Relapsing Remitting Multiple Sclerosis

Neurology
34
Pipeline Programs
14
Companies
50
Clinical Trials
1 recruiting
8
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
9
0
7
15
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
480%
Small Molecule
120%
+ 28 programs with unclassified modality

On Market (8)

Approved therapies currently available

Biogen
AVONEXApproved
interferon beta-1a
Biogen
Interferon beta [EPC]intramuscular1996
Teva
COPAXONEApproved
glatiramer acetate
Teva
subcutaneous1996
U
FINGOLIMODApproved
fingolimod
Unknown Company
oral
U
FLOLIPIDApproved
simvastatin
Unknown Company
oral2016
U
GLATIRAMER ACETATEApproved
glatiramer acetate
Unknown Company
subcutaneous2024
Biogen
PLEGRIDYApproved
peginterferon beta-1a
Biogen
Interferon beta [EPC]injection2014
U
REBIFApproved
interferon beta-1a
Unknown Company
Interferon beta [EPC]subcutaneous2002
U
SIMVASTATINApproved
simvastatin
Unknown Company
oral2006

Competitive Landscape

12 companies ranked by most advanced pipeline stage

Biogen
BiogenCAMBRIDGE, MA
11 programs
1
1
3
3
Interferon beta-1aPhase 41 trial
SimethiconePhase 41 trial
peginterferon beta-1aPhase 41 trial
ALKS 8700Phase 31 trial
BIIB017Phase 31 trial
+6 more programs
Active Trials
NCT04289909Completed50Est. Jul 2024
NCT05446285Unknown245Est. Aug 2023
NCT04832399Completed60Est. Oct 2023
+8 more trials
Teva
TevaIsrael - Petach Tikva
7 programs
2
3
1
Glatiramer AcetatePhase 41 trial
Glatiramer AcetatePhase 31 trial
Glatiramer acetatePhase 31 trial
LaquinimodPhase 31 trial
LaquinimodPhase 23 trials
+2 more programs
Active Trials
NCT02266121Terminated100Est. May 2023
NCT02284568Completed374Est. Oct 2017
NCT02085863Completed40Est. Nov 2014
+6 more trials
Novartis
NovartisBASEL, Switzerland
4 programs
1
2
FingolimodPhase 41 trial
Fingolimod 0.5 mgPhase 45 trials
BAF312Phase 21 trial
Disease Control in RRMS Transferring Treatment From Natalizumab to FingolimodN/A1 trial
Active Trials
NCT02277964Completed25Est. Aug 2016
NCT01185821Completed185Est. Oct 2016
NCT01623596Completed881Est. Jul 2015
+5 more trials
M&
Merck & Co.RAHWAY, NJ
1 program
1
Rebif®Phase 45 trials
Active Trials
NCT02254304CompletedEst. Aug 2016
NCT02064816Completed200Est. Apr 2016
NCT01791244CompletedEst. Feb 2016
+2 more trials
Alkermes
AlkermesDUBLIN 4, Ireland
1 program
1
ALKS 8700Phase 3
Clene
CleneSALT LAKE CITY, UT
1 program
1
CNM-Au8Phase 21 trial
Active Trials
NCT03536559TerminatedEst. Jul 2022
AdvanCell
AdvanCellAustralia - Pullenvale
1 program
1
NT-KO-003Phase 21 trial
Active Trials
NCT01428726CompletedEst. Jan 2014
Contineum Therapeutics
1 program
1
PIPE-307 Dose APhase 21 trial
Active Trials
NCT06083753Completed182Est. Aug 2025
Revalesio
RevalesioWA - Tacoma
1 program
1
RNS60 125 mlPhase 21 trial
Active Trials
NCT01714089Withdrawn
TG Therapeutics
TG TherapeuticsNEW YORK, NY
1 program
1
UblituximabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT03381170Completed48Est. Nov 2022
Providence Therapeutics
2 programs
1
3 mg MelatoninPhase 11 trial
Evaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to OcrelizumabN/AMonoclonal Antibody1 trial
Active Trials
NCT03157830Completed43Est. Jun 2022
NCT03498131CompletedEst. Dec 2023
Roche
RocheSTAVANGER NORWAY, Norway
2 programs
1
olesoximePhase 11 trial
MS Care PlatformN/A1 trial
Active Trials
NCT05949580Recruiting500Est. Mar 2028
NCT01808885Completed44Est. Jan 2014

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Biogenpeginterferon beta-1a
NovartisFingolimod 0.5 mg
Merck & Co.Rebif®
BiogenSimethicone
Merck & Co.Rebif®
Merck & Co.Rebif®
NovartisFingolimod
NovartisFingolimod 0.5 mg
TevaGlatiramer Acetate
Merck & Co.Rebif®
BiogenInterferon beta-1a
BiogenALKS 8700
TevaLaquinimod
NovartisFingolimod 0.5 mg
BiogenBIIB017

Showing 15 of 49 trials with date data

Clinical Trials (50)

Total enrollment: 12,806 patients across 50 trials

NCT03177083Biogenpeginterferon beta-1a

Evaluate Safety/Tolerability in Portuguese Participants With RRMS Transitioning From Current Therapy

Start: Jan 2017Est. completion: Oct 202080 patients
Phase 4Completed
NCT02373098NovartisFingolimod 0.5 mg

Fingolimod Effect on Cytokine and Chemokine Levels

Start: Mar 2015Est. completion: Jan 2017126 patients
Phase 4Completed

Effectiveness of Rebif® in Clinically Isolated Syndrome and Relapsing Multiple Sclerosis Using RebiSmart™

Start: Dec 2014Est. completion: Aug 2016
Phase 4Completed

Pilot Study to Assess Dimethyl Fumarate Related GI Symptom Mitigation

Start: Jul 2014Est. completion: Jun 20155 patients
Phase 4Terminated

A Study of Rebif® in Subjects With Relapsing Multiple Sclerosis

Start: May 2014Est. completion: Apr 2016200 patients
Phase 4Completed

A Phase 4 Study to Assess the Impact of Patient Support Program on Health Related Quality of Life and Adherence in Subjects With Relapsing-Remitting Multiple Sclerosis Administered Rebif® With the RebiSmart™ Device

Start: Feb 2013Est. completion: Feb 2016
Phase 4Completed

Evaluation of Patient Retention of Fingolimod vs. Currently Approved Disease Modifying Therapy in Patients With Relapsing Remitting Multiple Sclerosis.

Start: Jun 2012Est. completion: Jul 2015881 patients
Phase 4Completed
NCT01534182NovartisFingolimod 0.5 mg

Evaluation of Patient Reported Outcomes in RRMS Patients Candidates for MS Therapy Change and Transitioned to Fingolimod 0.5 mg (EPOC)

Start: Jan 2012Est. completion: Jun 2013298 patients
Phase 4Completed
NCT00202995TevaGlatiramer Acetate

Randomized Study Designed to Look at Disease Progression Using 2 Currently FDA Approved Drugs for the Treatment of RRMS

Start: Jul 2004Est. completion: Oct 200791 patients
Phase 4Terminated

Study To Evaluate The Immunogenicity And Safety Of r-hIFN Beta-1a (Rebif®) Using Clone 484-39 In Multiple Sclerosis

Start: May 2004Est. completion: Jan 2006460 patients
Phase 4Completed
NCT00534261BiogenInterferon beta-1a

Does Quality of Life Improve in Multiple Sclerosis Patients Treated With Interferon Beta-1a?

Start: Nov 1999Est. completion: Feb 2004284 patients
Phase 4Completed

A Tolerability Study of ALKS 8700 in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS) EVOLVE-MS-2

Start: Mar 2017Est. completion: Jun 2019506 patients
Phase 3Completed
NCT01975298TevaLaquinimod

A Study to Evaluate 2 Doses Of Oral Administration Of Laquinimod Compared to Interferon ß-1a Administered by Injection in Participants With Relapsing Remitting Multiple Sclerosis (RRMS)

Start: Jan 2014Est. completion: Mar 20140
Phase 3Withdrawn
NCT01625182NovartisFingolimod 0.5 mg

Evaluate Efficacy and Safety of Fingolimod 0.5 mg Orally Once Daily Versus Placebo in Chronic Inflammatory Demyelinating Polyradiculoneuropathy Patients.

Start: Dec 2012Est. completion: Sep 2016106 patients
Phase 3Completed

Using Optical Coherence Tomography (OCT) to Evaluate the Efficacy and Safety of PEGylated Interferon Beta-1a (BIIB017) in Patients With Relapsing Multiple Sclerosis

Start: Aug 2010Est. completion: Aug 20130
Phase 3Withdrawn
NCT01067521TevaGlatiramer acetate

A Study in Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS) to Assess the Efficacy, Safety and Tolerability of Glatiramer Acetate (GA) Injection 40 mg Administered Three Times a Week Compared to Placebo

Start: Jun 2010Est. completion: May 20171,404 patients
Phase 3Completed
NCT00947752TevaGlatiramer Acetate

Safety of New Formulation of Glatiramer Acetate

Start: Jul 2009Est. completion: Nov 2009147 patients
Phase 3Completed
NCT00662649NovartisFingolimod 0.5 mg

Long-term Efficacy and Safety of Fingolimod (FTY720) in Patients With Relapsing-remitting Multiple Sclerosis

Start: Feb 2008Est. completion: Jun 2011920 patients
Phase 3Completed
NCT00340834NovartisFingolimod 0.5 mg

Efficacy and Safety of Fingolimod in Patients With Relapsing-remitting Multiple Sclerosis With Optional Extension Phase

Start: May 2006Est. completion: Jul 20111,292 patients
Phase 3Completed
NCT00289978NovartisFingolimod 0.5 mg

Efficacy and Safety of Fingolimod in Patients With Relapsing-remitting Multiple Sclerosis

Start: Jan 2006Est. completion: Jul 20091,272 patients
Phase 3Completed

A Prospective Study Looking at the Use of Rebif® in Subjects With Clinically Isolated Syndrome

Start: Oct 2005Est. completion: Nov 2008
Phase 3Completed

A Safety Study of Combination Treatment With Avonex and Zocor in Relapsing Remitting Multiple Sclerosis

Start: Oct 200530 patients
Phase 3Unknown

Tolerability of Rebif® Injection With and Without the Use of Rebiject™Mini in Relapsing-Remitting Multiple Sclerosis Subjects

Start: Jan 2001Est. completion: Dec 2002
Phase 3Completed

A Study of Rebif® Compared With Avonex® in the Treatment of Relapsing-remitting Multiple Sclerosis (MS)

Start: Nov 1999Est. completion: Jun 2002677 patients
Phase 3Completed

Proof of Concept Study Evaluating RNS60 in the Treatment of Relapsing Remitting Multiple Sclerosis

Phase 2Withdrawn

Study to Evaluate the Safety and Efficacy of PIPE-307 in Subjects With Relapsing-Remitting Multiple Sclerosis

Start: Nov 2023Est. completion: Aug 2025182 patients
Phase 2Completed

Nanocrystalline Gold to Treat Remyelination Failure in Chronic Optic Neuropathy In Multiple Sclerosis

Start: Nov 2018Est. completion: Jul 2022
Phase 2Terminated

An Extension of the TG1101-RMS201 Trial

Start: Jun 2017Est. completion: Nov 202248 patients
Phase 2Completed
NCT02284568TevaLaquinimod

A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple Sclerosis to Assess the Efficacy, Safety and Tolerability of Two Oral Doses of Laquinimod Either of 0.6 mg/Day or 1.5mg/Day (Experimental Drug) as Compared to Placebo

Start: Jan 2015Est. completion: Oct 2017374 patients
Phase 2Completed

A Phase IIa Study of NT-KO-003 for Multiple Sclerosis

Start: Jun 2011Est. completion: Jan 2014
Phase 2Completed

Long-term Safety, Tolerability and Efficacy of BAF312 Given Orally in Patients With Relapsing-remitting Multiple Sclerosis

Start: Aug 2010Est. completion: Oct 2016185 patients
Phase 2Completed

Treatment Interruption of Natalizumab

Start: Mar 2010Est. completion: Nov 2011175 patients
Phase 2Completed
NCT00745615TevaLaquinimod

An Extension Study of LAQ/5062 Exploring the Long Term Safety, Tolerability and Clinical Effect Parameters During the Disease

Start: Dec 2005Est. completion: Jul 2017257 patients
Phase 2Terminated
NCT00349193Tevalaquinimod 0.3

A Study to Evaluate the Effectiveness, Tolerability and Safety of Laquinimod

Start: Mar 2005Est. completion: Aug 2006306 patients
Phase 2Completed

Melatonin in Patients With Multiple Sclerosis (MS).

Start: May 2018Est. completion: Dec 2023
Phase 1Completed
NCT02085863TevaLaquinimod

A Phase I Study in Young Healthy Women to Investigate the Effects of Laquinimod on Standard Oral Contraceptive When Both Treatments Are Given Together

Start: Feb 2014Est. completion: Nov 201440 patients
Phase 1Completed

Safety Study of Olesoxime in Patients With Stable Relapsing Remitting Multiple Sclerosis Treated With Interferon Beta.

Start: Apr 2013Est. completion: Jan 201444 patients
Phase 1Completed

A 24-Hour Pharmacokinetic Determination of BG00012 After Single-Day Oral Administration in Subjects With MS

Start: Feb 2009Est. completion: Oct 200948 patients
Phase 1Completed
NCT05949580RocheMS Care Platform

Study to Evaluate the Usability and Value of Integrated Digital Solutions in Medical Care of Participants With Multiple Sclerosis

Start: Oct 2024Est. completion: Mar 2028500 patients
N/ARecruiting
NCT05446285BiogenClinical assessment

Multiple Sclerosis Outcome Determination Evaluating Real Differences After TimE

Start: Feb 2022Est. completion: Aug 2023245 patients
N/AUnknown
NCT04289909BiogenAdaptive Optics Ophthalmoscopy

Identification of Retinal Perivascular Inflammation in Patients With Multiple Sclerosis Using Adaptive Optics (RETIMUS)

Start: Dec 2020Est. completion: Jul 202450 patients
N/ACompleted
NCT03157830Providence TherapeuticsEvaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to Ocrelizumab

Evaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to Ocrelizumab

Start: Jun 2017Est. completion: Jun 202243 patients
N/ACompleted

Improving Cognitive Aptitudes With tDCS in Patients With Multiple Sclerosis

Start: Oct 2014Est. completion: May 2023100 patients
N/ATerminated

Study of Tysabri in Early Relapsing Remitting Multiple Sclerosis Participants

Start: Nov 2013Est. completion: Oct 202360 patients
N/ACompleted

An Observational, Retrospective, UK & Ireland Audit of Patient Adherence to Rebif® Injections Using the RebiSmart™ Injection Device

Start: Apr 2012
N/ACompleted
NCT02277964NovartisDisease Control in RRMS Transferring Treatment From Natalizumab to Fingolimod

Disease Control in RRMS Transferring Treatment From Natalizumab to Fingolimod

Start: Mar 2012Est. completion: Aug 201625 patients
N/ACompleted

Post Marketing Surveillance Study to Evaluate the Tolerability of Rebif® New Formulation in Patients With Relapsing Multiple Sclerosis in an Australian Clinical Setting.

Start: Jan 2010Est. completion: Apr 2013
N/ACompleted

An Observational Study for the Assessment of Compliance and Persistence to Rebif® Therapy of Patients With Relapsing-remitting Multiple Sclerosis (MS) and Evaluation of Potential Factors Influencing These Parameters

Start: Dec 2009Est. completion: Sep 2012133 patients
N/ACompleted

An Observational Study for the Assessment of Adherence, Effectiveness and Convenience of Rebif® Treatment in Relapsing Multiple Sclerosis Patients Using RebiSmart™.

Start: Sep 2009Est. completion: Jan 2013912 patients
N/ACompleted

Post-Authorization Observational Study to Evaluate Cognition and Fatigue in Relapsing-remitting Multiple Sclerosis (RRMS) Patients Treated With Rebif®

Start: May 2009Est. completion: Jun 2013300 patients
N/ACompleted

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

7 late-stage (Phase 3) programs — potential near-term approvals
1 actively recruiting trials targeting 12,806 patients
14 companies competing in this space