Alnylam Pharmaceuticals(ALNY)

CAMBRIDGE, MAPharmaceutical3 H-1B visas (FY2023)

Focus: Alnylam is a public specialty pharma company focused on RNAi therapeutics for rare genetic and complex diseases, with a commercial footprint anchored by AMVUTTRA (vutrisiran) for transthyretin amyloidosis. The company operates as a scaled late-stage biotech with $1.8B in FY2025 revenue and a 55% R&D intensity.

Gene Therapy Neurology

Profile data last refreshed 10h ago · AI intelligence enriched 2mo ago

Funding Stage

PUBLIC

Total Funding

$250M

Open Jobs

Should You Work at Alnylam Pharmaceuticals?

AI assessment

Best fit for early-to-mid career scientists and commercial professionals seeking a rare-disease specialist with proven drug approvals and emerging pipeline depth, provided you accept single-product revenue risk and willingness to navigate potential restructuring if pipeline phase-outs accelerate.

Why Work Here

Leadership in validated RNAi platform with 4 approved products (AMVUTTRA, GIVLAARI, ONPATTRO, OXLUMO) generating $1.8B revenue, demonstrating durable commercial traction

Data completeness

7/9 — Strong

Company HealthStrong

Pipeline

Early-stage

50 total

LOE Risk

Protected

No near-term cliffs

Hiring

Stable

Revenue

$1.8B

Key Products

AMVUTTRA

Transthyretin amyloidosis

$67M Part D

Peak

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Data Sources

Drug label: DailyMed / FDA
Clinical trials: ClinicalTrials.gov
Patent data: FDA Orange Book
Spending data: CMS Medicare

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.

Pipeline & Clinical Trials

ATTR Prevalence and Prediction Study

Transthyretin Amyloidosis

N/A

TRAMmoniTTR TTR Screening and Monitoring Study

Transthyretin Amyloidosis

N/A

Patisiran Pregnancy Surveillance Program

Hereditary Transthyretin-mediated (hATTR) Amyloidosis

N/A

Patisiran ATTRv Effectiveness Study

Hereditary Transthyretin-mediated (ATTRv) Amyloidosis

N/A

99mTc-pyrophosphate Scintigraphy

Transthyretin Amyloidosis

N/A

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis

Transthyretin-Mediated Amyloidosis

N/A

Clinical Trials (1)

NCT04561518ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

N/A

ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)

Acute Hepatic Porphyria

N/A

Clinical Trials (1)

NCT04883905ELEVATE, a Registry of Patients With Acute Hepatic Porphyria (AHP)

N/A

INSIGHT-AHP Acute Hepatic Porphyria Prevalence Study

Acute Hepatic Porphyria

N/A

TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positiv

Transthyretin Amyloidosis

N/A

Clinical Trials (1)

NCT03237494TRAMmoniTTR Study Genetic Screening of an At-risk Population for hATTR and Monitoring of TTR Positive Subjects

N/A

DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Re

Transthyretin Amyloidosis With Cardiomyopathy

N/A

Clinical Trials (1)

NCT07358078DemonsTTRate: A Global, Observational, Multicenter, Long-term Study of Patients With ATTR-CM in a Real-World Setting

N/A

No intervention. Retrospective observation only.

Chronic Inflammatory Demyelinating Polyneuropathy

N/A

Clinical Trials (1)

NCT05940922RWE-based Treatment Patterns and Outcomes in CIDP

N/A

DISCOVERY Cardiac Amyloidosis Prevalence Study

Familial Amyloidotic Cardiomyopathy (FAC)

N/A

ALECT2 Disease Natural History Study

Leukocyte Chemotactic Factor 2 Amyloidosis

N/A

ConTTRibute ATTR Amyloidosis Registry

Transthyretin-Mediated Amyloidosis

N/A

TTR Amyloidosis Biomarker Study

Hereditary Amyloidosis, Transthyretin-Related

N/A

INSIGHT-AHP: A Study to Characterize the Prevalence of Acute Hepatic Porphyria (AHP) in Patients Wit

Acute Hepatic Porphyria

N/A

Clinical Trials (1)

NCT03547297INSIGHT-AHP: A Study to Characterize the Prevalence of Acute Hepatic Porphyria (AHP) in Patients With Clinical Presentation and History Consistent With AHP

N/A

EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)

Acute Hepatic Porphyria

N/A

Clinical Trials (1)

NCT02240784EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)

N/A

Natural History of Acute Hepatic Porphyria

Acute Hepatic Porphyria

N/A

A Study of the Natural History of Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) Disease

Amyloidosis

N/A

Clinical Trials (1)

NCT03774784A Study of the Natural History of Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) Disease

N/A

Standard of Care

Hereditary Amyloidosis, Transthyretin-Related

N/A

Clinical Trials (3)

NCT06272487Zilebesiran as Add-on Therapy in Patients With High Cardiovascular Risk and Hypertension Not Adequately Controlled by Standard of Care Antihypertensive Medications (KARDIA-3)

Phase 2

NCT05103332Zilebesiran as Add-on Therapy in Patients With Hypertension Not Adequately Controlled by a Standard of Care Antihypertensive Medication (KARDIA-2)

Givosiran (Acute Hepatic Porphyria registry)

Acute Hepatic Porphyria

N/A

BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)

Primary Hyperoxaluria Type 1

N/A

Clinical Trials (1)

NCT04982393BONAPH1DE, A Prospective Observational Study of Patients With Primary Hyperoxaluria Type 1 (PH1)

N/A

CIDP treatment patterns and outcomes

Chronic Inflammatory Demyelinating Polyneuropathy

N/A

ALN-GO1 (Primary Hyperoxaluria registry)

Primary Hyperoxaluria Type 1

N/A

DISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac

Familial Amyloidotic Cardiomyopathy (FAC)

N/A

Clinical Trials (1)

NCT02252653DISCOVERY: A Study Examining the Prevalence of TTR Mutations in Subjects Suspected of Having Cardiac Amyloidosis

N/A

DemonsTTRate ATTR-CM Registry

Transthyretin Amyloidosis With Cardiomyopathy

N/A

ALN-TTRSC04

Transthyretin-Mediated Amyloidosis

Phase 1

Clinical Trials (1)

NCT05661916A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ALN-TTRSC04 in Healthy Subjects

Phase 1

ALN-TTR02

TTR-mediated Amyloidosis

Phase 1

Clinical Trials (5)

NCT01960348APOLLO: The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis

Phase 3

NCT02510261The Study of an Investigational Drug, Patisiran (ALN-TTR02), for the Treatment of Transthyretin (TTR)-Mediated Amyloidosis in Participants Who Have Already Been Treated With ALN-TTR02 (Patisiran)

ALN-4915

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT07535606A Study to Evaluate ALN-4915 in Adult Healthy Volunteers

Phase 1

ALN-AGT01 RVR

Hypertension

Phase 1

ALN-PCSSC

Hypercholesterolemia

Phase 1

Clinical Trials (1)

NCT02314442A Phase 1 Study of an Investigational Drug, ALN-PCSSC, in Subjects With Elevated Low Density Lipoprotein Cholesterol (LDL-C)

Phase 1

ALN-HTT02

Huntington's Disease

Phase 1

Clinical Trials (1)

NCT06585449A Study to Evaluate ALN-HTT02 in Adult Patients With Huntington's Disease

Phase 1

ALN-BCAT

Advanced Hepatocellular Carcinoma

Phase 1

Clinical Trials (1)

NCT06600321A Study to Evaluate ALN-BCAT in Patients With Hepatocellular Carcinoma

Phase 1

ALN-5288

Alzheimer's Disease

Phase 1

Clinical Trials (1)

NCT07214727A Study to Evaluate ALN-5288 in Patients With Alzheimer's Disease

Phase 1

ALN-HBV

Chronic Hepatitis B

Phase 1

Clinical Trials (1)

NCT02826018A Study of ALN-HBV in Healthy Adult Volunteers and Non-cirrhotic Patients With Chronic Hepatitis B Virus (HBV) Infection

Phase 1

ATTR Algorithm Identification Study

Transthyretin Amyloidosis

Phase 1

Computer algorithm for ATTR

Transthyretin Amyloidosis

Phase 1

Clinical Trials (1)

NCT04569903Evaluation of a Claims-based Algorithm for the Identification of Transthyretin-mediated Amyloidosis (ATTR) Amyloidosis in Medical Records

Phase 1

ALN-TTRSC02

Transthyretin-mediated Amyloidosis (ATTR Amyloidosis)

Phase 1

Clinical Trials (1)

NCT02797847A Safety and Tolerability Study of an Investigational Drug, ALN-TTRSC02, in Healthy Subjects

Phase 1

ALN-HSD

Nonalcoholic Steatohepatitis (NASH)

Phase 1

Clinical Trials (1)

NCT04565717A Study of ALN-HSD in Healthy Adult Subjects and Adult Patients With Nonalcoholic Steatohepatitis (NASH)

Phase 1

ALN-PCS02

Elevated LDL-Cholesterol (LDL-C)

Phase 1

Clinical Trials (1)

NCT01437059Trial to Evaluate Safety and Tolerability of ALN-PCS02 in Subjects With Elevated LDL-Cholesterol (LDL-C)

Phase 1

ALN-4285

Healthy Volunteers

Phase 1

Clinical Trials (1)

NCT07295717A Study to Evaluate ALN-4285 in Adult Healthy Volunteers

Phase 1

ALN-AAT

Antitrypsin Deficiency Liver Disease

Phase 1

Clinical Trials (2)

NCT03767829A Study of ALN-AAT02 in Healthy Participants and Participants With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Phase 1/2

NCT02503683A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

ALN-VSP02

Solid Tumors

Phase 1

Clinical Trials (2)

NCT00882180Dose Escalation Trial to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Intravenous ALN-VSP02 In Patients With Advanced Solid Tumors With Liver Involvement

Phase 1

NCT01158079Multi-center, Open Label, Extension Study of ALN-VSP02 in Cancer Patients Who Have Responded to ALN-VSP02 Treatment

ALN-TTR01

Transthyretin Mediated Amyloidosis (ATTR)

Phase 1

Clinical Trials (1)

NCT01148953Trial to Evaluate Safety and Tolerability of ALN-TTR01 in Transthyretin (TTR) Amyloidosis

Phase 1

ALN-6222

Obesity

Phase 1

Clinical Trials (1)

NCT07624071A Study to Evaluate ALN-6222 in Participants With Obesity

Phase 1

ALN-6400

Hereditary Hemorrhagic Telangiectasia (HHT)

Phase 1/2

Clinical Trials (2)

NCT07575308HMBeacon: A Phase 2 Study to Evaluate ALN-6400 in Adult and Adolescent Female Patients With VWD and HMB

Phase 2

NCT06659640A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)

ALN-CC5

Paroxysmal Nocturnal Hemoglobinuria (PNH)

Phase 1/2

Clinical Trials (1)

NCT02352493A Phase 1/2 Study of an Investigational Drug, ALN-CC5, in Healthy Adult Volunteers and Patients With PNH

Phase 1/2

ALN-KHK

Type 2 Diabetes Mellitus (T2DM)

Phase 1/2

Clinical Trials (1)

NCT05761301A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM

Phase 1/2

ALN-2232

Obesity

Phase 1/2

Clinical Trials (1)

NCT07463846A Study to Evaluate ALN-2232 in Participants With Obesity

Phase 1/2

ALN-AAT02

ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease

Phase 1/2

Alnylam Pharmaceuticals(ALNY)

Should You Work at Alnylam Pharmaceuticals?

Why Work Here

Key Products

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Key Products by Revenue

Other Products (1)

Pipeline & Clinical Trials

Recent News · Alnylam Pharmaceuticals(10)

Open Jobs (10)

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Financials (FY2025)

Hiring Trend

Visa Sponsorship

Private Funding (SEC Form D)

Research Publications(10)