Chronic Plaque Psoriasis

Immunology
21
Pipeline Programs
8
Companies
50
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
7
0
10
4
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
11100%
+ 12 programs with unclassified modality

On Market (1)

Approved therapies currently available

UP
BIMZELXApproved
bimekizumab
UCB Pharma
injection2023

Competitive Landscape

8 companies ranked by most advanced pipeline stage

UP
UCB PharmaBelgium - Brussels
11 programs
5
6
1
BimekizumabPhase 3Monoclonal Antibody1 trial
BimekizumabPhase 3Monoclonal Antibody1 trial
BimekizumabPhase 3Monoclonal Antibody1 trial
BimekizumabPhase 3Monoclonal Antibody1 trial
BimekizumabPhase 3Monoclonal Antibody1 trial
+6 more programs
Active Trials
NCT03230292Completed43Est. Mar 2019
NCT03025542Completed49Est. Dec 2017
NCT02905006Completed250Est. Jul 2017
+8 more trials
Biogen
BiogenCAMBRIDGE, MA
5 programs
3
1
AlefaceptPhase 41 trial
AlefaceptPhase 31 trial
alefaceptPhase 3
alefaceptPhase 3
AlefaceptN/A1 trial
Active Trials
NCT00422617Completed40Est. Nov 2005
NCT00233662Completed400Est. Dec 2005
NCT00794807Completed20Est. Dec 2005
M&
Merck & Co.RAHWAY, NJ
1 program
1
EfalizumabPhase 4Monoclonal Antibody1 trial
Active Trials
NCT00972543Terminated6
Verona Pharma
Verona PharmaUK - London
1 program
1
efalizumab plus placeboPhase 41 trial
Active Trials
NCT00707070Unknown100Est. Oct 2009
Astellas
AstellasChina - Shenyang
2 programs
1
alefaceptPhase 31 trial
Amevive exposureN/A2 trials
Active Trials
NCT00795353Terminated64Est. Jan 2011
NCT00342862Terminated3Est. Dec 2011
NCT00673556Completed195Est. May 2005
Novartis
NovartisBASEL, Switzerland
1 program
1
AIN457Phase 25 trials
Active Trials
NCT05583604Available
NCT05569174Completed62Est. Dec 2024
NCT04711902Completed41Est. Mar 2023
+2 more trials
E
EisaiChina - Liaoning
1 program
1
E6201 0.005%Phase 21 trial
Active Trials
NCT00539929Completed100Est. Jul 2008
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
Chronic Plaque Psoriasis (Ps) RegistryN/A1 trial
Active Trials
NCT00799877Completed6,065Est. Feb 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
NovartisAIN457
NovartisAIN457
Verona Pharmaefalizumab plus placebo
Merck & Co.Efalizumab
BiogenAlefacept
NovartisAIN457
NovartisAIN457
UCB PharmaBimekizumab
UCB PharmaBimekizumab
UCB PharmaBimekizumab
UCB PharmaBimekizumab
UCB PharmaBimekizumab
UCB PharmaBimekizumab
NovartisAIN457
NovartisAIN457

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 15,024 patients across 50 trials

Study to Examine the Clinical Efficacy and the Nonsteroidal Anti-inflammatory Drug (NSAID)-Sparing Effect of Secukinumab Over 16 Weeks in Patients With Ankylosing Spondylitis

Start: May 2016Est. completion: Sep 2019211 patients
Phase 4Completed

Open-label Study of Subcutaneous Secukinumab to Evaluate Efficacy and Safety in Patients With Plaque Psoriasis Who Had Inadequate Response to Cyclosporine A

Start: Jun 2015Est. completion: May 201634 patients
Phase 4Completed
NCT00707070Verona Pharmaefalizumab plus placebo

Combining Acitretin and Efalizumab in the Therapy of Chronic Plaque Psoriasis

Start: Sep 2008Est. completion: Oct 2009100 patients
Phase 4Unknown

Raptiva in Palm and Sole Psoriasis

Start: Sep 20086 patients
Phase 4Terminated

Safety and Tolerability of Repeat Courses of IM Alefacept

Start: Feb 2004Est. completion: Dec 200520 patients
Phase 4Completed

Study of Efficacy and Safety of AIN457/Secukinumab in Patients With Rotator Cuff Tendinopathy

Start: Dec 2022Est. completion: Dec 202462 patients
Phase 3Completed

Study of Efficacy and Safety of Secukinumab in Chinese Subjects With Active PsA Compared to Placebo.

Start: Jun 2021Est. completion: Mar 202341 patients
Phase 3Completed

A Study to Evaluate the Safe and Effective Use of the Prefilled Safety Syringe or the Auto-injector for the Subcutaneous Self-injection of Bimekizumab Solution by Subjects With Moderate to Severe Chronic Plaque Psoriasis (PSO)

Start: Dec 2018Est. completion: Sep 2020172 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis

Start: Sep 2018Est. completion: Nov 20231,353 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to an Active Comparator in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis

Start: Jun 2018Est. completion: Aug 2023743 patients
Phase 3Completed

A Study With a Initial Treatment Period Followed by a Randomized-withdrawal Period to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis

Start: Feb 2018Est. completion: Jan 2020435 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis

Start: Jan 2018Est. completion: Feb 2020478 patients
Phase 3Completed

A Study to Evaluate the Efficacy and Safety of Bimekizumab Compared to Placebo and an Active Comparator in Adult Subjects With Moderate to Severe Chronic Plaque Psoriasis

Start: Dec 2017Est. completion: Dec 2019567 patients
Phase 3Completed

Effect of Secukinumab on Radiographic Progression in Ankylosing Spondylitis as Compared to GP2017 (Adalimumab Biosimilar)

Start: Nov 2017Est. completion: Nov 2021859 patients
Phase 3Completed

SKIPPAIN - Speed of Onset of SecuKinumab-Induced Relief From Pain in Patients With AxIal SpoNdyloarthritis

Start: Jun 2017Est. completion: Feb 2019383 patients
Phase 3Completed

An Extention Study of Safety of Canakinumab in Japanese Patients With Periodic Fever Syndromes

Start: Oct 2016Est. completion: Jan 20174 patients
Phase 3Completed

Study of Power Doppler Ultrasound (PDUS) to Measure Response of Secukinumab Treatment in Patients With Active Psoriatic Arthritis (PsA)

Start: Aug 2016Est. completion: Nov 2020166 patients
Phase 3Completed

Efficacy of Secukinumab Compared to Ustekinumab in Patients With Plaque-type Psoriasis

Start: Feb 2014Est. completion: Jun 2016676 patients
Phase 3Completed

Secukinumab in Tumor Necrosis Factor (TNF) - Inadequate Response (IR) Psoriasis Participants.

Start: Oct 2013Est. completion: Jul 2016235 patients
Phase 3Completed

Efficacy at 24 Weeks With Long Term Safety, Tolerability and Efficacy up to 5 Years of Secukinumab in Patients of Active Psoriatic Arthritis

Start: Apr 2013Est. completion: Jan 2019397 patients
Phase 3Completed

Secukinumab Efficacy and Safety Study in Patients With Rheumatoid Arthritis and Inadequate Response to Anti-TNFα Agents.

Start: Oct 2012Est. completion: May 2015242 patients
Phase 3Terminated

4 Year Extension Study of Efficacy and Safety of Secukinumab in Patients With Moderate to Severe Chronic Plaque-type Psoriasis

Start: Sep 2012Est. completion: May 2017675 patients
Phase 3Completed

Extension Study of Secukinumab Prefilled Syringes in Subjects With Moderate to Severe Chronic Plaque-type Psoriasis Completing Preceding Psoriasis Phase III Studies With Secukinumab

Start: Jun 2012Est. completion: Jun 20171,147 patients
Phase 3Completed

Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis (RA) and an Inadequate Response to Anti-Tumor Necrosis Factor α (Anti-TNFα) Agents (CAIN457F2309 and CAIN457F2309E1)

Start: Sep 2011Est. completion: Feb 2015551 patients
Phase 3Completed

Efficacy at 24 Weeks and Safety, Tolerability and Long Term Efficacy up to 2 Years of Secukinumab (AIN457) in Patients With Active Rheumatoid Arthritis and an Inadequate Response to Anti-TNFα Agents

Start: Aug 2011Est. completion: Sep 2015637 patients
Phase 3Completed

Efficacy and Safety of Subcutaneous Secukinumab (AIN457) for Moderate to Severe Chronic Plaque-type Psoriasis Assessing Different Doses and Dose Regimens

Start: Aug 2011Est. completion: May 2013967 patients
Phase 3Completed

Safety and Efficacy of Secukinumab Compared to Etanercept in Subjects With Moderate to Severe, Chronic Plaque-Type Psoriasis

Start: Jun 2011Est. completion: Jul 20131,306 patients
Phase 3Completed

Study to Evaluate the Long Term Use of Treatment With AIN457 for Uveitis

Start: Mar 20110
Phase 3Withdrawn

Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis

Start: Aug 2010Est. completion: Jul 201186 patients
Phase 3Terminated

Safety and Efficacy of AIN457 in Patients With Active Non-infectious Uveitis

Start: Apr 2010Est. completion: Oct 201030 patients
Phase 3Terminated

38 Week Extension Study to CAIN457C2303

Start: Mar 2010Est. completion: Jan 201159 patients
Phase 3Terminated

Safety and Efficacy of AIN457 in Patients With Quiescent Non-infectious Uveitis

Start: Feb 2010Est. completion: Jun 2011125 patients
Phase 3Terminated

Phase III Study in Refractory Behcet's Disease

Start: Oct 2009Est. completion: Jul 2010118 patients
Phase 3Completed

A Study to Assess the Efficacy and Safety of Alefacept in Psoriasis Patients for Whom Conventional Treatment is Ineffective or Inappropriate

Start: Oct 2003Est. completion: May 2005195 patients
Phase 3Completed

Safety and Tolerability of Repeat Courses of IM Alefacept

Start: Dec 2002Est. completion: Dec 2005400 patients
Phase 3Completed

Study of Efficacy, Safety and Tolerability of AIN457 in Patients With Active Overuse Tendinopathy

Start: Dec 2017Est. completion: Oct 201996 patients
Phase 2Completed

A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Adult Patients With Chronic Plaque Psoriasis

Start: Jul 2017Est. completion: Mar 201943 patients
Phase 2Completed

A Study to Evaluate the Pharmacokinetics (PK), Pharmacodynamics (PD), and Safety of Bimekizumab in Patients With Chronic Plaque Psoriasis

Start: Dec 2016Est. completion: Dec 201749 patients
Phase 2Completed

A Study to Evaluate the Long-term Safety, Tolerability and Efficacy of Bimekizumab in Patients With Chronic Plaque Psoriasis

Start: Dec 2016Est. completion: Sep 2018217 patients
Phase 2Completed

Study to Evaluate Safety and Efficacy of Different Doses of Bimekizumab in Patients With Chronic Plaque Psoriasis

Start: Aug 2016Est. completion: Jul 2017250 patients
Phase 2Completed

Efficacy and Safety of AIN457 (Secukinumab) in Patients With Relapsing Multiple Sclerosis

Start: Jun 2013Est. completion: Apr 201428 patients
Phase 2Terminated

Safety, Tolerability, and Efficacy of AIN457 in Patients With Uncontrolled Asthma

Start: Mar 2012Est. completion: Nov 201446 patients
Phase 2Terminated

A Study to Evaluate the Safety, Tolerability and Efficacy of AIN457 in Patients With Relapsing-remitting Multiple Sclerosis

Start: Feb 2012Est. completion: Jun 201439 patients
Phase 2Completed

Efficacy, Safety and Tolerability of Secukinumab in Patients With Rheumatoid Arthritis Taking Methotrexate

Start: Oct 2011Est. completion: Dec 2013221 patients
Phase 2Completed

A 3-arm Proof of Concept Study of AIN457, ACZ885 or Corticosteroids in Patients With Polymyalgia Rheumatica

Start: Feb 2011Est. completion: Jan 201316 patients
Phase 2Terminated

The Effects of a Single Intravenous Administration of Secukinumab (AIN457) or Canakinumab (ACZ885) in Dry Eye Patients

Start: Nov 2010Est. completion: Sep 201172 patients
Phase 2Completed

Safety and Tolerability of AIN457 in Adults (18-65 Years) With Psoriatic Arthritis

Start: Jun 2010Est. completion: Nov 201228 patients
Phase 2Completed

AIN457 Regimen Finding Extension Study in Participants With Moderate to Severe Psoriasis

Start: May 2010Est. completion: Oct 2016275 patients
Phase 2Completed

Safety and Tolerability of AIN457 in Adults (18-65 Years) With Moderate to Severe Ankylosing Spondylitis

Start: Apr 2010Est. completion: Dec 201239 patients
Phase 2Completed

A Dose Ranging Study of AIN457 in Patients With Moderate to Severe Chronic Plaque-type Psoriasis

Start: Mar 2010Est. completion: Feb 2011125 patients
Phase 2Completed

Related Jobs in Immunology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

10 late-stage (Phase 3) programs — potential near-term approvals
8 companies competing in this space