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Helicobacter Pylori Infection

12
Pipeline Programs
11
Companies
15
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
7
1
1
0
2
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 15 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

EMS
EMSBrazil - Hortolândia
1 program
1
Food effectPhase 41 trial
Active Trials
NCT02552641Withdrawn0Est. Sep 2016
RedHill Biopharma
RedHill BiopharmaIsrael - Tel Aviv
1 program
1
RHB-105Phase 31 trial
Active Trials
NCT03198507Completed455Est. Dec 2018
Shandong Luoxin Pharmaceutical
1 program
1
TegoprazanPhase 31 trial
Active Trials
NCT05577468Completed561Est. Sep 2023
TenNor Therapeutics
TenNor TherapeuticsChina - Suzhou
8 programs
6
1
1
TNP-2198Phase 21 trial
TNP-2198Phase 1/21 trial
MidazolamPhase 11 trial
TNP-2092 capsulesPhase 11 trial
TNP-2092 capsulesPhase 11 trial
+3 more programs
Active Trials
NCT06551623Completed32Est. Oct 2024
NCT06190340Completed40Est. Sep 2017
NCT06337604Completed20Est. Nov 2017
+5 more trials
Sandoz
SandozAustria - Kundl
1 program
1
H.pylori vaccinesPhase 1
Erbe
ErbeGermany - Tübingen
1 program
HEAPEN/A1 trial
Active Trials
NCT06529159Recruiting20Est. Dec 2027
Chong Kun Dang Pharmaceutical
1 program
PantoprazoleN/ASmall Molecule1 trial
Active Trials
NCT02159976Completed390Est. Apr 2016
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
Saccharomyces boulardiiN/A1 trial
Active Trials
NCT03688828Completed360Est. Dec 2020
Phathom Pharmaceuticals
Phathom PharmaceuticalsFLORHAM PARK, NJ
1 program
VonoprazanPHASE_31 trial
Active Trials
NCT04167670Completed1,046Est. Mar 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
EMSFood effect
Shandong Luoxin PharmaceuticalTegoprazan
Phathom PharmaceuticalsVonoprazan
RedHill BiopharmaRHB-105
TenNor TherapeuticsTNP-2198
TenNor TherapeuticsTNP-2198
TenNor TherapeuticsMidazolam
TenNor Therapeutics[14C]TNP-2198
TenNor TherapeuticsTNP-2198
TenNor TherapeuticsTNP-2198
TenNor TherapeuticsTNP-2092 capsules
TenNor TherapeuticsTNP-2092 capsules
ErbeHEAPE
UNION therapeuticsSaccharomyces boulardii
Chong Kun Dang PharmaceuticalPantoprazole

Clinical Trials (15)

Total enrollment: 3,176 patients across 15 trials

NCT02552641EMSFood effect

Food Effect on the Eradication Rate of H. Pylori With Triple Therapy With Esomeprazole

Start: Sep 2015Est. completion: Sep 20160
Phase 4Withdrawn

Efficacy and Safety of Tegoprazan Versus Esomeprazole-containing Bismuth Quadruple Therapy for Eradication of Helicobacter Pylori

Start: Oct 2022Est. completion: Sep 2023561 patients
Phase 3Completed

Efficacy and Safety of Vonoprazan Compared to Lansoprazole in Participants With Helicobacter Pylori Infection

Start: Dec 2019Est. completion: Mar 20211,046 patients
Phase 3Completed

ERADICATE Hp2 - Treating Helicobacter Pylori With RHB-105 Compared to Active Comparator

Start: Jun 2017Est. completion: Dec 2018455 patients
Phase 3Completed

Efficacy and Safety After Multiple Doses of TNP-2198 Capsules, Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules in Helicobacter Pylori Infected-positive Participants

Start: Jun 2022Est. completion: Sep 202280 patients
Phase 2Completed

A Study to Evaluate Preliminary Helicobacter Pylori Eradication After Multiple Doses of TNP-2198 Capsules Combined With Rabeprazole Sodium Enteric-coated Tablets, or Rabeprazole Sodium Enteric-coated Tablets and Amoxicillin Capsules

Start: Sep 2021Est. completion: Jan 202240 patients
Phase 1/2Completed

Drug-Drug Interactions Between TNP-2198 and Midazolam, Clarithromycin

Start: Aug 2024Est. completion: Oct 202432 patients
Phase 1Completed

Human Mass Balance and Biotransformation Study of [14C]TNP-2198

Start: Jul 2022Est. completion: Sep 20226 patients
Phase 1Completed

A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of TNP-2198 Capsules in Asymptomatic Participants With Helicobacter Pylori Infection

Start: Oct 2020Est. completion: Jul 202148 patients
Phase 1Completed

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Food Effect of TNP-2198 Capsules After Single Oral Dose in Healthy Participants

Start: May 2019Est. completion: Sep 201978 patients
Phase 1Completed

The Safety and Tolerability, Pharmacokinetics of TNP-2092 Capsules in Combination With Rabeprazole Sodium Enteric-coated Tablets

Start: Oct 2017Est. completion: Nov 201720 patients
Phase 1Completed

A Phase 1 Study to Evaluate PK Profile of Multiple Oral Administrations of TNP-2092 Capsules in Healthy Subjects

Start: Nov 2016Est. completion: Sep 201740 patients
Phase 1Completed

H. Pylori Eradication With Argon Plasma During Endoscopy

Start: Jul 2025Est. completion: Dec 202720 patients
N/ARecruiting
NCT03688828UNION therapeuticsSaccharomyces boulardii

Evaluation of Saccharomyces Boulardii Combined With Standard Quadruple Therapy for Eradication of Helicobacter Pylori

Start: Nov 2018Est. completion: Dec 2020360 patients
N/ACompleted

Compare Sequential and Quadruple Therapy for the Eradication of Helicobacter Pylori in Korea

Start: Jul 2014Est. completion: Apr 2016390 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 3,176 patients
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.