Coronavirus Disease 2019 (COVID-19)

Infectious Diseases
6
Pipeline Programs
5
Companies
8
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
3
1
0
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
1100%
+ 7 programs with unclassified modality

Competitive Landscape

5 companies ranked by most advanced pipeline stage

Jazz Pharmaceuticals
Jazz PharmaceuticalsCA - Palo Alto
1 program
1
Dociparstat sodiumPhase 2/31 trial
Active Trials
NCT04389840Terminated27Est. May 2021
CSL Behring
CSL BehringIL - Bradley
3 programs
1
2
CSL324Phase 21 trial
Garadacimab, Factor XIIa Antagonist Monoclonal AntibodyPhase 21 trial
CSL760Phase 11 trial
Active Trials
NCT04638634Terminated12Est. Jun 2021
NCT04519424Withdrawn0Est. May 2021
NCT04409509Completed124Est. Jan 2021
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
2 programs
1
anti-CD14Phase 21 trial
Collection of Biological SamplesN/A1 trial
Active Trials
NCT04375761CompletedEst. Mar 2021
NCT04391309TerminatedEst. Feb 2022
Akesobio
AkesobioChina - Zhongshan
1 program
1
AK119Phase 11 trial
Active Trials
NCT04516564Completed29Est. Jun 2021
Pfizer
PfizerNEW YORK, NY
1 program
Nirmatrelvir/RitonavirN/ASmall Molecule1 trial
Active Trials
NCT07089680Not Yet Recruiting1,200Est. Nov 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Jazz PharmaceuticalsDociparstat sodium
Allergy Therapeuticsanti-CD14
CSL BehringCSL324
CSL BehringGaradacimab, Factor XIIa Antagonist Monoclonal Antibody
CSL BehringCSL760
AkesobioAK119
PfizerNirmatrelvir/Ritonavir
Allergy TherapeuticsCollection of Biological Samples

Clinical Trials (8)

Total enrollment: 1,392 patients across 8 trials

NCT04389840Jazz PharmaceuticalsDociparstat sodium

Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure

Start: Jul 2020Est. completion: May 202127 patients
Phase 2/3Terminated
NCT04391309Allergy Therapeuticsanti-CD14

COVID-19 and Anti-CD14 Treatment Trial

Start: Apr 2021Est. completion: Feb 2022
Phase 2Terminated
NCT04519424CSL BehringCSL324

CSL324 in COVID-19

Start: Sep 2020Est. completion: May 20210
Phase 2Withdrawn
NCT04409509CSL BehringGaradacimab, Factor XIIa Antagonist Monoclonal Antibody

Treatment With CSL312 in Adults With Coronavirus Disease 2019 (COVID-19)

Start: Jul 2020Est. completion: Jan 2021124 patients
Phase 2Completed
NCT04638634CSL BehringCSL760

Pharmacokinetics, Safety, and Tolerability of CSL760, an Intravenous Anti-SARS-CoV-2 Hyperimmune Globulin, in Healthy Adult Subjects

Start: Feb 2021Est. completion: Jun 202112 patients
Phase 1Terminated
NCT04516564AkesobioAK119

A Study of AK119 (Anti-CD73 Antibody), a Treatment for COVID-19, in Healthy Subjects

Start: Sep 2020Est. completion: Jun 202129 patients
Phase 1Completed
NCT07089680PfizerNirmatrelvir/Ritonavir

A Study to Learn About the Study Medicine Paxlovid (Nirmatrelvir + Ritonavir) in Adults Aged 60 and Older Living in Korean Long-term Care Hospitals Who Have COVID-19

Start: Aug 2025Est. completion: Nov 20251,200 patients
N/ANot Yet Recruiting
NCT04375761Allergy TherapeuticsCollection of Biological Samples

COVID-19: Human Epidemiology and Response to SARS-CoV-2

Start: May 2020Est. completion: Mar 2021
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

5 companies competing in this space

Related Indications

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