollment: 1,442,810 patients across 12 trials

NCT06738407Human BioSciencesDoxycycline hyclate delayed released 200 mg

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections

Start: Jan 2026Est. completion: Jun 2028760 patients
Phase 4Not Yet Recruiting
NCT01665690Allergy TherapeuticsPatient delivered partner therapy

Washington State Community Expedited Partner Treatment (EPT) Trial

Start: Jul 2007Est. completion: Aug 201133,222 patients
Phase 4Completed
NCT04010539GSKGepotidacin

A Study Evaluating Efficacy and Safety of Gepotidacin Compared With Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea

Start: Oct 2019Est. completion: Oct 2023628 patients
Phase 3Completed
NCT04966507Angeles TherapeuticsListerine Antiseptic Mouthwash Product

Antibacterial Mouthwash for Pharyngeal Gonorrhea Prevention

Start: Feb 2022Est. completion: Dec 202589 patients
Phase 2Completed
NCT02294682GSKGSK2140944

A Dose-Ranging Study Evaluating the Efficacy, Safety, and Tolerability of GSK2140944 in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria Gonorrhoeae

Start: Apr 2015Est. completion: Jul 2016106 patients
Phase 2Completed

Study to Investigate Effect of Food and Safety of a New Formulation of Zoliflodacin

Start: Oct 2018Est. completion: Nov 201848 patients
Phase 1Completed
NCT05873751PfizerTrumenba Vaccine

A Study to Learn About How Trumenba Vaccine Shots Work Against Gonorrhea Infection in Teenagers and Young Adults in the United States.

Start: Apr 2023Est. completion: Mar 20241,307,378 patients
N/ACompleted
NCT05723263Allergy TherapeuticsStandard Pay-it-forward

Pay-it-forward Gonorrhea and Chlamydia Testing Among Men in China

Start: Apr 2023Est. completion: Sep 20241,200 patients
N/ACompleted
NCT03715335Colorado TherapeuticsTargeted STI Screening

Adolescent Sexually Transmitted Infection Screening in the Emergency Department

Start: Jul 2020Est. completion: Jul 202598,413 patients
N/ACompleted

Cepheid Rectal Sample Validation Study

Start: Dec 2013Est. completion: Apr 2015402 patients
N/ACompleted

Expedited Partner Therapy for MSM in Peru

Start: Aug 2012Est. completion: Aug 2014165 patients
N/ACompleted
NCT00827697Allergy TherapeuticsGen-Probe APTIMA Combo2

A Validation Study for Detecting Chlamydia and Gonorrhea in Rectal Samples

Start: May 2009Est. completion: Mar 2010399 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
8 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.