Hepatic Veno-Occlusive Disease

Gastroenterology
2
Pipeline Programs
1
Companies
3
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
0
1
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
2100%
+ 1 programs with unclassified modality

Competitive Landscape

1 companies ranked by most advanced pipeline stage

Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
3 programs
1
1
DefibrotidePhase 3Peptide1 trial
DefibrotidePhase 2/3Peptide1 trial
European VOD RegistryN/A1 trial
Active Trials
NCT03032016Completed176Est. Jul 2019
NCT00272948Completed360Est. Jul 2009
NCT00628498Completed1,206Est. Sep 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Jazz PharmaceuticalsDefibrotide
Jazz PharmaceuticalsDefibrotide
Jazz PharmaceuticalsEuropean VOD Registry

Clinical Trials (3)

Total enrollment: 1,742 patients across 3 trials

NCT00628498Jazz PharmaceuticalsDefibrotide

Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study

Start: Dec 2007Est. completion: Sep 20161,206 patients
Phase 3Completed
NCT00272948Jazz PharmaceuticalsDefibrotide

Pediatric Trial Investigating the Incidence & Outcome of Veno-Occlusive Disease With the Prophylactic Use of Defibrotide

Start: Dec 2005Est. completion: Jul 2009360 patients
Phase 2/3Completed
NCT03032016Jazz PharmaceuticalsEuropean VOD Registry

European VOD Registry

Start: Apr 2015Est. completion: Jul 2019176 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
Peptide is the dominant modality (100% of programs)
1 companies competing in this space

Related Indications

Hepatic Impairment(79)Gastroesophageal Reflux Disease(37)Irritable Bowel Syndrome(29)Gastroesophageal Reflux(27)Liver Transplantation(24)Celiac Disease(23)Hepatic Insufficiency(22)Liver Cirrhosis(22)Gastroesophageal Reflux Disease (GERD)(14)Hepatic Encephalopathy(12)