COVID

Infectious Diseases
7
Pipeline Programs
7
Companies
9
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
1
1
1
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
150%
Monoclonal Antibody
150%
+ 7 programs with unclassified modality

Competitive Landscape

7 companies ranked by most advanced pipeline stage

Kiniksa Pharmaceuticals
1 program
1
mavrilimumabPhase 2/3Monoclonal Antibody1 trial
Active Trials
NCT04447469Completed814Est. Jan 2022
ProgenaBiome
ProgenaBiomeCA - Ventura
3 programs
2
1
hydroxychloroquinePhase 21 trial
IvermectinPhase 11 trial
ResCure™Phase 11 trial
Active Trials
NCT04482686CompletedEst. Jul 2022
NCT04395716WithdrawnEst. Nov 2021
NCT04459702WithdrawnEst. Dec 2021
Apellis Pharmaceuticals
Apellis PharmaceuticalsAustralia - Hawthorn East
1 program
1
APL-9Phase 1/21 trial
Active Trials
NCT04402060Completed72Est. Feb 2021
ImmunityBio
ImmunityBioSAN DIEGO, CA
1 program
1
BM-Allo.MSCPhase 11 trial
Active Trials
NCT04397796Terminated4Est. Sep 2020
Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
1 program
1
DefibrotidePhase 1Peptide1 trial
Active Trials
NCT04530604Completed13Est. Apr 2021
AstraZeneca
AstraZenecaCAMBRIDGE, United Kingdom
1 program
Covid-19 Data Analyses in BrazilN/A1 trial
Active Trials
NCT06652451Completed361,000Est. Nov 2024
RS Medical
RS MedicalWA - Vancouver
1 program
Pediatric Acute and Critical Care COVID-19 Registry of AsiaN/A1 trial
Active Trials
NCT04395781Completed1,756Est. Mar 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Kiniksa Pharmaceuticalsmavrilimumab
ProgenaBiomehydroxychloroquine
Apellis PharmaceuticalsAPL-9
ProgenaBiomeIvermectin
Jazz PharmaceuticalsDefibrotide
ImmunityBioBM-Allo.MSC
ProgenaBiomeResCure™
AstraZenecaCovid-19 Data Analyses in Brazil
RS MedicalPediatric Acute and Critical Care COVID-19 Registry of Asia

Clinical Trials (9)

Total enrollment: 363,659 patients across 9 trials

NCT04447469Kiniksa Pharmaceuticalsmavrilimumab

Study of Mavrilimumab (KPL-301) in Participants Hospitalized With Severe Corona Virus Disease 2019 (COVID-19) Pneumonia and Hyper-inflammation

Start: Jul 2020Est. completion: Jan 2022814 patients
Phase 2/3Completed
NCT04459702ProgenaBiomehydroxychloroquine

A Study of Combination Therapies to Treat COVID-19 Infection

Start: Jul 2020Est. completion: Dec 2021
Phase 2Withdrawn
NCT04402060Apellis PharmaceuticalsAPL-9

A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19

Start: May 2020Est. completion: Feb 202172 patients
Phase 1/2Completed
NCT04482686ProgenaBiomeIvermectin

Trial of Combination Therapy to Treat COVID-19 Infection

Start: Dec 2020Est. completion: Jul 2022
Phase 1Completed
NCT04530604Jazz PharmaceuticalsDefibrotide

Defibrotide Therapy for SARS-CoV2 (COVID-19) Acute Respiratory Distress Syndrome (ARDS)

Start: Oct 2020Est. completion: Apr 202113 patients
Phase 1Completed
NCT04397796ImmunityBioBM-Allo.MSC

Study of the Safety of Therapeutic Tx With Immunomodulatory MSC in Adults With COVID-19 Infection Requiring Mechanical Ventilation

Start: Aug 2020Est. completion: Sep 20204 patients
Phase 1Terminated
NCT04395716ProgenaBiomeResCure™

A Study of ResCure™ to Treat COVID-19 Infection

Start: Jan 2020Est. completion: Nov 2021
Phase 1Withdrawn
NCT06652451AstraZenecaCovid-19 Data Analyses in Brazil

Covid-19 Data Analyses in Brazil

Start: Nov 2024Est. completion: Nov 2024361,000 patients
N/ACompleted
NCT04395781RS MedicalPediatric Acute and Critical Care COVID-19 Registry of Asia

Pediatric Acute and Critical Care COVID-19 Registry of Asia

Start: May 2020Est. completion: Mar 20231,756 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

7 companies competing in this space

Related Indications

HIV Infections(576)Influenza(314)COVID-19(229)Hepatitis C(201)HIV(178)Hepatitis B(148)HIV-1-infection(137)HIV Infection(108)Chronic Hepatitis B(103)Hepatitis C, Chronic(96)