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Relapsing Remitting Multiple Sclerosis

Neurology
22
Pipeline Programs
30
Companies
50
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
11
1
1
7
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
556%
Small Molecule
333%
Peptide
111%
+ 51 programs with unclassified modality

Neurology is a $26.9B market dominated by a single blockbuster anticoagulant (ELIQUIS), representing a mature but consolidating therapeutic area.

$26.9B marketMature→ Stable30 products15 companies

Key Trends

  • Extreme market concentration: 68% of spending driven by one FXa inhibitor product
  • Psychiatric and migraine therapies emerging as secondary growth drivers
  • High clinical trial activity (8,279 trials) signals continued pipeline development

Career Verdict

Neurology offers solid career stability with good hiring demand, but limited upside growth—best suited for professionals seeking established market positions rather than emerging-area innovation.

AI-generated market analysis based on FDA, CMS, ClinicalTrials.gov, and hiring data

Market Leaders

#1ELIQUISStable
$18.3B
Bristol Myers Squibb·Launch15.0yr
$1.8B
#3BRILINTAStable
$692M
AstraZeneca·Peak10.2yr
#4NUPLAZIDStable
$596M
$530M
Johnson & Johnson·Peak15.6yr

Drug Class Breakdown

FXa Inhibitors (anticoagulant)
$18.3B(68%)

market-defining single product

Dopamine/Serotonin Antagonists (psychiatric)
$2.4B(9%)

stable mature class

P2Y12 Receptor Antagonists (antiplatelet)
$692M(3%)

niche but stable

5-HT2A Inverse Agonists (psychiatric)
$596M(2%)

specialty indication focus

CGRP Receptor Antagonists (migraine)
$931M(3%)

emerging growth segment

Immunomodulators (MS)
$747M(3%)

stable with LOE risk

Other mechanisms
$2.6B(10%)

diverse small products

Career Outlook

Stable

Neurology represents a mature, cash-generative market with limited growth tailwinds but strong hiring stability. The dominance of ELIQUIS creates a bifurcated career landscape: high-opportunity positions in emerging segments (CGRP antagonists, psychiatric therapeutics) and commoditized roles in anticoagulant franchises. Job availability is solid but growth expectations should be tempered relative to oncology or immunology.

Breaking In

Entry-level professionals should target clinical operations or commercial support roles at J&J, AstraZeneca, or Sanofi to build domain expertise in neurology disease states and competitive dynamics.

For Experienced Professionals

Experienced professionals should prioritize emerging mechanism roles (CGRP, tau-targeting programs) or pivot to medtech/neurotech (Stryker, Medtronic) to capture higher growth and salary potential than traditional pharma incumbents.

In-Demand Skills

Medical Science Liaisons (MSL) for specialist engagementClinical trial operations expertisePsychiatric/neurodegenerative disease educationRegulatory affairs (given patent cliff activity)Commercial strategy around branded/generic transitions

Best For

Medical Science LiaisonCommercial Brand Manager (anticoagulant/psychiatric franchises)Clinical Operations ManagerRegulatory Affairs SpecialistClinical Development Manager (CGRP/immunomodulator pipelines)

Hiring Landscape

$100K-$199K

Neurology shows moderate but distributed hiring across pharma and medtech employers, with 4,186 total jobs listed. Commercial functions lead (947 roles, $169K avg), followed by clinical operations (467 roles, $132K avg), indicating bias toward commercialization over R&D. Takeda leads external hiring (762 jobs) with strong representation in contract research and CRO spaces.

4,186
Open Roles
5
Companies Hiring
5
Departments

Top Hiring Companies

762Growing
434Stable
302Stable

By Department

Commercial(23%)
$169K
Clinical Operations(11%)
$132K
Engineering(8%)
$199K
IT(4%)
$100K
Manufacturing(3%)
$170K

Commercial and clinical operations roles dominate, offering stable mid-career positions; engineering roles command premium salaries ($199K), suggesting strong device/neurotech hiring pockets.

Competitive Landscape

29 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
11 programs
1
7
FingolimodPhase 41 trial
FingolimodPhase 41 trial
FingolimodPhase 41 trial
FingolimodPhase 41 trial
FingolimodPhase 41 trial
+6 more programs
Active Trials
NCT02277964Completed25Est. Aug 2016
NCT05171972Active Not Recruiting40Est. Jun 2025
NCT02335892Completed114Est. Feb 2017
+8 more trials
Alkermes
AlkermesDUBLIN 4, Ireland
1 program
1
ALKS 8700Phase 3
Prevail Therapeutics
1 program
1
dirucotidePhase 2/3Peptide1 trial
Active Trials
NCT00869986Completed218Est. Sep 2009
Eppendorf
EppendorfGermany - Hamburg
1 program
1
Boswellic acidsPhase 21 trial
Active Trials
NCT01450124Completed29Est. Dec 2014
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
1 program
1
EstriolPhase 21 trial
Active Trials
NCT00451204Completed158Est. Jul 2014
Utah Medical
Utah MedicalIreland - Dublin
1 program
1
EstriolPhase 2
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
EstriolPhase 2
Bayer
BayerLEVERKUSEN, Germany
1 program
1
FlupirtinePhase 21 trial
Active Trials
NCT00623415Terminated30Est. Nov 2012
Cell Technologies
1
NT-KO-003Phase 2
Boston Scientific
Boston ScientificCA - Valencia
1 program
1
Pleneva TM BGC20-0134Phase 21 trial
Active Trials
NCT01037907Terminated173Est. Dec 2011
RedHill Biopharma
RedHill BiopharmaIsrael - Tel Aviv
1 program
1
RHB-104Phase 21 trial
Active Trials
NCT01717664Completed18Est. Jul 2016
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
RaltegravirPhase 2Small Molecule
MSD
MSDIreland - Ballydine
1 program
1
RaltegravirPhase 2Small Molecule1 trial
Active Trials
NCT01767701Completed23Est. Sep 2014
Anokion
AnokionSwitzerland - Ecublens
1 program
1
ANK-700Phase 11 trial
Active Trials
NCT04602390Completed34Est. Apr 2024
Stragen Pharma
Stragen PharmaSwitzerland - Plan-les-Ouates
1 program
1
olesoximePhase 1
Biogen
BiogenCAMBRIDGE, MA
11 programs
Adaptive Optics OphthalmoscopyN/A1 trial
Clinical assessmentN/A1 trial
NatalizumabN/AMonoclonal Antibody1 trial
BG00012PHASE_11 trial
natalizumabPHASE_2Monoclonal Antibody1 trial
+6 more programs
Active Trials
NCT04289909Completed50Est. Jul 2024
NCT05446285Unknown245Est. Aug 2023
NCT04832399Completed60Est. Oct 2023
+8 more trials
Teva
TevaIsrael - Petach Tikva
7 programs
tDCSN/A1 trial
LaquinimodPHASE_21 trial
laquinimod 0.3PHASE_21 trial
Glatiramer AcetatePHASE_31 trial
Glatiramer acetatePHASE_31 trial
+2 more programs
Active Trials
NCT02266121Terminated100Est. May 2023
NCT00745615Terminated257Est. Jul 2017
NCT00349193Completed306Est. Aug 2006
+4 more trials
Novartis
NovartisBASEL, Switzerland
4 programs
Disease Control in RRMS Transferring Treatment From Natalizumab to FingolimodN/A
BAF312PHASE_2
FingolimodPHASE_4
Fingolimod 0.5 mgPHASE_4
Providence Therapeutics
2 programs
Evaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to OcrelizumabN/AMonoclonal Antibody
3 mg MelatoninPHASE_11 trial
Active Trials
NCT03498131Completed30Est. Dec 2023
Roche
RocheSTAVANGER NORWAY, Norway
2 programs
MS Care PlatformN/A
olesoximePHASE_1
Hikma
HikmaNJ - Berkeley Heights
1 program
Dimethyl FumarateN/A1 trial
Active Trials
NCT04468165Completed160Est. Jul 2023
Genentech
GenentechCA - Oceanside
1 program
MS Care PlatformN/A1 trial
Active Trials
NCT05949580Recruiting500Est. Mar 2028
icometrix
icometrixBelgium - Leuven
1 program
MS Care PlatformN/A
Clene
CleneSALT LAKE CITY, UT
1 program
CNM-Au8PHASE_21 trial
Active Trials
NCT03536559Terminated73Est. Jul 2022
AdvanCell
AdvanCellAustralia - Pullenvale
1 program
NT-KO-003PHASE_21 trial
Active Trials
NCT01428726Completed99Est. Jan 2014
Contineum Therapeutics
1 program
PIPE-307 Dose APHASE_21 trial
Active Trials
NCT06083753Completed182Est. Aug 2025
Revalesio
RevalesioWA - Tacoma
1 program
RNS60 125 mlPHASE_21 trial
Active Trials
NCT01714089Withdrawn0
TG Therapeutics
TG TherapeuticsNEW YORK, NY
1 program
UblituximabPHASE_2Monoclonal Antibody1 trial
Active Trials
NCT03381170Completed48Est. Nov 2022
Merck & Co.
Merck & Co.RAHWAY, NJ
1 program
Rebif®PHASE_45 trials
Active Trials
NCT02254304Completed106Est. Aug 2016
NCT02064816Completed200Est. Apr 2016
NCT01791244Completed93Est. Feb 2016
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Biogenpeginterferon beta-1a
SandozFingolimod 0.5 mg
Merck & Co.Rebif®
BiogenSimethicone
Merck & Co.Rebif®
SandozFingolimod
Merck & Co.Rebif®
SandozFingolimod
SandozFingolimod
SandozFingolimod
SandozFingolimod
SandozFingolimod
TevaGlatiramer Acetate
Merck & Co.Rebif®
BiogenInterferon beta-1a

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 11,032 patients across 50 trials

NCT03177083Biogenpeginterferon beta-1a

Evaluate Safety/Tolerability in Portuguese Participants With RRMS Transitioning From Current Therapy

Start: Jan 2017Est. completion: Oct 202080 patients
Phase 4Completed
NCT02373098SandozFingolimod 0.5 mg

Fingolimod Effect on Cytokine and Chemokine Levels

Start: Mar 2015Est. completion: Jan 2017126 patients
Phase 4Completed

Effectiveness of Rebif® in Clinically Isolated Syndrome and Relapsing Multiple Sclerosis Using RebiSmart™

Start: Dec 2014Est. completion: Aug 2016106 patients
Phase 4Completed

Pilot Study to Assess Dimethyl Fumarate Related GI Symptom Mitigation

Start: Jul 2014Est. completion: Jun 20155 patients
Phase 4Terminated

A Study of Rebif® in Subjects With Relapsing Multiple Sclerosis

Start: May 2014Est. completion: Apr 2016200 patients
Phase 4Completed

Study to Assess Immune Function and MRI Disease Activity in RRMS Patients When Switching From Natalizumab to Gilenya

Start: Mar 2014Est. completion: Apr 201615 patients
Phase 4Unknown

A Phase 4 Study to Assess the Impact of Patient Support Program on Health Related Quality of Life and Adherence in Subjects With Relapsing-Remitting Multiple Sclerosis Administered Rebif® With the RebiSmart™ Device

Start: Feb 2013Est. completion: Feb 201693 patients
Phase 4Completed

Long-term Effect of Fingolimod on Circulating Immunocompetent Mononuclear Cells in Patients With Multiple Sclerosis

Start: Jan 2013Est. completion: Feb 20168 patients
Phase 4Terminated

Evaluation of Patient Retention of Fingolimod vs. Currently Approved Disease Modifying Therapy in Patients With Relapsing Remitting Multiple Sclerosis.

Start: Jun 2012Est. completion: Jul 2015881 patients
Phase 4Completed

Evaluation of Patient Reported Outcomes in RRMS Patients Candidates for MS Therapy Change and Transitioned to Fingolimod 0.5 mg (EPOC)

Start: Jan 2012Est. completion: Jun 2013298 patients
Phase 4Completed

Efficacy of Fingolimod in de Novo Patients Versus Fingolimod in Patients Previously Treated With a First Line Disease Modifying Therapy

Start: Dec 2011Est. completion: Dec 2015347 patients
Phase 4Completed

Patients With Relapse Remitting Multiple Sclerosis (RRMS): Candidates for MS Therapy Change

Start: May 2011Est. completion: Jun 201461 patients
Phase 4Completed
NCT00202995TevaGlatiramer Acetate

Randomized Study Designed to Look at Disease Progression Using 2 Currently FDA Approved Drugs for the Treatment of RRMS

Start: Jul 2004Est. completion: Oct 200791 patients
Phase 4Terminated

Study To Evaluate The Immunogenicity And Safety Of r-hIFN Beta-1a (Rebif®) Using Clone 484-39 In Multiple Sclerosis

Start: May 2004Est. completion: Jan 2006460 patients
Phase 4Completed
NCT00534261BiogenInterferon beta-1a

Does Quality of Life Improve in Multiple Sclerosis Patients Treated With Interferon Beta-1a?

Start: Nov 1999Est. completion: Feb 2004284 patients
Phase 4Completed

A Tolerability Study of ALKS 8700 in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS) EVOLVE-MS-2

Start: Mar 2017Est. completion: Jun 2019506 patients
Phase 3Completed
NCT01975298TevaLaquinimod

A Study to Evaluate 2 Doses Of Oral Administration Of Laquinimod Compared to Interferon ß-1a Administered by Injection in Participants With Relapsing Remitting Multiple Sclerosis (RRMS)

Start: Jan 2014Est. completion: Mar 20140
Phase 3Withdrawn

Using Optical Coherence Tomography (OCT) to Evaluate the Efficacy and Safety of PEGylated Interferon Beta-1a (BIIB017) in Patients With Relapsing Multiple Sclerosis

Start: Aug 2010Est. completion: Aug 20130
Phase 3Withdrawn
NCT01067521TevaGlatiramer acetate

A Study in Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS) to Assess the Efficacy, Safety and Tolerability of Glatiramer Acetate (GA) Injection 40 mg Administered Three Times a Week Compared to Placebo

Start: Jun 2010Est. completion: May 20171,404 patients
Phase 3Completed
NCT00947752TevaGlatiramer Acetate

Safety of New Formulation of Glatiramer Acetate

Start: Jul 2009Est. completion: Nov 2009147 patients
Phase 3Completed

A Safety Study of Combination Treatment With Avonex and Zocor in Relapsing Remitting Multiple Sclerosis

Start: Oct 200530 patients
Phase 3Unknown

A Prospective Study Looking at the Use of Rebif® in Subjects With Clinically Isolated Syndrome

Start: Oct 2005Est. completion: Nov 200835 patients
Phase 3Completed

Tolerability of Rebif® Injection With and Without the Use of Rebiject™Mini in Relapsing-Remitting Multiple Sclerosis Subjects

Start: Jan 2001Est. completion: Dec 20021,883 patients
Phase 3Completed

A Study of Rebif® Compared With Avonex® in the Treatment of Relapsing-remitting Multiple Sclerosis (MS)

Start: Nov 1999Est. completion: Jun 2002677 patients
Phase 3Completed

A Study for Patients With Relapsing Remitting Multiple Sclerosis

Start: Nov 2006Est. completion: Sep 2009218 patients
Phase 2/3Completed

Proof of Concept Study Evaluating RNS60 in the Treatment of Relapsing Remitting Multiple Sclerosis

0
Phase 2Withdrawn

Study to Evaluate the Safety and Efficacy of PIPE-307 in Subjects With Relapsing-Remitting Multiple Sclerosis

Start: Nov 2023Est. completion: Aug 2025182 patients
Phase 2Completed

Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis

Start: Nov 2018Est. completion: Jul 202273 patients
Phase 2Terminated

An Extension of the TG1101-RMS201 Trial

Start: Jun 2017Est. completion: Nov 202248 patients
Phase 2Completed

Proof of Concept Study of RHB-104 as Add-On Therapy to Interferon Beta-1a in Relapsing Remitting Multiple Sclerosis (RRMS)

Start: Jun 2013Est. completion: Jul 201618 patients
Phase 2Completed
NCT01767701MSDRaltegravir

Raltegravir (Isentress) Pilot Study in Relapsing Multiple Sclerosis

Start: Apr 2013Est. completion: Sep 201423 patients
Phase 2Completed
NCT01450124EppendorfBoswellic acids

Safety, Tolerability And Mechanism Of Action Of Boswellic Acids (BA) In Multiple Sclerosis (SABA)

Start: Sep 2011Est. completion: Dec 201429 patients
Phase 2Completed

A Phase IIa Study of NT-KO-003 for Multiple Sclerosis

Start: Jun 2011Est. completion: Jan 201499 patients
Phase 2Completed

Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis

Start: Aug 2010Est. completion: Oct 2016185 patients
Phase 2Completed

Treatment Interruption of Natalizumab

Start: Mar 2010Est. completion: Nov 2011175 patients
Phase 2Completed
NCT01037907Boston ScientificPleneva TM BGC20-0134

A Study of Orally Administered BGC20-0134 (Structured Lipid) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)

Start: Nov 2009Est. completion: Dec 2011173 patients
Phase 2Terminated

Flupirtine as Oral Treatment in Multiple Sclerosis

Start: Dec 2007Est. completion: Nov 201230 patients
Phase 2Terminated

A Combination Trial of Copaxone Plus Estriol in Relapsing Remitting Multiple Sclerosis (RRMS)

Start: Mar 2007Est. completion: Jul 2014158 patients
Phase 2Completed
NCT00745615TevaLaquinimod

An Extension Study of LAQ/5062 Exploring the Long Term Safety, Tolerability and Clinical Effect Parameters During the Disease

Start: Dec 2005Est. completion: Jul 2017257 patients
Phase 2Terminated
NCT00349193Tevalaquinimod 0.3

A Study to Evaluate the Effectiveness, Tolerability and Safety of Laquinimod

Start: Mar 2005Est. completion: Aug 2006306 patients
Phase 2Completed

Assessment of ANK-700 in Patients With Relapsing Remitting Multiple Sclerosis

Start: Nov 2020Est. completion: Apr 202434 patients
Phase 1Completed

Melatonin in Patients With Multiple Sclerosis (MS).

Start: May 2018Est. completion: Dec 202330 patients
Phase 1Completed

A 24-Hour Pharmacokinetic Determination of BG00012 After Single-Day Oral Administration in Subjects With MS

Start: Feb 2009Est. completion: Oct 200948 patients
Phase 1Completed
NCT05949580GenentechMS Care Platform

Study to Evaluate the Usability and Value of Integrated Digital Solutions in Medical Care of Participants With Multiple Sclerosis

Start: Oct 2024Est. completion: Mar 2028500 patients
N/ARecruiting
NCT05446285BiogenClinical assessment

Multiple Sclerosis Outcome Determination Evaluating Real Differences After TimE

Start: Feb 2022Est. completion: Aug 2023245 patients
N/AUnknown

Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment

Start: Jan 2022Est. completion: Jun 202540 patients
N/AActive Not Recruiting
NCT04468165HikmaDimethyl Fumarate

Effectiveness and Safety of Generic Delayed-Release Dimethyl Fumarate (Sclera® or Marovarex ®, Hikma) in Routine Medical Practice in the Treatment of Relapsing-Remitting Multiple Sclerosis in MENA Region

Start: Feb 2021Est. completion: Jul 2023160 patients
N/ACompleted
NCT04289909BiogenAdaptive Optics Ophthalmoscopy

Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS)

Start: Dec 2020Est. completion: Jul 202450 patients
N/ACompleted
NCT02335892SandozPROFILE - Evaluation of QoL and PRO Outcomes in Patients Taking Fingolimod

PROFILE - Evaluation of QoL and PRO Outcomes in Patients Taking Fingolimod

Start: Nov 2014Est. completion: Feb 2017114 patients
N/ACompleted

Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis

Start: Oct 2014Est. completion: May 2023100 patients
N/ATerminated

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 11,032 patients
30 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.