PFIC - Progressive Familial Intrahepatic Cholestasis

Gastroenterology

Pipeline Programs

Companies

Clinical Trials

Approved Products

Pipeline by Development Stage

Preclinical

Phase 1

Phase 1/2

Phase 2

Phase 2/3

Phase 3

On Market

Early DiscoveryClinical DevelopmentMarket

Gastroenterology is a $7.3B market characterized by mature, blockbuster-driven portfolios with near-term patent cliff risks.

$7.3B marketMature→ Stable30 products15 companies

Key Trends

AbbVie dominance with 43% of top-10 product spending (LINZESS, CREON, RINVOQ)
Guanylate cyclase activators and JAK inhibitors driving innovation in constipation and IBD
Multiple patent expirations 2026–2030 creating biosimilar and generic erosion headwinds

Career Verdict

Gastroenterology offers stable, well-compensated roles but limited growth upside; best for risk-averse professionals seeking established markets over innovation-driven career trajectories.

AI-generated market analysis based on FDA, CMS, ClinicalTrials.gov, and hiring data

Market Leaders

#	Product	Company	Revenue	Share	Stage	Trend	LOE
1	LINZESS (linaclotide)	AbbVie	$1.8B	25%	Peak	Stable	7.7yr
2	CREON (pancrelipase)	AbbVie	$1.5B	21%	LOE Approaching	Declining
3	XIFAXAN (rifaximin)	Bausch Health	$1.1B	15%	LOE Approaching	Declining
4	RINVOQ (upadacitinib)	AbbVie	$976M	13%	Peak	Growing	11.8yr
5	XELJANZ XR (tofacitinib)	Pfizer	$586M	8%	Peak	Stable	8.3yr

#1LINZESS

$1.8B

AbbVie·Peak7.7yr

#2CREON

$1.5B

AbbVie·LOE Approaching

#3XIFAXAN

$1.1B

Bausch Health·LOE Approaching

#4RINVOQ

$976M

AbbVie·Peak11.8yr

#5XELJANZ XR

$586M

Pfizer·Peak8.3yr

Drug Class Breakdown

Unknown Mechanism

$2.5B(34%)

mature portfolio anchor

Guanylate Cyclase Activators

$1.9B(27%)

well-established class

Pancreatic Enzymes

$1.5B(20%)

facing biosimilar competition

Janus Kinase Inhibitors

$976M(13%)

growing IBD adoption

Proton Pump Inhibitors

$107M(1%)

commoditized

Career Outlook

Stable

Gastroenterology is a stable, mature market anchored by blockbusters with long patent runways (LINZESS to 2034, RINVOQ to 2038) but faces near-term erosion (XELJANZ 2026). Employment growth is modest and concentrated in device/diagnostic firms rather than pure-pharma. Best for professionals seeking predictable revenue streams over high-risk innovation bets.

Breaking In

Target roles at Roche, J&J, or diagnostic-adjacent firms to maximize hiring volume; pure pharma gastro entry points at AbbVie/Pfizer are limited and highly competitive.

For Experienced Professionals

Leverage gastro expertise in broader GI/immunology roles (Takeda, Novartis) or transition to medical devices/diagnostics where hiring is 3x higher than pharma.

In-Demand Skills

IBD and IBS indication expertiseJAK inhibitor pharmacologyMedical device integration (diagnostics, endoscopy)Generic/biosimilar launch readinessReal-world evidence generation

Best For

Medical Science Liaison (IBD/IBS focus)Commercial Manager (Generic Launch)Clinical Operations SpecialistMarket Access/Reimbursement StrategistRegulatory Affairs (small molecule focus)

Hiring Landscape

$70K-$213K

Total hiring across the gastro ecosystem is 1,818 jobs, dominated by engineering (434) and commercial roles (269). Roche leads absolute hiring at 377 roles, followed by Johnson & Johnson (323) and GE HealthCare (293), reflecting broad medical device and diagnostic involvement alongside pharma. AbbVie's gastro-specific hiring (78 jobs) is modest relative to its portfolio dominance.

1,818

Open Roles

Companies Hiring

Departments

Top Hiring Companies

377

323

293

By Department

Engineering(24%)

$169K

Commercial(15%)

$176K

Manufacturing(10%)

$213K

Manufacturing and commercial roles command premium salaries ($213K and $176K respectively), but total gastro-pharma hiring is concentrated in Roche and J&J, not pure-play GI companies.

Competitive Landscape

1 companies ranked by most advanced pipeline stage

Pre

P1/2

P2/3

Mkt

Mirum PharmaceuticalsFOSTER CITY, CA

1 program

Pediatric Evaluation and Registry for Liver Cholestasis in CanadaN/A1 trial

Active Trials

NCT07411716Not Yet Recruiting220Est. Dec 2031

Trial Timeline

Clinical trial activity over time

2026

2027

2028

2029

2030

2031

Mirum PharmaceuticalsPediatric Evaluation and Registry for Liver Cholestasis in Canada

Clinical Trials (1)

Total enrollment: 220 patients across 1 trials

NCT07411716 Mirum PharmaceuticalsPediatric Evaluation and Registry for Liver Cholestasis in Canada

Pediatric Evaluation and Registry for Liver Cholestasis in Canada

Start: Mar 2026Est. completion: Dec 2031220 patients

N/ANot Yet Recruiting

Related Jobs in Gastroenterology

Phase Legend

Preclinical— Lab & animal studies

Phase 1— Safety & dosing

Phase 2— Efficacy testing

Phase 3— Large-scale trials

On Market— Approved & available

Key Insights

2 companies competing in this space

Related Indications

Hepatic Impairment(157)Irritable Bowel Syndrome(76)Liver Transplantation(62)Gastroesophageal Reflux Disease(60)Gastroparesis(56)Liver Cirrhosis(48)Hepatic Insufficiency(48)Celiac Disease(45)Gastroesophageal Reflux(40)Cirrhosis(32)

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.