Uveitis

Ophthalmology
9
Pipeline Programs
8
Companies
50
Clinical Trials
4 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
2
0
3
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
3100%
+ 5 programs with unclassified modality

On Market (1)

Approved therapies currently available

AbbVie
HUMIRAApproved
adalimumab
AbbVie
2002

Competitive Landscape

8 companies ranked by most advanced pipeline stage

AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
1
adalimumabPhase 3Monoclonal Antibody5 trials
Active Trials
NCT03938701Recruiting36Est. Aug 2026
NCT06100744Recruiting40Est. Oct 2028
NCT05814627Active Not Recruiting487Est. Jul 2026
+2 more trials
Bausch + Lomb
Bausch + LombNJ - Bridgewater
1 program
1
0.59 mg Fluocinolone Acetonide implantPhase 41 trial
Active Trials
NCT00543296Completed21Est. Jul 2007
Alder Therapeutics
Alder TherapeuticsSweden - Solna
1 program
1
AdalimumabPhase 4Monoclonal Antibody1 trial
Active Trials
NCT03816397Completed87Est. Apr 2025
Novartis
NovartisBASEL, Switzerland
1 program
1
AIN457Phase 31 trial
Active Trials
NCT01103024Withdrawn0Est. Feb 2011
ANI Pharmaceuticals
1 program
1
Yutiq 0.18 MG Drug ImplantPhase 31 trial
Active Trials
NCT05486468RecruitingEst. Dec 2026
Bristol Myers Squibb
1 program
1
AbataceptPhase 21 trial
Active Trials
NCT01279954Completed10Est. Jun 2017
S
SantenCA - Emeryville
1 program
1
Intravitreal injection 440mcgPhase 21 trial
Active Trials
NCT01280669WithdrawnEst. Dec 2024
Genentech
GenentechCA - Oceanside
1 program
1
RanibizumabPhase 1/2Monoclonal Antibody1 trial
Active Trials
NCT00498355Completed7Est. Dec 2009

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Alder TherapeuticsAdalimumab
AbbVieadalimumab
AbbVieadalimumab
AbbVieadalimumab
AbbVieadalimumab
AbbVieadalimumab
AbbVieadalimumab
AbbVieadalimumab
AbbVieadalimumab
AbbVieadalimumab
Bausch + Lomb0.59 mg Fluocinolone Acetonide implant
AbbVieadalimumab
AbbVieadalimumab
ANI PharmaceuticalsYutiq 0.18 MG Drug Implant
AbbVieadalimumab

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 8,158 patients across 50 trials

Adalimumab in JIA-associated Uveitis Stopping Trial

Start: Mar 2020Est. completion: Apr 202587 patients
Phase 4Completed

A Trial COmparing staNdard of Care Versus Treat to Target With telemonitoRing and Patient Education in Patients With Ulcerative cOlitis Initiating Adalimumab

Start: Jan 2020Est. completion: May 2028238 patients
Phase 4Recruiting

A Study Treating Participants With Early Axial Spondyloarthritis (axSpA) Taking an Intense Treatment Approach Versus Routine Treatment

Start: Sep 2016Est. completion: Dec 201722 patients
Phase 4Terminated

A Study of Subjects With Psoriatic Arthritis to Investigate the Effectiveness of Adalimumab Introduction Compared With Methotrexate Dose Escalation (CONTROL)

Start: Aug 2016Est. completion: Mar 2020246 patients
Phase 4Completed

Safety and Efficacy of Adalimumab (Humira) for Hidradenitis Suppurativa (HS) Peri-Surgically

Start: Jul 2016Est. completion: Oct 2019206 patients
Phase 4Completed

A Phase 4 Trial Assessing the ImPact of Residual Inflammation Detected Via Imaging TEchniques, Drug Levels and Patient Characteristics on the Outcome of Dose TaperIng of Adalimumab in Clinical Remission Rheumatoid ArThritis (RA) Subjects

Start: Jan 2015Est. completion: Aug 2018149 patients
Phase 4Completed

Targeted Ultrasound in Rheumatoid Arthritis

Start: Dec 2013Est. completion: Jul 2019183 patients
Phase 4Completed

Study of Adalimumab to Lower Cardiovascular Risk in RA Patients With Well Controlled Joint Disease

Start: Jul 2013Est. completion: Jul 201763 patients
Phase 4Completed

Bone Resorption, Osteoclastogenesis and Adalimumab

Start: May 2013Est. completion: Dec 2019120 patients
Phase 4Unknown

Vascular Inflammation in Psoriasis - Extension Study

Start: Apr 2013Est. completion: Oct 201681 patients
Phase 4Completed
NCT00543296Bausch + Lomb0.59 mg Fluocinolone Acetonide implant

Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment

Start: Mar 2004Est. completion: Jul 200721 patients
Phase 4Completed

A Study to Assess Adverse Events, Change in Disease Activity, and How the Drug Moves Through the Body in Children With Juvenile Psoriatic Arthritis (jPsA) Receiving Subcutaneously Injected Risankizumab or Adalimumab

Start: Jul 2024Est. completion: Oct 202840 patients
Phase 3Recruiting

Study to Assess Change in Disease Activity and Adverse Events of Oral Upadacitinib Compared to Subcutaneous Adalimumab in Adult Participants With Moderate to Severe Rheumatoid Arthritis

Start: Jun 2023Est. completion: Jul 2026487 patients
Phase 3Active Not Recruiting
NCT05486468ANI PharmaceuticalsYutiq 0.18 MG Drug Implant

The Use of Two YUTIQ Versus Sham for Treatment of Chronic Non Infectious Intraocular Inflammation Affecting the Posterior Segment

Start: Oct 2022Est. completion: Dec 2026
Phase 3Recruiting

A Study Comparing Upadacitinib (ABT-494) to Placebo and to Adalimumab in Participants With Psoriatic Arthritis Who Have an Inadequate Response to at Least One Non-Biologic Disease Modifying Anti-Rheumatic Drug (DMARD)

Start: Apr 2017Est. completion: Sep 20241,705 patients
Phase 3Completed

Open-label Study of Adalimumab in Japanese Subjects With Hidradenitis Suppurativa

Start: Sep 2016Est. completion: May 201915 patients
Phase 3Completed

Long-term Safety and Efficacy Study of Adalimumab in Pediatric Subjects With Ulcerative Colitis

Start: Nov 2015Est. completion: Apr 202559 patients
Phase 3Completed

Efficacy and Safety of Adalimumab in Pediatric Subjects With Moderate to Severe Ulcerative Colitis

Start: Oct 2014Est. completion: Feb 2020101 patients
Phase 3Completed

Open Label Study to Evaluate Long Term Efficacy, Safety and Tolerability of Repeated Dosing in Subjects With Crohn's Disease and Who Participated and Successfully Completed M14-115

Start: Aug 2014Est. completion: Nov 2017252 patients
Phase 3Completed

Concomitant Longitudinal Evaluation of Adalimumab With Methotrexate in the Real World: the CLEAR Study

Start: Aug 2014Est. completion: Mar 201746 patients
Phase 3Completed

Study to Evaluate Efficacy and Safety of Two Drug Regimens in Subjects With Moderate to Severe Crohn's Disease

Start: May 2014Est. completion: Jan 2020514 patients
Phase 3Completed

A Study to Evaluate the Safety and Efficacy of Adalimumab in Subjects With Chronic Plaque Psoriasis and Nail Psoriasis

Start: Jan 2014Est. completion: Apr 2016217 patients
Phase 3Completed

A Study of Adalimumab After Dose Escalation in Japanese Subjects With Crohn's Disease

Start: Sep 2013Est. completion: Oct 201528 patients
Phase 3Completed

Continuing Versus Withdrawing Adalimumab in Maintaining Remission in Non-Radiographic Axial Spondyloarthritis

Start: Apr 2013Est. completion: Apr 2017673 patients
Phase 3Completed

Adalimumab in the Treatment of Chronic Pouchitis

Start: Aug 2012Est. completion: Jan 201613 patients
Phase 3Completed

Extension Study to Assess Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis

Start: Dec 2010Est. completion: Feb 20110
Phase 3Withdrawn

A Study of the Long-term Safety and Efficacy of Adalimumab in Subjects With Intermediate-, Posterior-, or Pan-uveitis

Start: Nov 2010Est. completion: May 2018424 patients
Phase 3Completed

MAP Study: Methotrexate and Adalimumab in Psoriasis

Start: Apr 2017Est. completion: Dec 201856 patients
Phase 2/3Completed

Fluorescence Imaging of IBD and RA Using Adalimumab-800CW

Start: Aug 2024Est. completion: Aug 202636 patients
Phase 2Recruiting
NCT01280669SantenIntravitreal injection 440mcg

Intravitreal Sirolimus as Therapeutic Approach to Uveitis

Start: Sep 2022Est. completion: Dec 2024
Phase 2Withdrawn

A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of ABBV-3373 in Participants With Moderate to Severe Rheumatoid Arthritis (RA)

Start: Mar 2019Est. completion: Aug 202048 patients
Phase 2Completed

A Phase 2 Study to Investigate the Safety, Tolerability and Efficacy of ABT-122 in Subjects With Active Psoriatic Arthritis (PsA) Who Have an Inadequate Response to Methotrexate (MTX)

Start: Apr 2015Est. completion: Jul 2016240 patients
Phase 2Completed

Osteoarthritis of the Knee, Inflammation, and the Effect of Adalimumab (OKINADA)

Start: Mar 2015Est. completion: Mar 202162 patients
Phase 2Completed

Study to Evaluate the Pharmacokinetics, Safety and Efficacy of Two Treatment Modules in Chinese Subjects With Moderate to Severe Crohn's Disease

Start: Dec 2013Est. completion: Feb 201530 patients
Phase 2Completed

Abatacept in the Treatment of Uveitis

Start: Jan 2012Est. completion: Jun 201710 patients
Phase 2Completed

Lucentis for Inflammatory Macular Edema Trial

Start: Jul 2007Est. completion: Dec 20097 patients
Phase 1/2Completed

An Observational Study to Assess Change in Disease Activity and Adverse Events of Adalimumab in Chinese Pediatric Participants With Polyarticular Juvenile Idiopathic Arthritis (pJIA)

Start: Nov 2022Est. completion: Sep 202420 patients
N/ACompleted

Changes in Ultrasonographic Assessment of Inflammation Upon Initiation of Adalimumab Combination Therapy in Chinese Rheumatoid Arthritis (RA) Patients With Inadequate Response to Methotrexate

Start: Sep 2018Est. completion: Nov 20180
N/AWithdrawn

A Study to Assess Persistence, Adherence and Changes in Disease Activity in the Children Population of Juvenile Arthritis Patients Treated With Adalimumab (HUMIRA®)

Start: May 2018Est. completion: Sep 202070 patients
N/ACompleted

Post-marketing Surveillance Study of Adalimumab (Humira®) for Non-infectious Intermediate, Posterior, or Panuveitis Patients

Start: Jan 2018Est. completion: Jul 2020158 patients
N/ACompleted

A Post-Marketing-Observational Study (PMOS) to Determine the Effectiveness of Combined Adalimumab Treatment and Active Supervised Training in Patients With Axial Spondyloarthritis (axSpA)

Start: Dec 2017Est. completion: Sep 201817 patients
N/ATerminated

A Study to Assess Safety and Effectiveness of Adalimumab for Treating Children and Adolescents With Crohn's Disease in Real Life Conditions

Start: Sep 2017Est. completion: Oct 201962 patients
N/ATerminated

A Study to Evaluate the Effectiveness and Patient-Reported Outcome of Adalimumab in Patients With Moderate to Severe Plaque Psoriasis in China

Start: Sep 2017Est. completion: Aug 2020181 patients
N/ACompleted

Real-World Outcome of Psoriasis Subjects in Korea on Adalimumab

Start: Mar 2017Est. completion: Apr 201997 patients
N/ACompleted

TDM Guided Early Optimization of ADAL in Crohn's Disease

Start: Jan 2017Est. completion: Jun 2025200 patients
N/AActive Not Recruiting

A Study to Provide Real-world Evidence on the Treatment Goal Achievement Rate, Adherence to and Utilization Patterns of Adalimumab in Patients With Moderate to Severe Plaque Psoriasis in Greece

Start: Jun 2016Est. completion: Apr 2019273 patients
N/ACompleted

Post-marketing Observational Study to Evaluate the Incremental Impact of AbbVie's Patient Support Program on Patient Reported Outcomes and Health Resource Utilization in Inflammatory Arthritis, Psoriasis and Inflammatory Bowel Diseases in Hungary (VALUE)

Start: Apr 2016Est. completion: Apr 2018427 patients
N/ACompleted

Post Marketing Observational Study (PMOS) to Assess Quality of Life in Swedish Hidradenitis Suppurativa (HS) Patients

Start: Apr 2016Est. completion: Mar 201824 patients
N/ACompleted

A Prospective, Mono-Country and Multi-center Study to Observe Safety and Effectiveness of Adalimumab in KoREan Intestinal Behcet's Disease(BD) Patients

Start: Feb 2016Est. completion: Mar 202059 patients
N/ACompleted

Real-World Outcome of Rheumatoid Arthritis Patients in Korea on Adalimumab

Start: Nov 2015Est. completion: Dec 201791 patients
N/ACompleted

Related Jobs in Ophthalmology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
4 actively recruiting trials targeting 8,158 patients
8 companies competing in this space