Mild Cognitive Impairment Due to Alzheimer's Disease

Neurology
5
Pipeline Programs
2
Companies
3
Clinical Trials
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
2
2
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

Takeda
ACTOSApproved
pioglitazone
Takeda
oral1999
U
PIOGLITAZONE HYDROCHLORIDEApproved
pioglitazone
Unknown Company
oral2013

Competitive Landscape

2 companies ranked by most advanced pipeline stage

Takeda
TakedaTOKYO, Japan
2 programs
2
1
PioglitazonePhase 31 trial
PioglitazonePhase 31 trial
Active Trials
NCT01931566Terminated3,494Est. Sep 2018
NCT02284906Terminated40Est. May 2018
Priavoid
PriavoidGermany - Düsseldorf
1 program
1
PRI-002Phase 21 trial
Active Trials
NCT06182085Active Not RecruitingEst. Apr 2026

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
TakedaPioglitazone
TakedaPioglitazone
PriavoidPRI-002

Clinical Trials (3)

Total enrollment: 3,534 patients across 3 trials

NCT02284906TakedaPioglitazone

AD-4833/TOMM40_303 Extension Study of the Safety and Efficacy of Pioglitazone to Slow Cognitive Decline in Participants With Mild Cognitive Impairment Due to Alzheimer Disease

Start: Feb 2015Est. completion: May 201840 patients
Phase 3Terminated
NCT01931566TakedaPioglitazone

Biomarker Qualification for Risk of Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease (AD) and Safety and Efficacy Evaluation of Pioglitazone in Delaying Its Onset

Start: Aug 2013Est. completion: Sep 20183,494 patients
Phase 3Terminated
NCT06182085PriavoidPRI-002

Study to Assess Safety and Efficacy of PRI-002 in Patients With MCI to Mild Dementia Due to Alzheimer's Disease (AD)

Start: Dec 2023Est. completion: Apr 2026
Phase 2Active Not Recruiting

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
2 companies competing in this space

Related Indications

Multiple Sclerosis(274)Schizophrenia(255)Epilepsy(242)Parkinson Disease(171)Alzheimer's Disease(165)Parkinson's Disease(160)Alzheimer Disease(117)Stroke(102)Relapsing-Remitting Multiple Sclerosis(83)Depression(82)