Non-Proliferative Diabetic Retinopathy

Ophthalmology
3
Pipeline Programs
2
Companies
3
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
2
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Alcon
AlconFORT WORTH, TX
2 programs
2
Nepafenac Ophthalmic Suspension, 0.3%Phase 31 trial
Nepafenac Ophthalmic Suspension, 0.3%Phase 31 trial
Active Trials
NCT01853072Completed881Est. May 2015
NCT01872611CompletedEst. May 2015
Valo Therapeutics
1 program
1
OPL-0401 Dose 1Phase 21 trial
Active Trials
NCT05393284Active Not RecruitingEst. Aug 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
AlconNepafenac Ophthalmic Suspension, 0.3%
AlconNepafenac Ophthalmic Suspension, 0.3%
Valo TherapeuticsOPL-0401 Dose 1

Clinical Trials (3)

Total enrollment: 881 patients across 3 trials

NCT01853072AlconNepafenac Ophthalmic Suspension, 0.3%

Nepafenac Once Daily for Macular Edema - Study 1

Start: Jun 2013Est. completion: May 2015881 patients
Phase 3Completed
NCT01872611AlconNepafenac Ophthalmic Suspension, 0.3%

Nepafenac Once Daily for Macular Edema - Study 2

Start: Jun 2013Est. completion: May 2015
Phase 3Completed
NCT05393284Valo TherapeuticsOPL-0401 Dose 1

Phase 2 Spectra Study to Evaluate the Safety and Efficacy of OPL-0401 in Patients With Diabetic Retinopathy

Start: Aug 2022Est. completion: Aug 2024
Phase 2Active Not Recruiting

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
2 companies competing in this space

Related Indications

Myopia(127)Cataract(116)Open-Angle Glaucoma(102)Glaucoma(92)Dry Eye(74)Age-Related Macular Degeneration(73)Dry Eye Disease(43)Neovascular Age-related Macular Degeneration(40)Macular Degeneration(37)Diabetic Retinopathy(25)