Dementia

Neurology
7
Pipeline Programs
18
Companies
19
Clinical Trials
1 recruiting
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
3
0
0
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

Boehringer Ingelheim
PRADAXAApproved
dabigatran etexilate
Boehringer Ingelheim
oral2021

Competitive Landscape

15 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
1 program
1
Dabigatran EtexilatePhase 41 trial
Active Trials
NCT03061006Completed101Est. Mar 2021
Aphios
AphiosMA - Woburn
1 program
1
APH-1105Phase 21 trial
Active Trials
NCT03806478UnknownEst. Dec 2024
E
EisaiChina - Liaoning
1 program
1
RasagilinePhase 2
Teva
TevaIsrael - Petach Tikva
1 program
1
RasagilinePhase 24 trials
Active Trials
NCT01497652Completed34Est. Mar 2015
NCT01382342Completed50Est. Feb 2014
NCT00977665Completed174Est. Oct 2011
+1 more trials
Abbott
AbbottABBOTT PARK, IL
1 program
1
DepakotePhase 11 trial
Active Trials
NCT00197834Unknown20
M&
Merck & Co.RAHWAY, NJ
1 program
1
MK3134Phase 11 trial
Active Trials
NCT01110616Completed25Est. Oct 2010
Harmony Biosciences
Harmony BiosciencesPLYMOUTH MEETING, PA
2 programs
Nature-based interventionN/A1 trial
SingingN/A1 trial
Active Trials
NCT06451978Active Not Recruiting48Est. Nov 2025
NCT06880237Not Yet RecruitingEst. Jul 2025
Providence Therapeutics
1 program
Care EcosystemN/A1 trial
Active Trials
NCT05669365CompletedEst. Aug 2025
AM-Pharma
AM-PharmaNetherlands - Utrecht
1 program
Dementia Care ManagementN/A1 trial
Active Trials
NCT04741932CompletedEst. Aug 2023
3T Biosciences
3T BiosciencesCA - South SF
1 program
Dynamic Light Scattering Ocular Measurement in the Detection of DementiaN/A1 trial
Active Trials
NCT06613971RecruitingEst. Apr 2028
Plus Therapeutics
1 program
Experimental armN/A1 trial
Active Trials
NCT07251088Not Yet RecruitingEst. Dec 2028
ME Therapeutics
ME TherapeuticsNEW YORK, NY
1 program
Feasibility study of music-based mobile appN/A1 trial
Active Trials
NCT06140342UnknownEst. Jan 2025
Alliance Pharmaceuticals
1 program
Microcannula Harvest AdiposeN/A2 trials
Active Trials
NCT03297177Unknown300Est. Jan 2023
NCT02939859Withdrawn0Est. Oct 2023
Verona Pharma
Verona PharmaUK - London
1 program
Remote Cognitive Multidomain Assessment in People With Cognitive DisordersN/A1 trial
Active Trials
NCT06078332Completed114Est. Dec 2023
Sanofi
SanofiPARIS, France
1 program
Zolpidem CRN/A1 trial
Active Trials
NCT00814502Completed20Est. Dec 2013

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Boehringer IngelheimDabigatran Etexilate
TevaRasagiline
TevaRasagiline
AphiosAPH-1105
TevaRasagiline
TevaRasagiline
Alliance PharmaceuticalsMicrocannula Harvest Adipose
Merck & Co.MK3134
AbbottDepakote
Plus TherapeuticsExperimental arm
Harmony BiosciencesSinging
Harmony BiosciencesNature-based intervention
3T BiosciencesDynamic Light Scattering Ocular Measurement in the Detection of Dementia
ME TherapeuticsFeasibility study of music-based mobile app
Providence TherapeuticsCare Ecosystem

Showing 15 of 19 trials with date data

Clinical Trials (19)

Total enrollment: 1,262 patients across 19 trials

NCT03061006Boehringer IngelheimDabigatran Etexilate

Impact of Anticoagulation Therapy on the Cognitive Decline and Dementia in Patients With Non-Valvular Atrial Fibrillation

Start: Apr 2017Est. completion: Mar 2021101 patients
Phase 4Completed
NCT01497652TevaRasagiline

A Double Blind Placebo Controlled Trial Evaluating Rasagiline Effects on Cognition in Parkinson's Disease Patients With Mild Cognitive Impairment Receiving Dopaminergic Therapy

Start: Jan 2012Est. completion: Mar 201534 patients
Phase 4Completed
NCT01382342TevaRasagiline

The Effect of Rasagiline on Cognition in Parkinson's Disease

Start: Jun 2011Est. completion: Feb 201450 patients
Phase 4Completed
NCT03806478AphiosAPH-1105

Study of APH-1105 in Patients With Mild to Moderate Alzheimer's Disease

Start: Jun 2023Est. completion: Dec 2024
Phase 2Unknown
NCT00977665TevaRasagiline

Clinical Trial to Assess Efficacy, Safety, and Tolerability of Rasagiline Mesylate 1 mg in Patients With Multiple System Atrophy of the Parkinsonian Subtype (MSA-P)

Start: Dec 2009Est. completion: Oct 2011174 patients
Phase 2Completed
NCT00104273TevaRasagiline

Rasagiline 1 mg and 2 mg Added to Aricept 10 mg Daily in Patients With Mild to Moderate Alzheimer's Disease (AD)

Start: Aug 2004376 patients
Phase 2Completed
NCT02939859Alliance PharmaceuticalsMicrocannula Harvest Adipose

Use of Cellular Stromal Vascular Fraction in Multiple Sclerosis,Autoimmune, Inflammatory, Neurologic Conditions

Start: Dec 2018Est. completion: Oct 20230
Phase 1Withdrawn
NCT01110616Merck & Co.MK3134

EEG (Electroencephalogram) Platform Standardization in Healthy Male Subjects (3134-010)

Start: Jun 2010Est. completion: Oct 201025 patients
Phase 1Completed
NCT00197834AbbottDepakote

Study of Depakote for Behavioral and Psychological Symptoms in Dementia

Start: Mar 200420 patients
Phase 1Unknown
NCT07251088Plus TherapeuticsExperimental arm

Dyadic, App-supported Collaborative Care Intervention Trial for Family Caregivers of People Living With Dementia

Start: Jan 2026Est. completion: Dec 2028
N/ANot Yet Recruiting
NCT06880237Harmony BiosciencesSinging

Sing Out Loud: a Choral Singing Program for Persons Living with Dementia

Start: Mar 2025Est. completion: Jul 2025
N/ANot Yet Recruiting
NCT06451978Harmony BiosciencesNature-based intervention

You, Me and Nature Pilot Study

Start: Jan 2025Est. completion: Nov 202548 patients
N/AActive Not Recruiting
NCT066139713T BiosciencesDynamic Light Scattering Ocular Measurement in the Detection of Dementia

Dynamic Light Scattering Ocular Measurement in the Detection of Dementia

Start: Apr 2024Est. completion: Apr 2028
N/ARecruiting
NCT06140342ME TherapeuticsFeasibility study of music-based mobile app

A Music-Based Mobile App for People Living With Alzheimer's Disease and Related Dementias (ADRD)

Start: Aug 2023Est. completion: Jan 2025
N/AUnknown
NCT05669365Providence TherapeuticsCare Ecosystem

The Care Ecosystem Consortium Effectiveness Study

Start: Jan 2023Est. completion: Aug 2025
N/ACompleted
NCT06078332Verona PharmaRemote Cognitive Multidomain Assessment in People With Cognitive Disorders

Remote Cognitive Multidomain Assessment in People With Cognitive Disorders

Start: Dec 2021Est. completion: Dec 2023114 patients
N/ACompleted
NCT04741932AM-PharmaDementia Care Management

Interprofessional Dementia Care

Start: Jan 2021Est. completion: Aug 2023
N/ACompleted
NCT03297177Alliance PharmaceuticalsMicrocannula Harvest Adipose

Autologous Stem/Stromal Cells in Neurological Disorders and Disease

Start: Jan 2020Est. completion: Jan 2023300 patients
N/AUnknown
NCT00814502SanofiZolpidem CR

Zolpidem CR and Hospitalized Patients With Dementia

Start: Dec 2008Est. completion: Dec 201320 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 actively recruiting trials targeting 1,262 patients
18 companies competing in this space

Related Indications

Multiple Sclerosis(274)Schizophrenia(255)Epilepsy(242)Parkinson Disease(171)Alzheimer's Disease(165)Parkinson's Disease(160)Alzheimer Disease(117)Stroke(102)Relapsing-Remitting Multiple Sclerosis(83)Depression(82)