Liver Diseases

Gastroenterology
8
Pipeline Programs
7
Companies
12
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
6
0
2
0
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
2100%
+ 8 programs with unclassified modality

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
4 programs
3
1
AvenciguatPhase 21 trial
AfatinibPhase 1Small Molecule1 trial
BI 690517Phase 11 trial
ZongertinibPhase 1Small Molecule1 trial
Active Trials
NCT01298063Completed35
NCT05731908Completed28Est. Apr 2023
NCT06692322Completed29Est. Jun 2025
+1 more trials
Astellas
AstellasChina - Shenyang
1 program
1
ATGPhase 21 trial
Active Trials
NCT00436722Terminated72
Pfizer
PfizerNEW YORK, NY
2 programs
2
OsivelotorPhase 11 trial
PF-07923568Phase 13 trials
Active Trials
NCT06340347Completed8Est. Sep 2024
NCT06037031Completed16Est. Jul 2024
NCT06003829Completed12Est. Sep 2023
+1 more trials
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
1
EtavopivatPhase 11 trial
Active Trials
NCT06336018Completed48Est. Aug 2025
OrganOx
OrganOxUK - Oxford
1 program
Declined liver in Normothermic Machine PerfusionN/A1 trial
Active Trials
NCT04483102Active Not RecruitingEst. Dec 2025
Novartis
NovartisBASEL, Switzerland
1 program
Epidemiological Study in Children and Adolescents With Chronic Hepatitis BN/A1 trial
Active Trials
NCT01163240Completed1,640

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Boehringer IngelheimAvenciguat
AstellasATG
Boehringer IngelheimZongertinib
Novo NordiskEtavopivat
PfizerOsivelotor
PfizerPF-07923568
PfizerPF-07923568
PfizerPF-07923568
Boehringer IngelheimBI 690517
Boehringer IngelheimAfatinib
OrganOxDeclined liver in Normothermic Machine Perfusion
NovartisEpidemiological Study in Children and Adolescents With Chronic Hepatitis B

Clinical Trials (12)

Total enrollment: 2,006 patients across 12 trials

A Study to Test Whether BI 685509 Alone or in Combination With Empagliflozin Helps People With Liver Cirrhosis Caused by Viral Hepatitis or Non-alcoholic Steatohepatitis (NASH) Who Have High Blood Pressure in the Portal Vein (Main Vessel Going to the Liver)

Start: Jun 2022Est. completion: Jun 202490 patients
Phase 2Terminated

Induction Treatment Followed by Immunosuppression Withdrawal in Liver Transplantation: A Comparative Trial

Start: Jun 200672 patients
Phase 2Terminated

A Study to Test How Zongertinib is Taken up in the Blood of People With and Without Liver Problems

Start: Jan 2025Est. completion: Jun 202529 patients
Phase 1Completed

A Research Study on Etavopivat in Participants With and Without Liver Disease

Start: May 2024Est. completion: Aug 202548 patients
Phase 1Completed

A Study to Learn How the Body Processes the Study Medicine Called Osivelotor (PF-07940367) in People With Loss of Liver Function

Start: Apr 2024Est. completion: Sep 20248 patients
Phase 1Completed

A Study to Learn How the Body Processes the Study Medicine Called PF-07923568 in People With Loss of Kidney Function

Start: Oct 2023Est. completion: Jul 202416 patients
Phase 1Completed

A Study to Learn About the Tastes of Different Suspensions With the Study Medicine (PF-07923568) in Healthy Adult Participants.

Start: Jul 2023Est. completion: Sep 202312 patients
Phase 1Completed

A Study to Compare How the Study Medicine (PF-07923568) is Processed in Participants With Different Levels of Loss of Liver Function to Healthy Participants.

Start: Jun 2023Est. completion: Feb 202428 patients
Phase 1Completed

A Study to Test How BI 690517 is Taken up in the Body of People With and Without Liver Problems

Start: Feb 2023Est. completion: Apr 202328 patients
Phase 1Completed

Influence of Mild and Moderate Hepatic Impairment on the Pharmacokinetics, Safety and Tolerability of Various Doses of Afatinib

Start: Feb 201135 patients
Phase 1Completed
NCT04483102OrganOxDeclined liver in Normothermic Machine Perfusion

RESTORE Declined Livers Study

Start: Dec 2020Est. completion: Dec 2025
N/AActive Not Recruiting
NCT01163240NovartisEpidemiological Study in Children and Adolescents With Chronic Hepatitis B

Epidemiological Study in Children and Adolescents With Chronic Hepatitis B

Start: Jun 20091,640 patients
N/ACompleted

Related Jobs in Gastroenterology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

7 companies competing in this space