Overweight and Obesity

Metabolic Diseases
7
Pipeline Programs
10
Companies
16
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
1
0
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
3100%
+ 9 programs with unclassified modality

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
3 programs
1
1
semaglutide 50 mgPhase 3Peptide1 trial
NNC0174 0833Phase 11 trial
Nutritional Psycho-Behavioral Reeducation ProgramN/A1 trial
Active Trials
NCT05857319Not Yet Recruiting10,000Est. Jul 2030
NCT05254158Completed24Est. Sep 2022
NCT05132088Completed201Est. Sep 2023
Rhythm Pharmaceuticals
1 program
1
SetmelanotidePhase 1/2Peptide1 trial
Active Trials
NCT02041195Completed99Est. Dec 2014
Neuraly
NeuralyMD - Gaithersburg
1 program
1
DD01Phase 11 trial
Active Trials
NCT04812262CompletedEst. Feb 2023
35Pharma
35PharmaQC - Montreal
1 program
1
HS235Phase 11 trial
Active Trials
NCT06714825Completed39Est. Dec 2025
Laekna Therapeutics
Laekna TherapeuticsChina - Shanghai
1 program
1
LAE103 injectionPhase 11 trial
Active Trials
NCT07230496RecruitingEst. Mar 2028
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
Maridebart CafraglutidePhase 1Peptide1 trial
Active Trials
NCT07313761Recruiting340Est. Jun 2026
Alliance Pharmaceuticals
2 programs
Home weight loss programN/A1 trial
PotatoesN/A5 trials
Active Trials
NCT03439579Completed30Est. Sep 2018
NCT05610124Unknown30Est. Apr 2024
NCT05589467Completed26Est. Oct 2022
+3 more trials
Novartis
NovartisBASEL, Switzerland
1 program
High-calorie mealN/A1 trial
Active Trials
NCT04482738Completed36Est. Feb 2021
Precision BioSciences
1 program
Study product AN/A1 trial
Active Trials
NCT06030999Completed150Est. Dec 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Novo Nordisksemaglutide 50 mg
Alliance PharmaceuticalsPotatoes
Rhythm PharmaceuticalsSetmelanotide
Laekna TherapeuticsLAE103 injection
AmgenMaridebart Cafraglutide
35PharmaHS235
Novo NordiskNNC0174 0833
NeuralyDD01
Precision BioSciencesStudy product A
Novo NordiskNutritional Psycho-Behavioral Reeducation Program
Alliance PharmaceuticalsPotatoes
NovartisHigh-calorie meal
Alliance PharmaceuticalsPotatoes
Alliance PharmaceuticalsHome weight loss program
Alliance PharmaceuticalsPotatoes

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 11,090 patients across 16 trials

NCT05132088Novo Nordisksemaglutide 50 mg

Research Study to Investigate How Well Semaglutide Tablets Taken Once Daily Work in East Asian People Who Are Overweight or Living With Obesity

Start: Nov 2021Est. completion: Sep 2023201 patients
Phase 3Completed
NCT02697708Alliance PharmaceuticalsPotatoes

Retention of Potassium From Potatoes and Potassium Gluconate, and the Effect on Blood Pressure.

Start: Apr 2016Est. completion: Dec 201840 patients
Phase 1/2Unknown
NCT02041195Rhythm PharmaceuticalsSetmelanotide

Phase 1b/2a Study to Evaluate Safety and Efficacy of Setmelanotide in Obese Patients

Start: Jan 2014Est. completion: Dec 201499 patients
Phase 1/2Completed
NCT07230496Laekna TherapeuticsLAE103 injection

A Study to Investigate Safety, Tolerability and Pharmacokinetics of LAE103 or LAE103 in Combination With LAE102 in Healthy Overweight/Obese Participants

Start: Dec 2025Est. completion: Mar 2028
Phase 1Recruiting
NCT07313761AmgenMaridebart Cafraglutide

A Trial to Compare the Extent to Which Maridebart Cafraglutide (AMG 133) is Made Available in the Body When Administered Using Two Subcutaneous Presentations

Start: Dec 2025Est. completion: Jun 2026340 patients
Phase 1Recruiting
NCT0671482535PharmaHS235

Study of HS235 for Assessing the Pharmacokinetics, Safety, and Pharmacodynamics in Overweight/Obese Healthy Subjects

Start: Nov 2024Est. completion: Dec 202539 patients
Phase 1Completed
NCT05254158Novo NordiskNNC0174 0833

A Research Study of How NNC0174-0833 Behaves in Chinese Volunteers Who Are Normal Weight, Overweight or With Obesity

Start: Mar 2022Est. completion: Sep 202224 patients
Phase 1Completed
NCT04812262NeuralyDD01

A Phase 1 Study of DD01 in Overweight/Obese Subjects With T2DM and NAFLD

Start: Feb 2021Est. completion: Feb 2023
Phase 1Completed
NCT06030999Precision BioSciencesStudy product A

The Prevention And Treatment On Obesity And Weight Management By Oral Supplementation Of Probiotics And Prebiotics

Start: Sep 2023Est. completion: Dec 2023150 patients
N/ACompleted
NCT05857319Novo NordiskNutritional Psycho-Behavioral Reeducation Program

Study Consortium for Evaluation of RNPC Program in Obese and Overweight Patients (SCOOP-RNPC)

Start: Jul 2023Est. completion: Jul 203010,000 patients
N/ANot Yet Recruiting
NCT05610124Alliance PharmaceuticalsPotatoes

Postprandial Glycemia and Satiety of Meals With Potatoes, With and Without Protein

Start: Feb 2023Est. completion: Apr 202430 patients
N/AUnknown
NCT04482738NovartisHigh-calorie meal

Study of the Effects of Overfeeding on Glucocorticoids in Lean and Obese Subjects

Start: May 2020Est. completion: Feb 202136 patients
N/ACompleted
NCT05589467Alliance PharmaceuticalsPotatoes

Effects of Potatoes on Blood Pressure in Persons With and Without Type 2 Diabetes Who Follow the DASH Diet for 6 Weeks

Start: Jan 2020Est. completion: Oct 202226 patients
N/ACompleted
NCT03439579Alliance PharmaceuticalsHome weight loss program

Pilot Study of the HWL Program

Start: Feb 2018Est. completion: Sep 201830 patients
N/ACompleted
NCT03310476Alliance PharmaceuticalsPotatoes

Influence of Resistant Starch Intake in Potatoes on Blood Glucose and Satiety Responses in Overweight Females

Start: Jan 2018Est. completion: Aug 201930 patients
N/ACompleted
NCT01881295Alliance PharmaceuticalsPotatoes

Bioavailability of Potassium From Potatoes and Potassium Gluconate

Start: Mar 2013Est. completion: Dec 201445 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 11,090 patients
10 companies competing in this space

Related Indications

Diabetes(737)Diabetes Mellitus, Type 2(485)Obesity(246)Type 2 Diabetes(207)Type 2 Diabetes Mellitus(190)Diabetes Mellitus(127)Diabetes Mellitus, Type 1(95)Type 1 Diabetes Mellitus(51)Type 1 Diabetes(50)Dyslipidemia(45)