Ischemic Stroke

Neurology
16
Pipeline Programs
18
Companies
30
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
0
7
0
3
3
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

18 companies ranked by most advanced pipeline stage

Penumbra
PenumbraALAMEDA, CA
3 programs
1
intravenousPhase 41 trial
Mechanical thrombectomyN/A1 trial
Penumbra Aspiration SystemN/A1 trial
Active Trials
NCT04693767Completed400Est. Aug 2022
NCT02678169Completed204Est. Nov 2017
NCT01429350Completed108Est. Oct 2016
Pfizer
PfizerNEW YORK, NY
2 programs
1
Oral AnticoagulantPhase 41 trial
Target : 100 mg/dLN/A1 trial
Active Trials
NCT01252875Completed2,873Est. May 2019
NCT03062319Terminated321Est. Jul 2023
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
RepathaPhase 41 trial
Active Trials
NCT04573777Terminated10Est. Dec 2021
Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
3 programs
1
Intra-arterial TenecteplasePhase 31 trial
Reveal LINQTM- LNQ11 Internal Loop Recorder plus standard cardiac monitoringN/A1 trial
not applicableN/A
Active Trials
NCT02684825Completed317Est. May 2022
NCT07357987Not Yet Recruiting488Est. Dec 2027
Pierre Fabre
Pierre FabreFrance - Aignan
1 program
1
F2695Phase 31 trial
Active Trials
NCT01639014Completed532Est. Feb 2015
Takeda
TakedaTOKYO, Japan
1 program
1
Low-dose rtPAPhase 31 trial
Active Trials
NCT01422616Completed4,587Est. Aug 2018
Heidelberg Pharma
Heidelberg PharmaGermany - Ladenburg
5 programs
3
Cold crystalloid infusions, 0.9%NaCl or Ringer'sPhase 22 trials
RhinoChillPhase 21 trial
ZOLL Thermogard XPPhase 21 trial
ThrombectomyN/A1 trial
not applicableN/A2 trials
Active Trials
NCT02135926Terminated4Est. Feb 2017
NCT03157934Unknown12,000Est. Mar 2024
NCT02533960Completed3,832Est. Jun 2022
+4 more trials
Zoll
ZollCA - San Jose
3 programs
2
NormothermiaPhase 21 trial
ZOLL Thermogard XPPhase 2
Thermogard XP3N/A1 trial
Active Trials
NCT03804060CompletedEst. May 2024
NCT02411877WithdrawnEst. Nov 2017
Genentech
GenentechCA - Oceanside
2 programs
1
AlteplasePhase 21 trial
Mild and Rapidly Improving Stroke StudyN/A1 trial
Active Trials
NCT02072681Completed2,175Est. Jun 2021
NCT01183533Completed40Est. Jan 2014
DS
Daiichi SankyoChina - Shanghai
2 programs
1
Behavioral intensificationPhase 21 trial
not applicableN/A
Active Trials
NCT03024476Completed67Est. Dec 2017
Bristol Myers Squibb
2 programs
1
BMS-986141Phase 11 trial
not applicableN/A
Active Trials
NCT02922452Completed16Est. Nov 2016
CSL Behring
CSL BehringIL - Bradley
1 program
1
PrivigenPhase 11 trial
Active Trials
NCT01628055Withdrawn0Est. Sep 2013
Pulse Biosciences
Pulse BiosciencesCA - Hayward
1 program
1
Pulse TherapeuticsPhase 11 trial
Active Trials
NCT01519076TerminatedEst. Jul 2014
Magneto Thrombectomy Solutions
2 programs
Magneto MicrocatheterN/A1 trial
Magneto WireN/A1 trial
Active Trials
NCT04466033Completed4Est. Jul 2024
NCT03890380Terminated4Est. Oct 2019
Bayer
BayerLEVERKUSEN, Germany
2 programs
Reveal LINQTM- LNQ11 Internal Loop Recorder plus standard cardiac monitoringN/A
not applicableN/A1 trial
Active Trials
NCT02788409Completed2,234Est. May 2018
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
Myocardial Damage In Patients With Cerebral InfarctionN/A1 trial
Active Trials
NCT00306579Completed250Est. May 2005
M&
Merck & Co.RAHWAY, NJ
1 program
Target : 100 mg/dLN/A
MicroTransponder
MicroTransponderTX - Austin
1 program
Vivistim SystemN/A1 trial
Active Trials
NCT05691023Active Not Recruiting50Est. Dec 2028

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
AmgenRepatha
PfizerOral Anticoagulant
Penumbraintravenous
Boehringer IngelheimIntra-arterial Tenecteplase
Pierre FabreF2695
TakedaLow-dose rtPA
Daiichi SankyoBehavioral intensification
ZollNormothermia
Heidelberg PharmaZOLL Thermogard XP
Heidelberg PharmaCold crystalloid infusions, 0.9%NaCl or Ringer's
Heidelberg PharmaCold crystalloid infusions, 0.9%NaCl or Ringer's
Heidelberg PharmaRhinoChill
GenentechAlteplase
Bristol Myers SquibbBMS-986141
CSL BehringPrivigen

Showing 15 of 30 trials with date data

Clinical Trials (30)

Total enrollment: 30,636 patients across 30 trials

NCT04573777AmgenRepatha

Reducing Intracranial atheroSclErosis With Repatha

Start: Apr 2021Est. completion: Dec 202110 patients
Phase 4Terminated
NCT03062319PfizerOral Anticoagulant

Optimal Antithrombotic Therapy in Ischemic Stroke Patients with Non-Valvular Atrial Fibrillation and Atherothrombosis

Start: Apr 2017Est. completion: Jul 2023321 patients
Phase 4Terminated
NCT01429350Penumbraintravenous

Assess the Penumbra System in the Treatment of Acute Stroke

Start: May 2012Est. completion: Oct 2016108 patients
Phase 4Completed
NCT07357987Boehringer IngelheimIntra-arterial Tenecteplase

Intra-arterial Tenecteplase for Acute Medium Vessel Occlusion Stroke

Start: Jan 2026Est. completion: Dec 2027488 patients
Phase 3Not Yet Recruiting
NCT01639014Pierre FabreF2695

Effect of F2695 on Functional Recovery After Ischemic Stroke

Start: Jul 2012Est. completion: Feb 2015532 patients
Phase 3Completed
NCT01422616TakedaLow-dose rtPA

Enhanced Control of Hypertension and Thrombolysis Stroke Study (ENCHANTED)

Start: Mar 2012Est. completion: Aug 20184,587 patients
Phase 3Completed
NCT03024476Daiichi SankyoBehavioral intensification

Optimization of Blood Pressure Management After Acute Ischemic Stroke and Its Prognostic Significance

Start: Sep 2016Est. completion: Dec 201767 patients
Phase 2Completed
NCT02411877ZollNormothermia

REperfusion With Cooling in CerebraL Acute IscheMia II

Start: Feb 2016Est. completion: Nov 2017
Phase 2Withdrawn
NCT01665885Heidelberg PharmaZOLL Thermogard XP

Hypothermia in Acute Ischemic Stroke - Surface Versus Endovascular Cooling (HAIS-SE)

Start: Aug 2012Est. completion: Nov 201560 patients
Phase 2Unknown
NCT01584180Heidelberg PharmaCold crystalloid infusions, 0.9%NaCl or Ringer's

A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Brain.Pad (iCOOL 3)

Start: Jan 2012Est. completion: May 201220 patients
Phase 2Completed
NCT01584167Heidelberg PharmaCold crystalloid infusions, 0.9%NaCl or Ringer's

A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Flex.Pads (iCOOL 2)

Start: Jan 2012Est. completion: Dec 201320 patients
Phase 2Unknown
NCT01573117Heidelberg PharmaRhinoChill

A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. RhinoChill (iCOOL 1)

Start: Sep 201020 patients
Phase 2Completed
NCT01183533GenentechAlteplase

Safety of Intravenous Thrombolysis for Wake-up Stroke

Start: Jul 2010Est. completion: Jan 201440 patients
Phase 2Completed
NCT02922452Bristol Myers SquibbBMS-986141

A Study to Evaluate the Effect of Diltiazem on the Pharmacokinetics (PK) of BMS-986141 in Healthy Subjects

Start: Sep 2016Est. completion: Nov 201616 patients
Phase 1Completed
NCT01628055CSL BehringPrivigen

IVIG in Acute Ischemic Stroke: A Pilot Study

Start: Mar 2013Est. completion: Sep 20130
Phase 1Withdrawn
NCT01519076Pulse BiosciencesPulse Therapeutics

A Safety Evaluation of the Use of Magnetic-guided Iron Particles

Start: Jun 2012Est. completion: Jul 2014
Phase 1Terminated
NCT05691023MicroTransponderVivistim System

VNS-REHAB At-Home - Post-Market Study for Using the Vivistim System® at Home

Start: Jun 2023Est. completion: Dec 202850 patients
N/AActive Not Recruiting
NCT04693767PenumbraMechanical thrombectomy

Investigation of Clot in Ischemic Stroke and Hematoma Evacuation

Start: Feb 2021Est. completion: Aug 2022400 patients
N/ACompleted
NCT04466033Magneto Thrombectomy SolutionsMagneto Microcatheter

Evaluation of the Safety and Performance of Magneto Microcatheter

Start: Nov 2020Est. completion: Jul 20244 patients
N/ACompleted
NCT03804060ZollThermogard XP3

REperfusion With Cooling in CerebraL Acute IscheMia II

Start: May 2019Est. completion: May 2024
N/ACompleted
NCT03890380Magneto Thrombectomy SolutionsMagneto Wire

Safety and Performance Evaluation of the Magneto Wire

Start: Dec 2018Est. completion: Oct 20194 patients
N/ATerminated
NCT03157934Heidelberg Pharmanot applicable

Schlaganfallkonsortium Rhein-Neckar (Stroke Consortium Rhine-Neckar)

Start: Oct 2017Est. completion: Mar 202412,000 patients
N/AUnknown
NCT02788409Bayernot applicable

Incidence of Second Primary Malignancies in Castration-Resistant Prostate Cancer: An Observational Retrospective Cohort Study in the US

Start: May 2016Est. completion: May 20182,234 patients
N/ACompleted
NCT02678169PenumbraPenumbra Aspiration System

European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke

Start: Feb 2016Est. completion: Nov 2017204 patients
N/ACompleted
NCT02684825Boehringer IngelheimReveal LINQTM- LNQ11 Internal Loop Recorder plus standard cardiac monitoring

Detection of Silent Atrial Fibrillation aFter Ischemic StrOke

Start: Oct 2015Est. completion: May 2022317 patients
N/ACompleted
NCT02533960Heidelberg Pharmanot applicable

Registry of Acute Stroke Under Novel Oral Anticoagulants - Prime

Start: Jun 2015Est. completion: Jun 20223,832 patients
N/ACompleted
NCT02072681GenentechMild and Rapidly Improving Stroke Study

Mild and Rapidly Improving Stroke Study

Start: Mar 2015Est. completion: Jun 20212,175 patients
N/ACompleted
NCT02135926Heidelberg PharmaThrombectomy

Thrombectomy in Patients Ineligible for iv tPA

Start: Mar 2014Est. completion: Feb 20174 patients
N/ATerminated
NCT01252875PfizerTarget : 100 mg/dL

Treat Stroke to Target

Start: Mar 2010Est. completion: May 20192,873 patients
N/ACompleted
NCT00306579Novo NordiskMyocardial Damage In Patients With Cerebral Infarction

Myocardial Damage In Patients With Cerebral Infarction

Start: Aug 2003Est. completion: May 2005250 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs — potential near-term approvals
18 companies competing in this space

Related Indications

Multiple Sclerosis(274)Schizophrenia(255)Epilepsy(242)Parkinson Disease(171)Alzheimer's Disease(165)Parkinson's Disease(160)Alzheimer Disease(117)Stroke(102)Relapsing-Remitting Multiple Sclerosis(83)Depression(82)