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Multiple Sclerosis, Relapsing-Remitting

Neurology
28
Pipeline Programs
28
Companies
50
Clinical Trials
1 recruiting
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
1
12
1
3
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
11100%
+ 55 programs with unclassified modality

Neurology is a $26.9B market dominated by a single blockbuster anticoagulant (ELIQUIS), representing a mature but consolidating therapeutic area.

$26.9B marketMature→ Stable30 products15 companies

Key Trends

  • Extreme market concentration: 68% of spending driven by one FXa inhibitor product
  • Psychiatric and migraine therapies emerging as secondary growth drivers
  • High clinical trial activity (8,279 trials) signals continued pipeline development

Career Verdict

Neurology offers solid career stability with good hiring demand, but limited upside growth—best suited for professionals seeking established market positions rather than emerging-area innovation.

AI-generated market analysis based on FDA, CMS, ClinicalTrials.gov, and hiring data

Market Leaders

#1ELIQUISStable
$18.3B
Bristol Myers Squibb·Launch15.0yr
$1.8B
#3BRILINTAStable
$692M
AstraZeneca·Peak10.2yr
#4NUPLAZIDStable
$596M
$530M
Johnson & Johnson·Peak15.6yr

Drug Class Breakdown

FXa Inhibitors (anticoagulant)
$18.3B(68%)

market-defining single product

Dopamine/Serotonin Antagonists (psychiatric)
$2.4B(9%)

stable mature class

P2Y12 Receptor Antagonists (antiplatelet)
$692M(3%)

niche but stable

5-HT2A Inverse Agonists (psychiatric)
$596M(2%)

specialty indication focus

CGRP Receptor Antagonists (migraine)
$931M(3%)

emerging growth segment

Immunomodulators (MS)
$747M(3%)

stable with LOE risk

Other mechanisms
$2.6B(10%)

diverse small products

Career Outlook

Stable

Neurology represents a mature, cash-generative market with limited growth tailwinds but strong hiring stability. The dominance of ELIQUIS creates a bifurcated career landscape: high-opportunity positions in emerging segments (CGRP antagonists, psychiatric therapeutics) and commoditized roles in anticoagulant franchises. Job availability is solid but growth expectations should be tempered relative to oncology or immunology.

Breaking In

Entry-level professionals should target clinical operations or commercial support roles at J&J, AstraZeneca, or Sanofi to build domain expertise in neurology disease states and competitive dynamics.

For Experienced Professionals

Experienced professionals should prioritize emerging mechanism roles (CGRP, tau-targeting programs) or pivot to medtech/neurotech (Stryker, Medtronic) to capture higher growth and salary potential than traditional pharma incumbents.

In-Demand Skills

Medical Science Liaisons (MSL) for specialist engagementClinical trial operations expertisePsychiatric/neurodegenerative disease educationRegulatory affairs (given patent cliff activity)Commercial strategy around branded/generic transitions

Best For

Medical Science LiaisonCommercial Brand Manager (anticoagulant/psychiatric franchises)Clinical Operations ManagerRegulatory Affairs SpecialistClinical Development Manager (CGRP/immunomodulator pipelines)

Hiring Landscape

$100K-$199K

Neurology shows moderate but distributed hiring across pharma and medtech employers, with 4,186 total jobs listed. Commercial functions lead (947 roles, $169K avg), followed by clinical operations (467 roles, $132K avg), indicating bias toward commercialization over R&D. Takeda leads external hiring (762 jobs) with strong representation in contract research and CRO spaces.

4,186
Open Roles
5
Companies Hiring
5
Departments

Top Hiring Companies

762Growing
434Stable
302Stable

By Department

Commercial(23%)
$169K
Clinical Operations(11%)
$132K
Engineering(8%)
$199K
IT(4%)
$100K
Manufacturing(3%)
$170K

Commercial and clinical operations roles dominate, offering stable mid-career positions; engineering roles command premium salaries ($199K), suggesting strong device/neurotech hiring pockets.

On Market (3)

Approved therapies currently available

Sanofi
LEMTRADAApproved
alemtuzumab
Sanofi
CD52-directed Cytolytic Antibody [EPC]injection2001
909K Part D
Roche
OCREVUS ZUNOVOApproved
ocrelizumab and hyaluronidase
Roche
Endoglycosidase [EPC]injection2024
Sanofi
CAMPATHApproved
alemtuzumab
Sanofi
CD52-directed Cytolytic Antibody [EPC]intravenous2001

Competitive Landscape

26 companies ranked by most advanced pipeline stage

Bayer
BayerLEVERKUSEN, Germany
10 programs
3
3
1
Betaferon/BetaseronPhase 41 trial
AlemtuzumabPhase 3Monoclonal Antibody1 trial
Alemtuzumab 12 mgPhase 31 trial
alemtuzumabPhase 3Monoclonal Antibody1 trial
Interferon beta 1bPhase 21 trial
+5 more programs
Active Trials
NCT01158183Completed226Est. Sep 2009
NCT00888277Completed74Est. Jan 2010
NCT01071694Withdrawn0Est. Dec 2012
+7 more trials
Sandoz
SandozAustria - Kundl
3 programs
1
fingolimodPhase 41 trial
A Canadian Study of Persistence on Ofatumumab Using Patient Support Program DataN/A1 trial
OfatumumabN/AMonoclonal Antibody1 trial
Active Trials
NCT06854341Completed5,448Est. Aug 2024
NCT06345157Active Not Recruiting379Est. Jun 2026
NCT01420055Completed189Est. Jun 2013
Sanofi
SanofiPARIS, France
2 programs
1
Clinical assessmentN/A1 trial
alemtuzumabPHASE_3Monoclonal Antibody
Active Trials
NCT03768648Completed75Est. Feb 2023
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
OCREVUS ZUNOVO(Ocrelizumab)PHASE_3Monoclonal Antibody
Biocad
BiocadRussia - St. Petersburg
1 program
1
BCD-054 180 mcgPhase 2/31 trial
Active Trials
NCT02744222Completed399Est. Jul 2020
ViiV Healthcare
ViiV HealthcareNC - Durham
7 programs
5
2
GSK239512Phase 2
SB683699Phase 2
APhase 1
Firategrast immediate release tabletPhase 1
GSK1223249Phase 1
+2 more programs
Servier
ServierFrance - Suresnes
2 programs
2
GNbAC1Phase 21 trial
GNbAC1 Monoclonal AntibodyPhase 21 trial
Active Trials
NCT02782858Completed270Est. Dec 2017
NCT03239860Terminated220Est. Nov 2018
GeNeuro
GeNeuroSwitzerland - Geneva
2 programs
2
GNbAC1Phase 2
GNbAC1 Monoclonal AntibodyPhase 2
Pfizer
PfizerNEW YORK, NY
1 program
1
CCI-779Phase 21 trial
Active Trials
NCT00228397Completed221Est. Nov 2005
RemeGen
RemeGenChina - Yantai
1 program
1
RC18 160mgPhase 21 trial
Active Trials
NCT04625153Terminated8Est. Apr 2026
Kite Pharma
Kite PharmaCA - El Segundo
1 program
1
TENOFOVIR ALAFENAMIDE FUMARATE 25 Mg ORAL TABLET [VEMLIDY]Phase 21 trial
Active Trials
NCT04880577Withdrawn0Est. Feb 2025
Eppendorf
EppendorfGermany - Hamburg
2 programs
1
ETIMSPhase 1/21 trial
web-based intervention programmeN/A1 trial
Active Trials
NCT04233970Completed160Est. May 2023
NCT01414634Completed9Est. Oct 2012
FibroBiologics
FibroBiologicsTX - Houston
1 program
1
Tolerogenic FibroblastsPhase 11 trial
Active Trials
NCT05080270Completed5Est. Jun 2021
Biogen
BiogenCAMBRIDGE, MA
13 programs
Dimethyl FumarateN/A1 trial
Natalizumab Injection [Tysabri]N/A1 trial
SC Peginterferon beta-1aN/A1 trial
dimethyl fumarateN/A1 trial
dimethyl fumaratePHASE_21 trial
+8 more programs
Active Trials
NCT04221191Completed353Est. Sep 2022
NCT04580381Completed500Est. Oct 2021
NCT03347370Completed626Est. Jul 2019
+10 more trials
GSK
GSKLONDON, United Kingdom
3 programs
APHASE_11 trial
Firategrast immediate release tabletPHASE_11 trial
SB683699PHASE_21 trial
Active Trials
NCT01424462Completed20Est. Jul 2010
NCT01416363Completed38Est. Sep 2011
NCT00097331Completed261Est. Jul 2006
Bristol Myers Squibb
2 programs
A Post-Authorization, Long-term Study of Ozanimod Real-world SafetyN/A1 trial
ZeposiaN/A1 trial
Active Trials
NCT05605782Active Not Recruiting9,000Est. Jul 2033
NCT04885894Unknown60Est. Dec 2024
Providence Therapeutics
2 programs
Blood DrawN/A1 trial
ACTHPHASE_31 trial
Active Trials
NCT01909492Completed30Est. Oct 2023
NCT02315872Completed8Est. Dec 2018
Merck & Co.
Merck & Co.RAHWAY, NJ
2 programs
RebiSmart®2.0N/A1 trial
Cladribine 10 mg oral tabletPHASE_41 trial
Active Trials
NCT02394782Terminated8Est. Mar 2016
NCT05902429Unknown10Est. Aug 2024
Gilead Sciences
Gilead SciencesFOSTER CITY, CA
2 programs
TENOFOVIR ALAFENAMIDE FUMARATE 25 Mg ORAL TABLET [VEMLIDY]PHASE_2
TENOFOVIR ALAFENAMIDE FUMARATE 25 Mg ORAL TABLET [VEMLIDY]PHASE_2
Genentech
GenentechCA - Oceanside
2 programs
OcrelizumabPHASE_4Monoclonal Antibody1 trial
OcrelizumabPHASE_4Monoclonal Antibody1 trial
Active Trials
NCT06495593Enrolling By Invitation5Est. Jun 2027
NCT04261790Completed10Est. Nov 2024
Takeda
TakedaTOKYO, Japan
1 program
ACTOSPHASE_12 trials
Active Trials
NCT04943991Active Not Recruiting200Est. Oct 2024
NCT00242177Completed30Est. Oct 2005
Genesis Therapeutics
Genesis TherapeuticsCA - Burlingame
1 program
Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem CellsPHASE_1_21 trial
Active Trials
NCT02418325TerminatedEst. Feb 2017
Grifols
GrifolsNEW YORK, NY
1 program
Immune Globulin IV [Human], 10% Caprylate/Chromatography PurifiedPHASE_21 trial
Active Trials
NCT00220779Completed128Est. Feb 2005
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
abataceptPHASE_21 trial
Active Trials
NCT01116427Completed65Est. Feb 2015
Ipsen
IpsenChina - Tianjin
1 program
EGb 761®PHASE_31 trial
Active Trials
NCT00276341Completed47Est. Dec 2005
Immunic Therapeutics
Immunic TherapeuticsGermany - Grafelfing
1 program
IMU-838 tabletsPHASE_31 trial
Active Trials
NCT05201638Active Not Recruiting1,100Est. Oct 2033

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
GenentechOcrelizumab
BiogenNatalizumab
Merck & Co.Cladribine 10 mg oral tablet
GenentechOcrelizumab
Sandozfingolimod
BayerBetaferon/Betaseron
Immunic TherapeuticsIMU-838 tablets
BiogenDimethyl Fumarate
BiogenNatalizumab
Biogendimethyl fumarate
Biogendimethyl fumarate
Providence TherapeuticsACTH
Biogendimethyl fumarate
Bayeralemtuzumab
BayerAlemtuzumab 12 mg

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 26,497 patients across 50 trials

Effects of Ocrelizumab Treatment on Immune Cells in Lymph Nodes in Multiple Sclerosis

Start: Feb 2025Est. completion: Jun 20275 patients
Phase 4Enrolling By Invitation

A Study to Investigate the Radiological Onset of Action After Treatment Initiation With Subcutaneous (SC) Natalizumab in Participants With Relapsing-Remitting Multiple Sclerosis (RRMS)

Start: Jan 2023Est. completion: Oct 20231 patients
Phase 4Terminated
NCT05902429Merck & Co.Cladribine 10 mg oral tablet

Effects of Oral Cladribine on Remyelination and Inflammation in Multiple Sclerosis Patients

Start: Apr 2021Est. completion: Aug 202410 patients
Phase 4Unknown

Effects of Ocrelizumab on B-cell Tolerance Defect in Relapsing Multiple Sclerosis

Start: Aug 2020Est. completion: Nov 202410 patients
Phase 4Completed

Fingolimod -Response According to Coping - Evaluation

Start: Aug 2011Est. completion: Jun 2013189 patients
Phase 4Completed
NCT00206648BayerBetaferon/Betaseron

An Efficacy and Safety Comparison Study of Two Marketed Drugs in Patients With Relapsing-remitting MS

Start: Mar 2003Est. completion: Oct 2005271 patients
Phase 4Completed

Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 in Patients With Relapsing Multiple Sclerosis

Start: Jan 2022Est. completion: Oct 20331,100 patients
Phase 3Active Not Recruiting
NCT03870763BiogenDimethyl Fumarate

Study to Evaluate the Efficacy and Safety of Dimethyl Fumarate (Tecfidera) and Peginterferon Beta-1a (Plegridy) for the Treatment of Relapsing-Remitting Multiple Sclerosis in Pediatric Participants

Start: Mar 2019Est. completion: Jul 202211 patients
Phase 3Terminated

A Study to Evaluate Efficacy, Safety, and Tolerability of EID of Natalizumab (BG00002) in Participants With RRMS Switching From Treatment With Natalizumab SID in Relation to Continued SID Treatment- Followed by Extension Study Comprising SC and IV Natalizumab Administration

Start: Nov 2018Est. completion: Jul 2023585 patients
Phase 3Completed
NCT02555215Biogendimethyl fumarate

Extension Study of BG00012 in Pediatric Subjects With Relapsing Remitting Multiple Sclerosis (RRMS)

Start: Feb 2016Est. completion: Sep 201820 patients
Phase 3Completed
NCT02525874Biogendimethyl fumarate

Effect of BG00012 on Lymphocyte Subsets and Immunoglobulins in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS).

Start: Aug 2015Est. completion: Apr 2018218 patients
Phase 3Completed

ACTH for Fatigue in Multiple Sclerosis Patients

Start: May 2015Est. completion: Dec 20188 patients
Phase 3Completed
NCT02579681Biogendimethyl fumarate

Study Assessing Cognition in Relapsing Remitting Multiple Sclerosis (RRMS) Patients Treated With BG00012

Start: Apr 2014Est. completion: Dec 2016221 patients
Phase 3Completed
NCT00930553Bayeralemtuzumab

An Extension Protocol for Multiple Sclerosis Patients Who Participated in Genzyme-Sponsored Studies of Alemtuzumab

Start: Aug 2009Est. completion: Feb 20161,314 patients
Phase 3Completed
NCT00548405BayerAlemtuzumab 12 mg

Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study Two

Start: Oct 2007Est. completion: Sep 2011840 patients
Phase 3Completed
NCT00530348BayerAlemtuzumab

Comparison of Alemtuzumab and Rebif® Efficacy in Multiple Sclerosis, Study One

Start: Aug 2007Est. completion: Apr 2011581 patients
Phase 3Completed

Study on the Effectiveness of EGb 761® vs Placebo Used for Cognitive Impairment in Patients With Multiple Sclerosis

Start: Aug 2003Est. completion: Dec 200547 patients
Phase 3Completed

Safety and Efficacy of Natalizumab in Combination With Avonex in the Treatment of Multiple Sclerosis

Start: Jan 2002Est. completion: Dec 20051,200 patients
Phase 3Completed

Safety and Efficacy of Natalizumab in the Treatment of Multiple Sclerosis

Start: Nov 2001Est. completion: Jan 2005900 patients
Phase 3Completed
NCT02744222BiocadBCD-054 180 mcg

Comparative Clinical Trial to Evaluate Efficacy, Safety and Tolerance of BCD-054 and Avonex® for Treatment of Patients With Remitting-relapsing Multiple Sclerosis

Start: Aug 2017Est. completion: Jul 2020399 patients
Phase 2/3Completed
NCT04880577Kite PharmaTENOFOVIR ALAFENAMIDE FUMARATE 25 Mg ORAL TABLET [VEMLIDY]

Tenofovir Alafenamide for Treatment of Symptoms and Neuroprotection in Relapsing Remitting Multiple Sclerosis

Start: Sep 2022Est. completion: Feb 20250
Phase 2Withdrawn

RC18 in Patients With Relapsing Remitting Multiple Sclerosis:a Phase II Trial

Start: May 2021Est. completion: Apr 20268 patients
Phase 2Terminated
NCT03910738BayerNebido® Testosterone Undecanoate 1000 Mg/4 mL Solution for Injection

TOTEM RRMS : TestOsterone TreatmEnt on Neuroprotection and Myelin Repair in Relapsing Remitting Multiple Sclerosis

Start: Oct 2019Est. completion: Dec 202740 patients
Phase 2Recruiting
NCT03239860ServierGNbAC1 Monoclonal Antibody

Assessing the HERV-W Env ANtagonist GNbAC1 for Evaluation in an Open Label Long-term Safety Study in Patients With Multiple Sclerosis

Start: Jun 2017Est. completion: Nov 2018220 patients
Phase 2Terminated

Clinical Trial Assessing the HERV-W Env Antagonist GNbAC1 for Efficacy in MS

Start: Apr 2016Est. completion: Dec 2017270 patients
Phase 2Completed
NCT02410200Biogendimethyl fumarate

Study of the Effect of BG00012 on MRI Lesions and Pharmacokinetics in Pediatric Subjects With RRMS

Start: Sep 2015Est. completion: Sep 201622 patients
Phase 2Completed

A Cooperative Clinical Study of Abatacept in Multiple Sclerosis

Start: Sep 2010Est. completion: Feb 201565 patients
Phase 2Completed

Three Months Treatment With SB683699 In Patients With Relapsing Multiple Sclerosis

Start: Sep 2004Est. completion: Jul 2006261 patients
Phase 2Completed

Study Evaluating CCI-779 in Relapsing Multiple Sclerosis

Start: Nov 2003Est. completion: Nov 2005221 patients
Phase 2Completed
NCT00235989BayerInterferon beta 1b

Extension of Prior Study Evaluating Safety and Tolerability of Two Doses of Betaseron® to Treat Relapsing-remitting Multiple Sclerosis

Start: Jun 2003Est. completion: Jan 200863 patients
Phase 2Completed
NCT00050778BayerInterferon beta-1a

A Phase II Study Comparing Low- and High-Dose Alemtuzumab and High-Dose Rebif® in Patients With Early, Active Relapsing-Remitting Multiple Sclerosis

Start: Dec 2002Est. completion: Jan 2010334 patients
Phase 2Completed
NCT00220779GrifolsImmune Globulin IV [Human], 10% Caprylate/Chromatography Purified

Immune Globulin Intravenous (IGIV) To Treat Relapsing, Remitting Multiple Sclerosis

Start: Dec 2002Est. completion: Feb 2005128 patients
Phase 2Completed
NCT02418325Genesis TherapeuticsAllogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells

A Study of Allogeneic Human UC-MSC and Liberation Therapy (When Associated With CCSVI) in Patients With RRMS

Start: Feb 2015Est. completion: Feb 2017
Phase 1/2Terminated

Establish Tolerance In MS With Peptide-Coupled, Peripheral Blood Mononuclear Cells

Start: Feb 2010Est. completion: Oct 20129 patients
Phase 1/2Completed
NCT05080270FibroBiologicsTolerogenic Fibroblasts

Feasibility Study of Tolerogenic Fibroblasts in Patients With Refractory Multiple Sclerosis

Start: Sep 2020Est. completion: Jun 20215 patients
Phase 1Completed
NCT01416363GSKFirategrast immediate release tablet

Healthy Volunteer Study Using 3 Different Formulations of Firategrast

Start: May 2011Est. completion: Sep 201138 patients
Phase 1Completed

Healthy Volunteer Pilot Study Using 3 Types of Modified Release Formulations of Firategrast to Investigate How Quickly Absorption From the Digestive System Takes Place.

Start: Apr 2010Est. completion: Jul 201020 patients
Phase 1Completed

Pilot Test of ACTOS in Multiple Sclerosis: Safety and Tolerability

Start: Oct 2003Est. completion: Oct 200530 patients
Phase 1Completed

ITAKOS - Italian Observation, Multicenter, Prospective Study of Ofatumumab in RRMS Patients

Start: Jul 2024Est. completion: Jun 2026379 patients
N/AActive Not Recruiting
NCT06854341SandozA Canadian Study of Persistence on Ofatumumab Using Patient Support Program Data

A Canadian Study of Persistence on Ofatumumab Using Patient Support Program Data

Start: Feb 2024Est. completion: Aug 20245,448 patients
N/ACompleted

An Examination of Cognitive Fatigue Using Functional Neuroimaging

Start: Jan 2022Est. completion: Dec 202460 patients
N/AUnknown
NCT05605782Bristol Myers SquibbA Post-Authorization, Long-term Study of Ozanimod Real-world Safety

A Post-Authorization, Long-term Study of Ozanimod Real-world Safety

Start: Sep 2021Est. completion: Jul 20339,000 patients
N/AActive Not Recruiting

Fabry Disease in High-risk Patients With Left Ventricular Hypertrophy: Prevalence and Implementation of a Clinical Score

Start: Jul 2021Est. completion: Oct 2024200 patients
N/AActive Not Recruiting
NCT04580381BiogenNatalizumab Injection [Tysabri]

Real World Effectiveness of Natalizumab Extended Interval Dosing in a French Cohort

Start: Sep 2020Est. completion: Oct 2021500 patients
N/ACompleted
NCT04233970Eppendorfweb-based intervention programme

Development and Evaluation of a Web-based Programme on Relapse Management for People With Multiple Sclerosis

Start: Feb 2020Est. completion: May 2023160 patients
N/ACompleted
NCT04221191BiogenDimethyl Fumarate

Dimethyl Fumarate (DMF, Tecfidera®) Persistence in RR-MS Patients Included in the French Patient Support Program OroSEP

Start: Aug 2019Est. completion: Sep 2022353 patients
N/ACompleted
NCT03768648SanofiClinical assessment

Cognition and MRI Markers in MS Patients With Aubagio® Treatment

Start: May 2019Est. completion: Feb 202375 patients
N/ACompleted
NCT03347370BiogenSC Peginterferon beta-1a

A Post-Authorization Safety Study of Interferon Beta Therapy in Participants With Multiple Sclerosis

Start: Nov 2017Est. completion: Jul 2019626 patients
N/ACompleted
NCT02323269Biogendimethyl fumarate

Effectiveness of DMF (Dimethyl Fumarate) and Its Impact on PROs (Patient Reported Outcomes) in Treatment-Naive or Suboptimal IFN (Interferon) or GA (Glatiramer Acetate) Responders With RRMS (ImPROve)

Start: May 2015Est. completion: Mar 201624 patients
N/ATerminated

Observational Study of Rebismart®2.0 + MSdialog™ in Subjects With Remitting Multiple Sclerosis (ADHERQOL)

Start: Feb 2015Est. completion: Mar 20168 patients
N/ATerminated

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 26,497 patients
28 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.