Neovascular Age-related Macular Degeneration (nAMD)
Ophthalmology
4
Pipeline Programs
5
Companies
5
Clinical Trials
2 recruiting
0
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
1
0
2
0
Early DiscoveryClinical DevelopmentMarket
Drug Modality Breakdown
Monoclonal Antibody
1100%
+ 4 programs with unclassified modality
Competitive Landscape
5 companies ranked by most advanced pipeline stage
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
2027
2028
2029
4D Molecular Therapeutics4D-150 IVT
SandozSOK583A1
AbbVieRanibizumab
AlconAR-14034 SR implant lower dose
BayerAflibercept
Clinical Trials (5)
Total enrollment: 3,626 patients across 5 trials
Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration
Start: Jul 2025Est. completion: Feb 2029480 patients
Phase 3Recruiting
Study of the Safety of Use of Intravitreal SOK583A1 Provided in a Vial Kit
Start: May 2022Est. completion: Sep 2022
Phase 3Completed
RGX-314 Gene Therapy Administered in the Suprachoroidal Space for Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Start: Aug 2020Est. completion: Feb 2027146 patients
Phase 2Active Not Recruiting
Study of AR-14034 in Participants With Neovascular Age-Related Macular Degeneration (nAMD)
Start: Dec 2023Est. completion: Oct 2027
Phase 1/2Recruiting
A Study to Learn More About the Use of Aflibercept in Routine Medical Practice in Japanese Participants With Neovascular Age-related Macular Degeneration and Diabetic Macular Edema
Start: Apr 2025Est. completion: Jul 20273,000 patients
N/AActive Not Recruiting
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Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
2 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 3,626 patients
5 companies competing in this space