Primary Myelofibrosis

Hematology
15
Pipeline Programs
8
Companies
14
Clinical Trials
4 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
4
4
0
4
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
9100%
+ 5 programs with unclassified modality

On Market (2)

Approved therapies currently available

PharmaEssentia
BESREMIApproved
ropeginterferon alfa-2b
PharmaEssentia
Interferon alfa-2b [EPC]subcutaneous2021
GSK
OJJAARAApproved
momelotinib
GSK
oral2023

Competitive Landscape

8 companies ranked by most advanced pipeline stage

GSK
GSKLONDON, United Kingdom
6 programs
2
2
2
1
MomelotinibPhase 3Small Molecule1 trial
MomelotinibPhase 3Small Molecule1 trial
MomelotinibPhase 2Small Molecule1 trial
MomelotinibPhase 2Small Molecule1 trial
CYT387Phase 1/21 trial
+1 more programs
Active Trials
NCT00935987Completed166Est. Apr 2012
NCT01423058Completed61Est. Jun 2014
NCT02124746Completed87Est. Dec 2018
+3 more trials
PharmaEssentia
PharmaEssentiaMA - Burlington
1 program
1
1
Ropeginterferon alfa-2bPhase 31 trial
Active Trials
NCT06468033RecruitingEst. Sep 2028
Swedish Orphan Biovitrum
1 program
1
PacritinibPhase 3Small Molecule1 trial
Active Trials
NCT03165734RecruitingEst. Jul 2027
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
RO7490677Phase 21 trial
Active Trials
NCT01981850Completed125Est. Jul 2020
Karyopharm Therapeutics
1 program
1
SelinexorPhase 21 trial
Active Trials
NCT03627403TerminatedEst. Mar 2025
Bristol Myers Squibb
2 programs
1
FedratinibPhase 1/2Small Molecule1 trial
FedratinibN/ASmall Molecule1 trial
Active Trials
NCT06073847Recruiting137Est. Dec 2027
NCT04446650Active Not Recruiting31Est. Nov 2026
AB
Active BiotechSweden - Lund
1 program
1
RuxolitinibPhase 1/2Small Molecule1 trial
Active Trials
NCT06327100RecruitingEst. May 2031
City Therapeutics
City TherapeuticsMA - Cambridge
1 program
1
Allogeneic Hematopoietic Stem Cell TransplantationPhase 11 trial
Active Trials
NCT02917096CompletedEst. Aug 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
PharmaEssentiaRopeginterferon alfa-2b
GSKMomelotinib
Swedish Orphan BiovitrumPacritinib
GSKMomelotinib
Karyopharm TherapeuticsSelinexor
GSKMomelotinib
RocheRO7490677
GSKMomelotinib
Active BiotechRuxolitinib
Bristol Myers SquibbFedratinib
GSKMomelotinib
GSKCYT387
City TherapeuticsAllogeneic Hematopoietic Stem Cell Transplantation
Bristol Myers SquibbFedratinib

Clinical Trials (14)

Total enrollment: 1,354 patients across 14 trials

NCT06468033PharmaEssentiaRopeginterferon alfa-2b

P1101 in Treating Patients With Early PMF or Overt PMF at Low or Intermediate-1 Risk

Start: Jul 2025Est. completion: Sep 2028
Phase 3Recruiting
NCT04173494GSKMomelotinib

A Study of Momelotinib Versus Danazol in Symptomatic and Anemic Myelofibrosis Participants (MOMENTUM)

Start: Feb 2020Est. completion: Dec 2022195 patients
Phase 3Completed

A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis

Start: Jun 2017Est. completion: Jul 2027
Phase 3Recruiting
NCT01969838GSKMomelotinib

Momelotinib Versus Ruxolitinib in Subjects With Myelofibrosis

Start: Dec 2013Est. completion: May 2019432 patients
Phase 3Completed

Selinexor in Myelofibrosis Refractory or Intolerant to JAK1/2 Inhibitors

Start: May 2019Est. completion: Mar 2025
Phase 2Terminated
NCT02124746GSKMomelotinib

Long-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera or Essential Thrombocythemia

Start: Apr 2014Est. completion: Dec 201887 patients
Phase 2Completed

A Phase 2 Study of RO7490677 In Participants With Myelofibrosis

Start: Oct 2013Est. completion: Jul 2020125 patients
Phase 2Completed
NCT01236638GSKMomelotinib

Extension Study Evaluating the Long Term Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)

Start: Nov 2010Est. completion: Jun 2014120 patients
Phase 2Completed

Open Label Phase 1/2 Study of Tasquinimod in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (Post-PV MF), or Post-Essential Thrombocytosis Myelofibrosis (Post-ET MF)

Start: Aug 2024Est. completion: May 2031
Phase 1/2Recruiting

A Study of Fedratinib in Japanese Subjects With DIPSS (Dynamic International Prognostic Scoring System)- Intermediate or High-risk Primary Myelofibrosis (PMF), Post-polycythemia Vera Myelofibrosis (Post-PV MF), or Post-essential Thrombocythemia Myelofibrosis (Post-ET MF)

Start: Oct 2020Est. completion: Nov 202631 patients
Phase 1/2Active Not Recruiting
NCT01423058GSKMomelotinib

Safety Study Evaluating Twice-Daily Administration of Momelotinib in Primary Myelofibrosis or Post-Polycythemia Vera or Post-Essential Thrombocythemia Myelofibrosis

Start: Aug 2011Est. completion: Jun 201461 patients
Phase 1/2Completed

Safety and Efficacy Study of CYT387 in Primary Myelofibrosis (PMF) or Post-polycythemia Vera (PV) or Post-essential Thrombocythemia (ET)

Start: Nov 2009Est. completion: Apr 2012166 patients
Phase 1/2Completed
NCT02917096City TherapeuticsAllogeneic Hematopoietic Stem Cell Transplantation

Ruxolitinib Phosphate and Chemotherapy Given Before and After Reduced Intensity Donor Stem Cell Transplant in Treating Patients With Myelofibrosis

Start: Nov 2016Est. completion: Aug 2023
Phase 1Completed

A Post-Marketing Surveillance Study to Assess the Safety of Fedratinib in Korean Patients With Myelofibrosis

Start: Jun 2023Est. completion: Dec 2027137 patients
N/ARecruiting

Related Jobs in Hematology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
4 actively recruiting trials targeting 1,354 patients
Small Molecule is the dominant modality (100% of programs)
8 companies competing in this space