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Postpartum Depression

Neurology
5
Pipeline Programs
13
Companies
19
Clinical Trials
3 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
0
3
Early DiscoveryClinical DevelopmentMarket

Neurology is a $26.9B market dominated by a single blockbuster anticoagulant (ELIQUIS), representing a mature but consolidating therapeutic area.

$26.9B marketMature→ Stable30 products15 companies

Key Trends

  • Extreme market concentration: 68% of spending driven by one FXa inhibitor product
  • Psychiatric and migraine therapies emerging as secondary growth drivers
  • High clinical trial activity (8,279 trials) signals continued pipeline development

Career Verdict

Neurology offers solid career stability with good hiring demand, but limited upside growth—best suited for professionals seeking established market positions rather than emerging-area innovation.

AI-generated market analysis based on FDA, CMS, ClinicalTrials.gov, and hiring data

Market Leaders

#1ELIQUISStable
$18.3B
Bristol Myers Squibb·Launch15.0yr
$1.8B
#3BRILINTAStable
$692M
AstraZeneca·Peak10.2yr
#4NUPLAZIDStable
$596M
$530M
Johnson & Johnson·Peak15.6yr

Drug Class Breakdown

FXa Inhibitors (anticoagulant)
$18.3B(68%)

market-defining single product

Dopamine/Serotonin Antagonists (psychiatric)
$2.4B(9%)

stable mature class

P2Y12 Receptor Antagonists (antiplatelet)
$692M(3%)

niche but stable

5-HT2A Inverse Agonists (psychiatric)
$596M(2%)

specialty indication focus

CGRP Receptor Antagonists (migraine)
$931M(3%)

emerging growth segment

Immunomodulators (MS)
$747M(3%)

stable with LOE risk

Other mechanisms
$2.6B(10%)

diverse small products

Career Outlook

Stable

Neurology represents a mature, cash-generative market with limited growth tailwinds but strong hiring stability. The dominance of ELIQUIS creates a bifurcated career landscape: high-opportunity positions in emerging segments (CGRP antagonists, psychiatric therapeutics) and commoditized roles in anticoagulant franchises. Job availability is solid but growth expectations should be tempered relative to oncology or immunology.

Breaking In

Entry-level professionals should target clinical operations or commercial support roles at J&J, AstraZeneca, or Sanofi to build domain expertise in neurology disease states and competitive dynamics.

For Experienced Professionals

Experienced professionals should prioritize emerging mechanism roles (CGRP, tau-targeting programs) or pivot to medtech/neurotech (Stryker, Medtronic) to capture higher growth and salary potential than traditional pharma incumbents.

In-Demand Skills

Medical Science Liaisons (MSL) for specialist engagementClinical trial operations expertisePsychiatric/neurodegenerative disease educationRegulatory affairs (given patent cliff activity)Commercial strategy around branded/generic transitions

Best For

Medical Science LiaisonCommercial Brand Manager (anticoagulant/psychiatric franchises)Clinical Operations ManagerRegulatory Affairs SpecialistClinical Development Manager (CGRP/immunomodulator pipelines)

Hiring Landscape

$100K-$199K

Neurology shows moderate but distributed hiring across pharma and medtech employers, with 4,186 total jobs listed. Commercial functions lead (947 roles, $169K avg), followed by clinical operations (467 roles, $132K avg), indicating bias toward commercialization over R&D. Takeda leads external hiring (762 jobs) with strong representation in contract research and CRO spaces.

4,186
Open Roles
5
Companies Hiring
5
Departments

Top Hiring Companies

762Growing
434Stable
302Stable

By Department

Commercial(23%)
$169K
Clinical Operations(11%)
$132K
Engineering(8%)
$199K
IT(4%)
$100K
Manufacturing(3%)
$170K

Commercial and clinical operations roles dominate, offering stable mid-career positions; engineering roles command premium salaries ($199K), suggesting strong device/neurotech hiring pockets.

On Market (1)

Approved therapies currently available

Sage Therapeutics
ZULRESSOApproved
brexanolone
Sage Therapeutics
intravenous2019

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Supernus Pharmaceuticals
3 programs
1
1
ZULRESSO®Phase 41 trial
SAGE-547Phase 21 trial
ZULRESSON/A1 trial
Active Trials
NCT03924492Approved For Marketing
NCT02285504Completed4Est. Jun 2015
NCT05059600Completed52Est. Jul 2022
Sage Therapeutics
Sage TherapeuticsMA - Cambridge
2 programs
1
BrexanolonePhase 41 trial
BrexanoloneN/A1 trial
Active Trials
NCT05543746Completed10Est. Nov 2023
NCT04273191Withdrawn0Est. Aug 2021
Oregon Therapeutics
Oregon TherapeuticsFrance - Paris
1 program
1
Web-based CBT for PPDPhase 11 trial
Active Trials
NCT00942721Completed53Est. Apr 2013
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
3 programs
Circle of Security Parenting programN/A1 trial
MBCT-PDN/A1 trial
Smart BassinetN/A1 trial
Active Trials
NCT05772897Recruiting750Est. Jun 2035
NCT02387424Completed86Est. May 2013
NCT06544941Recruiting342Est. Jun 2028
Human BioSciences
Human BioSciencesWV - Martinsburg
2 programs
Cognitive Behavioral Therapy Intervention for AnxietyN/A1 trial
Mothers and BabiesN/A1 trial
Active Trials
NCT03880032Completed1,200Est. Oct 2022
NCT04296734Completed960Est. Jan 2024
Biogen
BiogenCAMBRIDGE, MA
2 programs
ZuranoloneN/A1 trial
SAGE-217 15/20 mg Oral SolutionPHASE_31 trial
Active Trials
NCT07398469Recruiting200Est. Mar 2027
NCT02978326Completed276Est. Dec 2018
Integrated Biosciences
Integrated BiosciencesCA - San Carlos
1 program
Goserelin 3.6 mg implantN/A1 trial
Active Trials
NCT02661789Completed63Est. Dec 2012
Alliance Pharmaceuticals
1 program
Leuprolide AcetateN/A1 trial
Active Trials
NCT01762943Completed36Est. Oct 2016
Labcorp
LabcorpBURLINGTON, NC
1 program
MamaLift PlusN/A
Innovation Pharmaceuticals
1 program
MamaLift PlusN/A1 trial
Active Trials
NCT05958095Unknown142Est. Aug 2023
IQVIA
IQVIADURHAM, NC
1 program
WB001N/A1 trial
Active Trials
NCT05551195Terminated7Est. May 2023
Brii Biosciences
Brii BiosciencesCA - San Mateo
1 program
BRII-297PHASE_11 trial
Active Trials
NCT05845840Completed41Est. Jan 2024
GH Research
GH ResearchDUBLIN 2, Ireland
1 program
GH001PHASE_21 trial
Active Trials
NCT05804708Terminated10Est. Nov 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Supernus PharmaceuticalsZULRESSO®
Sage TherapeuticsBrexanolone
BiogenSAGE-217 15/20 mg Oral Solution
GH ResearchGH001
Supernus PharmaceuticalsSAGE-547
Brii BiosciencesBRII-297
Oregon TherapeuticsWeb-based CBT for PPD
BiogenZuranolone
Colorado TherapeuticsSmart Bassinet
Colorado TherapeuticsCircle of Security Parenting program
Innovation PharmaceuticalsMamaLift Plus
IQVIAWB001
Sage TherapeuticsBrexanolone
Human BioSciencesMothers and Babies
Human BioSciencesCognitive Behavioral Therapy Intervention for Anxiety

Showing 15 of 18 trials with date data

Clinical Trials (19)

Total enrollment: 4,232 patients across 19 trials

A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting

Start: Oct 2021Est. completion: Jul 202252 patients
Phase 4Completed

A Study to Evaluate Multimodal Neuroimaging Parameters in Women With Postpartum Depression Who Are Receiving ZULRESSO™ (Brexanolone)

Start: Feb 2020Est. completion: Aug 20210
Phase 4Withdrawn
NCT02978326BiogenSAGE-217 15/20 mg Oral Solution

A Study to Evaluate SAGE-217 in Participants With Severe Postpartum Depression

Start: Jan 2017Est. completion: Dec 2018276 patients
Phase 3Completed

Phase 2 Clinical Trial of GH001 in Postpartum Depression

Start: Mar 2023Est. completion: Nov 202410 patients
Phase 2Terminated

Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression

Start: Jan 2015Est. completion: Jun 20154 patients
Phase 2Completed

A Study of BRII-297 in Healthy Adult Subjects

Start: May 2023Est. completion: Jan 202441 patients
Phase 1Completed
NCT00942721Oregon TherapeuticsWeb-based CBT for PPD

Cognitive Behavioral Therapy Delivered Over the Internet for Women With Postpartum Depression

Start: Oct 2009Est. completion: Apr 201353 patients
Phase 1Completed

Expanded Access Protocol of ZULRESSO™ (Brexanolone) Injection for Adult Patients With Postpartum Depression

N/AApproved For Marketing

A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone

Start: Dec 2025Est. completion: Mar 2027200 patients
N/ARecruiting

Improving Maternal Sleep and Mental Health

Start: Jan 2025Est. completion: Jun 2028342 patients
N/ARecruiting
NCT05772897Colorado TherapeuticsCircle of Security Parenting program

Parenting Skills Group for Mothers With Postpartum Depression

Start: Aug 2023Est. completion: Jun 2035750 patients
N/ARecruiting

Curio Digital Therapy for the Treatment of Post-partum Depression

Start: Apr 2023Est. completion: Aug 2023142 patients
N/AUnknown

[Study Evaluating the Efficacy and Safety of a Digital Therapeutic as an Adjunct to TAU in Postpartum Depression]

Start: Nov 2022Est. completion: May 20237 patients
N/ATerminated

Dynamic Neural Mechanisms of Brexanolone-induced Antidepressant Effects in Postpartum Depression

Start: Aug 2022Est. completion: Nov 202310 patients
N/ACompleted

Prenatal Depression Prevention Effects on Parenting and Young Child Self-Regulation and Functioning

Start: Nov 2019Est. completion: Jan 2024960 patients
N/ACompleted
NCT03880032Human BioSciencesCognitive Behavioral Therapy Intervention for Anxiety

Happy Mother-Healthy Baby: An Anxiety-focused Early Prenatal Intervention

Start: Apr 2019Est. completion: Oct 20221,200 patients
N/ACompleted

Neurophysiology of Postpartum Depression in an Experimental Model of Pregnancy and Parturition

Start: Aug 2013Est. completion: Oct 201636 patients
N/ACompleted
NCT02661789Integrated BiosciencesGoserelin 3.6 mg implant

Neuropsychobiological Correlates of Sex-steroid Hormone Manipulation in Healthy Women: a Risk Model for Depression

Start: Jan 2011Est. completion: Dec 201263 patients
N/ACompleted

Mindfulness-Based Cognitive Therapy for the Prevention of Perinatal Depressive Relapse/Recurrence

Start: Jul 2010Est. completion: May 201386 patients
N/ACompleted

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 actively recruiting trials targeting 4,232 patients
13 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.