Liver Disease

Gastroenterology
5
Pipeline Programs
4
Companies
12
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
1
1
0
0
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

U
ERAXISApproved
anidulafungin
Unknown Company
Echinocandin Antifungal [EPC]intravenous2006

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
1 program
1
AnidulafunginPhase 45 trials
Active Trials
NCT01303549Completed61Est. May 2014
NCT01202253Completed50Est. May 2011
NCT00934934Terminated61Est. Aug 2012
+2 more trials
Lantheus Medical Imaging
1 program
1
Peflutren Lipid Microsphere Injectable SuspensionPhase 21 trial
Active Trials
NCT00162058CompletedEst. Apr 2006
Biogen
BiogenCAMBRIDGE, MA
1 program
1
RTA 402Phase 1/22 trials
Active Trials
NCT00535314Withdrawn0
NCT00550849Terminated16Est. Nov 2007
Astellas
AstellasChina - Shenyang
1 program
1
ASP1941Phase 11 trial
Active Trials
NCT01187186Completed16Est. Aug 2010

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
PfizerAnidulafungin
PfizerAnidulafungin
PfizerAnidulafungin
PfizerAnidulafungin
Lantheus Medical ImagingPeflutren Lipid Microsphere Injectable Suspension
PfizerAnidulafungin
PfizerAnidulafungin
BiogenRTA 402
PfizerAnidulafungin
AstellasASP1941
PfizerAnidulafungin

Clinical Trials (12)

Total enrollment: 421 patients across 12 trials

NCT01303549PfizerAnidulafungin

Anidulafungin vs Amphotericin B Safety in High Risk Hepatic Transplant Recipients

Start: Nov 2011Est. completion: May 201461 patients
Phase 4Completed
NCT00537329PfizerAnidulafungin

Anidulafungin In Treatment Of Candidemia In Asian Subjects

Start: Jan 2008Est. completion: Mar 200943 patients
Phase 3Completed
NCT00535314BiogenRTA 402

Study of Two Dose Levels of RTA 402 in Patients With Advanced Malignant Melanoma

0
Phase 2Withdrawn
NCT00934934PfizerAnidulafungin

Candida in the Respiratory Tract Secretions of Critically Ill Patients and The Efficacy of Antifungal Treatment

Start: Apr 2010Est. completion: Aug 201261 patients
Phase 2Terminated
NCT01053884PfizerAnidulafungin

Anidulafungin in Patients With Hematologic Malignancies

Start: Oct 2009Est. completion: Sep 201110 patients
Phase 2Terminated
NCT00162058Lantheus Medical ImagingPeflutren Lipid Microsphere Injectable Suspension

A Phase II Study of DMP 115 to Assess Focal Liver Lesions

Start: Mar 2004Est. completion: Apr 2006
Phase 2Completed
NCT00041704PfizerAnidulafungin

The Safety and Efficacy of Intravenous Anidulafungin as a Treatment for Azole-Refractory Mucosal Candidiasis (FRMC)

Start: Aug 2002Est. completion: Aug 200419 patients
Phase 2Completed
NCT00037219PfizerAnidulafungin

The Safety and Effectiveness of Intravenous Anidulafungin as a Treatment for Patients With Invasive Candidiasis.

Start: Aug 2001Est. completion: Nov 2002120 patients
Phase 2Completed
NCT00550849BiogenRTA 402

Study to Assess the Safety, Tolerability, and Pharmacodynamics of RTA 402 in Patients With Hepatic Dysfunction

Start: Apr 2007Est. completion: Nov 200716 patients
Phase 1/2Terminated
NCT00056381PfizerAnidulafungin

Safety, Tolerance and Pharmacokinetics of Anidulafungin in Immunocompromised Children Ages 2-17

Start: Jul 2003Est. completion: Jun 200425 patients
Phase 1/2Completed
NCT01187186AstellasASP1941

A Study to Assess the Effect of Hepatic Function on the Pharmacokinetics and Safety of ASP1941

Start: May 2010Est. completion: Aug 201016 patients
Phase 1Completed
NCT01202253PfizerAnidulafungin

Early Clinical Experience With Anidulafungin In Patients With Liver Disease In The United Kingdom

Start: Feb 2011Est. completion: May 201150 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 companies competing in this space

Related Indications

Hepatic Impairment(79)Gastroesophageal Reflux Disease(37)Irritable Bowel Syndrome(29)Gastroesophageal Reflux(27)Liver Transplantation(24)Celiac Disease(23)Hepatic Insufficiency(22)Liver Cirrhosis(22)Gastroesophageal Reflux Disease (GERD)(14)Hepatic Encephalopathy(12)