Hepatitis C Infection

Infectious Diseases
5
Pipeline Programs
7
Companies
7
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
2
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
3100%
+ 4 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

M&
Merck & Co.RAHWAY, NJ
3 programs
1
1
Pegintron + RibaPhase 41 trial
Grazoprevir + ElbasvirPhase 3Small Molecule1 trial
P-IFN alfa 2aN/A1 trial
Active Trials
NCT02112630Withdrawn0Est. Feb 2015
NCT02105701Completed420Est. Jun 2015
NCT01683786Unknown60Est. Dec 2014
Biotest Pharmaceuticals
Biotest PharmaceuticalsGermany - Dreieich
1 program
1
Civacir® 10%Phase 31 trial
Active Trials
NCT01804829CompletedEst. Jun 2016
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
Glecaprevir/PibrentasvirPhase 2Small Molecule1 trial
Active Trials
NCT04042740Completed45Est. Aug 2023
Bristol Myers Squibb
1 program
1
EscitalopramPhase 11 trial
Active Trials
NCT02175602Completed41
Arrowhead Pharmaceuticals
1 program
BoceprevirN/ASmall Molecule1 trial
Active Trials
NCT01465516Terminated105Est. Dec 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Merck & Co.Pegintron + Riba
Merck & Co.Grazoprevir + Elbasvir
Biotest PharmaceuticalsCivacir® 10%
AbbVieGlecaprevir/Pibrentasvir
Bristol Myers SquibbEscitalopram
Merck & Co.P-IFN alfa 2a
Arrowhead PharmaceuticalsBoceprevir

Clinical Trials (7)

Total enrollment: 671 patients across 7 trials

NCT01683786Merck & Co.Pegintron + Riba

36 vs 48 Wks Peg-Intron Plus Ribavirin for HCV Patients Without Rapid Virologic Response But Without HCV RNA at wk 8

Start: Aug 2011Est. completion: Dec 201460 patients
Phase 4Unknown
NCT02105701Merck & Co.Grazoprevir + Elbasvir

Study of Efficacy and Safety of Grazoprevir (MK-5172) + Elbasvir (MK-8742) With or Without Ribavirin for Participants With Hepatitis C Genotype 1, 4, or 6 Infections Who Have Failed Prior Treatment With Pegylated Interferon + Ribavirin (MK-5172-068)

Start: Jun 2014Est. completion: Jun 2015420 patients
Phase 3Completed
NCT01804829Biotest PharmaceuticalsCivacir® 10%

Civacir® Polyclonal Immune Globulin (IgG) to Prevent Hepatitis C Virus (HCV) Recurrence in Liver Transplant Patients.

Start: Jun 2013Est. completion: Jun 2016
Phase 3Completed
NCT04042740AbbVieGlecaprevir/Pibrentasvir

Glecaprevir/Pibrentasvir Fixed-dose Combination Treatment for Acute Hepatitis C Virus Infection

Start: Nov 2019Est. completion: Aug 202345 patients
Phase 2Completed
NCT02175602Bristol Myers SquibbEscitalopram

Study of Drug Combination on Pharmacokinetics in Healthy Volunteers

Start: Jun 201441 patients
Phase 1Completed
NCT02112630Merck & Co.P-IFN alfa 2a

Boceprevir in End Stage Renal Disease (ESRD)

Start: May 2013Est. completion: Feb 20150
N/AWithdrawn
NCT01465516Arrowhead PharmaceuticalsBoceprevir

Treating Hispanic Patients Diagnosed With Hepatitis C Using Boceprevir

Start: Nov 2011Est. completion: Dec 2013105 patients
N/ATerminated

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs — potential near-term approvals
7 companies competing in this space

Related Indications

HIV Infections(449)COVID-19(223)Hepatitis C(191)Influenza(173)HIV(138)HIV-1-infection(115)Hepatitis C, Chronic(94)Chronic Hepatitis B(93)Chronic Hepatitis C(91)Covid19(79)