Primary Immune Thrombocytopenia (ITP)

Hematology
4
Pipeline Programs
3
Companies
19
Clinical Trials
4 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
0
4
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 3 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

argenx
argenxBelgium - Zwijnaarde
2 programs
2
Efgartigimod IVPhase 31 trial
efgartigimodPhase 31 trial
Active Trials
NCT06544499Recruiting69Est. Jun 2028
NCT04274452Withdrawn0Est. Sep 2021
H
HutchmedChina - Hong Kong
1 program
1
HMPL-523Phase 31 trial
Active Trials
NCT05029635Active Not Recruiting272Est. May 2025
Novartis
NovartisBASEL, Switzerland
1 program
1
IanalumabPhase 3Monoclonal Antibody5 trials
Active Trials
NCT07421167Not Yet Recruiting164Est. Aug 2030
NCT06711887Recruiting315Est. Jul 2032
NCT06411639Withdrawn0Est. Jun 2028
+2 more trials

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
NovartisIanalumab
argenxEfgartigimod IV
NovartisIanalumab
NovartisIanalumab
NovartisIanalumab
NovartisIanalumab
NovartisIanalumab
NovartisIanalumab
NovartisIanalumab
NovartisIanalumab
HutchmedHMPL-523
argenxefgartigimod
NovartisIanalumab
NovartisIanalumab
NovartisIanalumab

Showing 15 of 19 trials with date data

Clinical Trials (19)

Total enrollment: 4,269 patients across 19 trials

Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without Study Treatment Withdrawal in Participants With Lupus Nephritis (SIRIUS-LN Extension)

Start: May 2025Est. completion: Jul 2032315 patients
Phase 3Recruiting
NCT06544499argenxEfgartigimod IV

A Study to Assess the Efficacy and Safety of Efgartigimod IV in Adult Participants With Primary Immune Thrombocytopenia

Start: Oct 2024Est. completion: Jun 202869 patients
Phase 3Recruiting

Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

Start: May 2024Est. completion: Apr 2032550 patients
Phase 3Recruiting

A Randomized, Double-blind 2-arm NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome.

Start: Oct 2023Est. completion: Jul 2030612 patients
Phase 3Active Not Recruiting

Phase 3 Study to Evaluate Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 2)

Start: Apr 2023Est. completion: Apr 2029288 patients
Phase 3Active Not Recruiting

Phase 3 Study to Evaluate Two Regimens of Ianalumab on Top of Standard-of-care Therapy in Patients With Systemic Lupus Erythematosus (SIRIUS-SLE 1)

Start: Mar 2023Est. completion: Mar 2029436 patients
Phase 3Active Not Recruiting

Study of Ianalumab Versus Placebo in Addition to First-line Corticosteroids in Primary Immune Thrombocytopenia (ITP)

Start: Feb 2023Est. completion: Sep 2028226 patients
Phase 3Active Not Recruiting

A Study of Efficacy and Safety of Ianalumab in Previously Treated Patients With Warm Autoimmune Hemolytic Anemia

Start: Dec 2022Est. completion: Dec 202890 patients
Phase 3Active Not Recruiting

Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome

Start: Aug 2022Est. completion: May 2027506 patients
Phase 3Active Not Recruiting

Two-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome

Start: Jul 2022Est. completion: May 2027276 patients
Phase 3Active Not Recruiting

Phase III Study on HMPL-523 for Treatment of ITP

Start: Oct 2021Est. completion: May 2025272 patients
Phase 3Active Not Recruiting
NCT04274452argenxefgartigimod

A Study to Assess the Efficacy and Safety of Efgartigimod in Adult Patients With Primary Immune Thrombocytopenia (ITP)

Start: Jun 2020Est. completion: Sep 20210
Phase 3Withdrawn

A Study to Assess the Tolerability of Ianalumab (VAY736) With Investigator's Choice Thrombopoietin Receptor Agonist (IC TPO-RA) in Patients With Primary Immune Thrombocytopenia (ITP)

Start: Jun 2026Est. completion: Aug 2030164 patients
Phase 2Not Yet Recruiting

A Clinical Study to Evaluate Ianalumab in Participants With Diffuse Cutaneous Systemic Sclerosis

Start: Oct 2024Est. completion: Jul 2030200 patients
Phase 2Recruiting

Two-period Crossover Study to Demonstrate the Comparability of Pharmacokinetics of Subcutaneous Ianalumab Between 2mL Auto-injector/2mL PFS with1mL Pre-filled Syringe in Adult Participants With Autoimmune Disease

Start: Jul 2024Est. completion: Jan 2029155 patients
Phase 2Active Not Recruiting

A Study of Ianalumab (VAY736) in Patients With Primary Immune Thrombocytopenia (ITP) Previously Treated With at Least Two Lines of Therapies

Start: Aug 2023Est. completion: Mar 202941 patients
Phase 2Active Not Recruiting

Biopsy Based Study to Understand Mechanism of Action of Ianalumab in Salivary Glands and Explore Relationships With Clinical Assessments.

Start: Jul 2022Est. completion: Jan 202621 patients
Phase 2Completed

Pharmacokinetics Study of Ianalumab in Chinese Participants With Autoimmune Diseases

Start: Nov 2024Est. completion: Jun 20280
Phase 1Withdrawn

Study Comparing Two VAY736 Drug Products in Patients With Rheumatoid Arthritis

Start: Dec 2018Est. completion: Jul 202448 patients
Phase 1Completed

Related Jobs in Hematology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
4 actively recruiting trials targeting 4,269 patients
3 companies competing in this space