Chronic Myeloid Leukemia (CML)
Oncology
2
Pipeline Programs
3
Companies
4
Clinical Trials
2 recruiting
0
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
0
0
Early DiscoveryClinical DevelopmentMarket
Drug Modality Breakdown
Small Molecule
2100%
+ 2 programs with unclassified modality
Competitive Landscape
3 companies ranked by most advanced pipeline stage
NovartisBASEL, Switzerland
2 programs1
1
ABL001/AsciminibPhase 2Small Molecule1 trial
Gleevec/GlivecPhase 11 trial
Active Trials
AB
TakedaTOKYO, Japan
1 programponatinibN/ASmall Molecule1 trial
Active Trials
NCT01592136Approved For Marketing
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
2027
2028
NovartisABL001/Asciminib
NovartisGleevec/Glivec
AP BiosciencesCollection of blood and bone marrow
Clinical Trials (4)
Total enrollment: 23 patients across 4 trials
Open-label Study of Asciminib for CML-CP or CML-AP Patients With T315I Mutation Who Are Resistant, Intolerant or Ineligible to Ponatinib.
Start: Feb 2025Est. completion: Dec 202820 patients
Phase 2Recruiting
Glivec/Gleevec Pediatric (Age 1 to Less Than 4) PK Study in CML, Ph+ ALL Patients and Other Glivec/Gleevec® Indicated Hematological Disorders.
Start: Oct 20103 patients
Phase 1Terminated
Expanded Access Program of Ponatinib
N/AApproved For Marketing
EPIgenetics and in Vivo Resistance of Chronic Myeloid Leukemia Stem Cells to Tyrosine Kinase Inhibitors
Start: Feb 2018Est. completion: Feb 2026
N/ARecruiting
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Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
2 actively recruiting trials targeting 23 patients
3 companies competing in this space