Meningitis

Infectious Diseases
4
Pipeline Programs
3
Companies
24
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Sanofi
SanofiPARIS, France
4 programs
1
1
Meningococcal polysaccharide diphtheria toxoid conjugatePhase 41 trial
Meningococcal Polysaccharide Diphtheria Toxoid ConjugatePhase 25 trials
Menactra®: Meningococcal Polysaccharide Diphtheria Toxoid ConjugateN/A1 trial
MeningococcalN/A5 trials
Active Trials
NCT01689155Completed116Est. Apr 2016
NCT02640404Completed224Est. Dec 2016
NCT02699840Completed100Est. Jul 2016
+9 more trials
Novartis
NovartisBASEL, Switzerland
2 programs
1
1
4CMenBPhase 41 trial
MeningococcalPhase 31 trial
Active Trials
NCT00901940Completed150Est. Oct 2010
NCT02080559Completed187Est. Apr 2018
Pfizer
PfizerNEW YORK, NY
1 program
Understanding Pneumococcal Carriage and DiseaseN/A2 trials
Active Trials
NCT03102840Unknown2,400Est. Oct 2020
NCT01996007Completed1,200Est. Aug 2015

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Novartis4CMenB
SanofiMeningococcal polysaccharide diphtheria toxoid conjugate
SanofiMeningococcal
SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate
SanofiMeningococcal
SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate
SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate
NovartisMeningococcal
SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate
SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate
SanofiMeningococcal
SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate
SanofiMeningococcal
SanofiMeningococcal
SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Showing 15 of 24 trials with date data

Clinical Trials (24)

Total enrollment: 12,092 patients across 24 trials

Investigating the Immune Response to 4CMenB in Infants

Start: Jul 2014Est. completion: Apr 2018187 patients
Phase 4Completed
NCT01659996SanofiMeningococcal polysaccharide diphtheria toxoid conjugate

Study of Menactra® in Healthy Subjects at 9 Months and Concomitantly With Pentacel® at 15 to 18 Months of Age

Start: Jul 2012Est. completion: Sep 20151,394 patients
Phase 4Completed
NCT01430611SanofiMeningococcal

Study of Sanofi Pasteur and Lanzhou Institute's Meningococcal (Group A and C) Polysaccharide Vaccine in Children

Start: Aug 2011Est. completion: Nov 2012666 patients
Phase 4Completed
NCT01270503SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Post-Marketing Safety Study of Menactra® in Healthy Children, Adolescents, and Adults in the Philippines

Start: Dec 2010Est. completion: Jul 2014538 patients
Phase 4Completed
NCT01890759SanofiMeningococcal

Immunogenicity and Safety of Menactra® Vaccine in Subjects Aged 9 to 23 Months in India and in the Russian Federation

Start: Jun 2013Est. completion: Apr 2016300 patients
Phase 3Completed
NCT01519713SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Study of a Single Dose of Meningococcal Polysaccharide Diphtheria Toxoid Conjugate Vaccine (SP284) in Japanese Subjects

Start: Jan 2012Est. completion: Dec 2012200 patients
Phase 3Completed
NCT01086969SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

A Study of Meningococcal Vaccine, Menactra® in Healthy Subjects in India

Start: Jun 2010Est. completion: Jun 2011300 patients
Phase 3Completed
NCT00901940NovartisMeningococcal

Understanding the Immune Response to Meningitis Vaccines

Start: Jun 2009Est. completion: Oct 2010150 patients
Phase 3Completed
NCT00539032SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Immunology and Safety of Menactra® in Children in Saudi Arabia

Start: Sep 2007Est. completion: Feb 2009238 patients
Phase 3Completed
NCT00483574SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Study of the Safety of Menactra® Vaccine When Administered With Other Pediatric Vaccines to Healthy Toddlers

Start: May 2007Est. completion: Apr 20091,378 patients
Phase 3Completed
NCT00444951SanofiMeningococcal

Immunogenicity and Safety of Menactra® Vaccine in Adolescents in Saudi Arabia

Start: Feb 2007Est. completion: Feb 2009450 patients
Phase 3Completed
NCT00384397SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

A Study of 2 Doses of Menactra®, a Meningococcal Conjugate Vaccine in Healthy Toddlers

Start: Sep 2006Est. completion: Feb 20091,128 patients
Phase 3Completed
NCT02640404SanofiMeningococcal

Safety of a Meningococcal (Groups A, C, Y and W-135) Polysaccharide Diphtheria Toxoid Conjugate Vaccine in Healthy Subjects in Vietnam

Start: Jun 2016Est. completion: Dec 2016224 patients
Phase 2Completed
NCT01187433SanofiMeningococcal

Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America

Start: Aug 2010Est. completion: Dec 2012150 patients
Phase 2Completed
NCT00700713SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Antibody Persistence and Booster Dose Response in Subjects Who Received Menactra® Three Years Earlier in Study MTA26

Start: Jun 2008Est. completion: Mar 2009181 patients
Phase 2Completed
NCT00269477SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Persistence of Antibodies in Adolescents and Adults 15 to 23 Years Who Received One Dose of Menactra® or Menomune®

Start: Dec 2005Est. completion: Dec 2007145 patients
Phase 2Completed
NCT00777790SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Study of a Booster Dose of Meningococcal Diphtheria Toxoid Conjugate Vaccine in Adolescents

Start: Feb 2004Est. completion: Apr 2005241 patients
Phase 2Completed
NCT00772629SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Antibody Responses Following Meningococcal Tetravalent (A, C, Y, and W-135) Conjugate Vaccination in Healthy Adults

Start: Jan 2004Est. completion: Apr 200418 patients
Phase 2Terminated
NCT00771849SanofiMeningococcal Polysaccharide Diphtheria Toxoid Conjugate

Study of Antibody Responses After a Dose of Tetravalent Meningococcal Diphtheria Conjugate Vaccine in Children

Start: Aug 2003Est. completion: May 2004103 patients
Phase 2Completed
NCT06165276SanofiMeningococcal

A Phase I, Randomized, Modified Single-blind, Active-controlled (Infants Only), Four-stage, Step-down, Comparative, Multi-center Study

Start: Jul 2006Est. completion: Aug 2008285 patients
Phase 1Completed
NCT03102840PfizerUnderstanding Pneumococcal Carriage and Disease

Understanding Pneumococcal Carriage and Disease 2017-2020

Start: Jun 2017Est. completion: Oct 20202,400 patients
N/AUnknown
NCT02699840SanofiMeningococcal

Observational Safety Study of Menactra® Administered Under Standard Health Care Practice in the Russian Federation

Start: Feb 2016Est. completion: Jul 2016100 patients
N/ACompleted
NCT01996007PfizerUnderstanding Pneumococcal Carriage and Disease

Understanding Pneumococcal Carriage and Disease

Start: Mar 2014Est. completion: Aug 20151,200 patients
N/ACompleted
NCT01689155SanofiMenactra®: Meningococcal Polysaccharide Diphtheria Toxoid Conjugate

Post-licensure Safety Surveillance Study of Menactra Vaccine When Administered As a 2-dose Schedule to Children

Start: Jun 2011Est. completion: Apr 2016116 patients
N/ACompleted

Related Jobs in Infectious Diseases

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
3 companies competing in this space