Myelofibrosis

Hematology
20
Pipeline Programs
10
Companies
22
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
5
8
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
788%
Monoclonal Antibody
113%
+ 12 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Karyopharm Therapeutics
4 programs
3
1
SelinexorPhase 31 trial
PacritinibPhase 2Small Molecule1 trial
SelinexorPhase 21 trial
Selinexor 60 mgPhase 21 trial
Active Trials
NCT07447817Not Yet RecruitingEst. May 2030
NCT04562870Active Not RecruitingEst. Sep 2026
NCT05980806RecruitingEst. Oct 2028
+1 more trials
GS
Gilead SciencesFOSTER CITY, CA
3 programs
2
1
SimtuzumabPhase 2Monoclonal Antibody4 trials
IdelalisibPhase 1Small Molecule1 trial
IdelalisibPhase 1Small Molecule
Active Trials
NCT02436135Terminated10Est. Nov 2017
NCT01672853Completed235Est. Aug 2016
NCT01769196Terminated544Est. Feb 2016
+2 more trials
M&
Merck & Co.RAHWAY, NJ
2 programs
1
1
BomedemstatPhase 2Small Molecule1 trial
BomedemstatPhase 1/2Small Molecule1 trial
Active Trials
NCT03136185CompletedEst. Mar 2022
NCT05569538UnknownEst. Dec 2025
Takeda
TakedaTOKYO, Japan
1 program
1
ElriterceptPhase 21 trial
Active Trials
NCT05037760Recruiting135Est. Feb 2030
Rigel Pharmaceuticals
Rigel PharmaceuticalsSOUTH SAN FRANCISCO, CA
1 program
1
FostamatinibPhase 2Small Molecule1 trial
Active Trials
NCT04543279TerminatedEst. Jul 2022
AT
Actuate TherapeuticsFORT WORTH, TX
1 program
1
RuxolitinibPhase 2Small Molecule1 trial
Active Trials
NCT04218071CompletedEst. Jan 2024
CT
6 programs
4
2
TQ05105 TabletsPhase 1/21 trial
TQ05105 tabletsPhase 1/21 trial
TQ05105Phase 11 trial
TQ05105 TabletsPhase 11 trial
TQ05105 TabletsPhase 11 trial
+1 more programs
Active Trials
NCT06598956CompletedEst. Aug 2025
NCT06388759TerminatedEst. Aug 2025
NCT05982106CompletedEst. Jul 2021
+3 more trials
Bristol Myers Squibb
1 program
1
SAR302503Phase 1/21 trial
Active Trials
NCT00724334Completed42Est. May 2014
Stemline Therapeutics
1 program
1
Tagraxofusp InjectionPhase 1/21 trial
Active Trials
NCT02268253Completed82Est. Mar 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Karyopharm TherapeuticsSelinexor
Karyopharm TherapeuticsPacritinib
Karyopharm TherapeuticsSelinexor 60 mg
Merck & Co.Bomedemstat
TakedaElritercept
Rigel PharmaceuticalsFostamatinib
Karyopharm TherapeuticsSelinexor
Actuate TherapeuticsRuxolitinib
Gilead SciencesSimtuzumab
Gilead SciencesSimtuzumab
Gilead SciencesSimtuzumab
Gilead SciencesSimtuzumab
Chia Tai TianQing Pharmaceutical GroupTQ05105 tablets
Chia Tai TianQing Pharmaceutical GroupTQ05105 Tablets
Merck & Co.Bomedemstat

Showing 15 of 22 trials with date data

Clinical Trials (22)

Total enrollment: 1,136 patients across 22 trials

Study of Selinexor in Combination With Ruxolitinib in Myelofibrosis

Start: Mar 2021Est. completion: Mar 2028
Phase 3Active Not Recruiting

Selinexor and Pacritinib in JAK Inhibitor-naïve MF Patients With Cytopenias

Start: May 2026Est. completion: May 2030
Phase 2Not Yet Recruiting

A Study of Selinexor Monotherapy in Subjects With JAK Inhibitor-naïve Myelofibrosis and Moderate Thrombocytopenia

Start: Apr 2024Est. completion: Oct 2028
Phase 2Recruiting

Bomedemstat (IMG-7289) Plus Ruxolitinib for Myelofibrosis

Start: Dec 2022Est. completion: Dec 2025
Phase 2Unknown

A Study of Elritercept Alone or Together With Ruxolitinib in Adults With Myelofibrosis

Start: Dec 2021Est. completion: Feb 2030135 patients
Phase 2Recruiting

Fostamatinib as a Single Agent or in Combination With Ruxolitinib for Treatment of Patients With Myelofibrosis With Severe Thrombocytopenia

Start: May 2021Est. completion: Jul 2022
Phase 2Terminated

A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis

Start: Mar 2021Est. completion: Sep 2026
Phase 2Active Not Recruiting

Actuate 1901: 9-ING-41 in Myelofibrosis

Start: Aug 2020Est. completion: Jan 2024
Phase 2Completed

Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC)

Start: Mar 2013Est. completion: Aug 2016235 patients
Phase 2Completed

Study to Assess the Efficacy and Safety of Simtuzumab (GS-6624) in Adults With Idiopathic Pulmonary Fibrosis (IPF)

Start: Jan 2013Est. completion: Feb 2016544 patients
Phase 2Terminated

Long-Term Safety Study of GS-6624 in Adults With Idiopathic Pulmonary Fibrosis (IPF)

Start: Oct 2012Est. completion: Feb 201634 patients
Phase 2Terminated

Efficacy and Safety of Simtuzumab in Adults With Primary, Post Polycythemia Vera or Post Essential Thrombocythemia Myelofibrosis

Start: Jun 2011Est. completion: Sep 201454 patients
Phase 2Completed

A Clinical Trial of TQ05105 Tablets Combined With TQB3909 Tablets in the Treatment of Myelofibrosis (MF)

Start: May 2024Est. completion: Dec 2025
Phase 1/2Terminated

A Clinical Trial of TQ05105 Tablets Combined With TQB3617 Capsules in the Treatment of Myelofibrosis (MF)

Start: Dec 2023Est. completion: Apr 2027
Phase 1/2Recruiting

Bomedemstat (IMG-7289/MK-3543) in Participants With Myelofibrosis (IMG-7289-CTP-102/MK-3543-002)

Start: Jul 2017Est. completion: Mar 2022
Phase 1/2Completed

Tagraxofusp (SL-401) in Participants With Chronic Myelomonocytic Leukemia (CMML) and Myelofibrosis (MF)

Start: Feb 2016Est. completion: Mar 202382 patients
Phase 1/2Completed

A Long-Term Study of the Effects of Orally Administered SAR302503 in Patients With Myelofibrosis

Start: Jul 2008Est. completion: May 201442 patients
Phase 1/2Completed

To Evaluate the Pharmacokinetics and Safety of TQ05105 Tablet in Renal Impairment Subjects

Start: Oct 2024Est. completion: Aug 2025
Phase 1Completed

A Study to Evaluate Drug-Drug Interaction of TQ05105 Tablets

Start: Sep 2023Est. completion: May 2024
Phase 1Completed

TQ05105 Tablet for Myelofibrosis Treatment in Ruxolitinib-Resistant or Intolerant Patients

Start: Aug 2022Est. completion: Aug 2025
Phase 1Terminated

To Evaluate the Effect of Food on the Pharmacokinetics of TQ05105 Tablets in Healthy Adult Subjects

Start: Jul 2021Est. completion: Jul 2021
Phase 1Completed

Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Idelalisib in Adults Receiving Ruxolitinib as Therapy for Primary, Post-Polycythemia Vera, or Post-Essential Thrombocythemia Myelofibrosis With Progressive or Relapsed Disease

Start: Jun 2015Est. completion: Nov 201710 patients
Phase 1Terminated

Related Jobs in Hematology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
3 actively recruiting trials targeting 1,136 patients
10 companies competing in this space