Mild to Moderate Hypertension

Cardiovascular
2
Pipeline Programs
2
Companies
16
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Novartis
NovartisBASEL, Switzerland
1 program
1
LCZ696Phase 25 trials
Active Trials
NCT03909295Terminated52Est. Nov 2019
NCT02687932Completed118Est. Jan 2018
NCT02661217Completed1,002Est. Jun 2018
+2 more trials
Alnylam Pharmaceuticals
1 program
1
ZilebesiranPhase 1/21 trial
Active Trials
NCT06423352Completed36Est. Jul 2025

Trial Timeline

Clinical trial activity over time

2021
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2026
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Alnylam PharmaceuticalsZilebesiran

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 15,275 patients across 16 trials

Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation

Start: Mar 2016Est. completion: Jan 2018118 patients
Phase 4Completed

Comparison of Pre- and Post-discharge Initiation of LCZ696 Therapy in HFrEF Patients After an Acute Decompensation Event

Start: Feb 2016Est. completion: Jun 20181,002 patients
Phase 4Completed

An Open-label Extension Study Evaluating Safety and Tolerability of LCZ696 in Subjects Who Completed PARAGON-HF in Japan.

Start: May 2019Est. completion: Nov 201952 patients
Phase 3Terminated

Efficacy and Safety of LCZ696 Compared to Valsartan, on Morbidity and Mortality in Heart Failure Patients With Preserved Ejection Fraction

Start: Jul 2014Est. completion: Jun 20194,822 patients
Phase 3Completed

Safety and Tolerability and Efficacy of LCZ696 in Japanese Severe Hypertensive Patients

Start: Jul 2012Est. completion: Feb 201335 patients
Phase 3Completed

Safety and Tolerability and Efficacy of LCZ696 in Japanese Hypertensive Patients With Renal Dysfunction

Start: May 2012Est. completion: Mar 201332 patients
Phase 3Completed

This Study Will Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure

Start: Dec 2009Est. completion: May 20148,442 patients
Phase 3Terminated

Safety and Tolerability of Initiating LCZ696 in Heart Failure Patients

Start: Nov 2013Est. completion: Aug 2014498 patients
Phase 2Completed

Evaluation of Drug-drug Interaction Between LCZ696 and Sildenafil in Subjects With Mild to Moderate Hypertension

Start: Sep 2012Est. completion: Jan 201328 patients
Phase 2Completed

A Study of LCZ696 in Subjects With Mild and Moderate Hepatic Impairment Compared With Normal Healthy Volunteers

Start: Sep 2012Est. completion: Jan 201332 patients
Phase 2Completed

Assessment of LCZ696 and Valsartan in Asian Patients With Salt-sensitive Hypertension

Start: Aug 2012Est. completion: Oct 201372 patients
Phase 2Completed

Sodium Excretion of LCZ696 in Patients With Hypertension; Heart Failure and Healthy Volunteers

Start: Mar 2011Est. completion: Aug 201232 patients
Phase 2Completed

Safety/Tolerability, Pharmacokinetics/Pharmacodynamics (PK/PD) of LCZ696 in Patients With Stable Heart Failure

Start: May 200930 patients
Phase 2Completed

Multiple Dose Pharmacokinetics of LCZ696 and Its Metabolites in Subjects With Severe Renal Impairment vs. Matched Healthy Subjects With Normal Renal Function

Start: Mar 2009Est. completion: Sep 200912 patients
Phase 2Completed

A Study to Evaluate Zilebesiran in Japanese Patients With Mild to Moderate Hypertension

Start: Jun 2024Est. completion: Jul 202536 patients
Phase 1/2Completed

Pharmacokinetics of LCZ696 in Subjects With Mild and Moderate Renal Impairment Compared to Healthy Subjects With Normal Renal Function

Start: Feb 2009Est. completion: Aug 201432 patients
Phase 1Completed

Related Jobs in Cardiovascular

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

2 companies competing in this space