Bacterial Infections

Infectious Diseases
31
Pipeline Programs
11
Companies
30
Clinical Trials
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
14
0
1
1
9
6
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Small Molecule
4100%
+ 25 programs with unclassified modality

On Market (3)

Approved therapies currently available

Pfizer
LINEZOLID IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINERApproved
linezolid
Pfizer
Oxazolidinone Antibacterial [EPC]intravenous2015
Paratek Pharmaceuticals
NUZYRAApproved
omadacycline
Paratek Pharmaceuticals
Tetracycline-class Antibacterial [EPC]oral2018
Pfizer
ZYVOXApproved
linezolid
Pfizer
Oxazolidinone Antibacterial [EPC]oral2000

Competitive Landscape

11 companies ranked by most advanced pipeline stage

Pfizer
PfizerNEW YORK, NY
8 programs
2
2
3
Piperacillin/TazobactamPhase 41 trial
TazocinPhase 41 trial
TazocinPhase 41 trial
LinezolidPhase 31 trial
Zyvox® / LinezolidPhase 31 trial
+3 more programs
Active Trials
NCT01788449Completed335Est. Feb 2007
NCT00678106Completed10Est. Jul 2009
NCT01058824Completed36Est. Apr 2009
+5 more trials
Paratek Pharmaceuticals
3 programs
1
2
1
OmadacyclinePhase 3Small Molecule1 trial
OmadacyclinePhase 3Small Molecule1 trial
Omadacycline Injection [Nuzyra]Phase 11 trial
Active Trials
NCT05217537Completed23Est. Feb 2025
NCT02877927Completed735Est. Jun 2017
NCT02378480Completed655Est. May 2016
M&
Merck & Co.RAHWAY, NJ
4 programs
4
PR5IPhase 31 trial
V419Phase 31 trial
V419Phase 31 trial
V419Phase 31 trial
Active Trials
NCT01480258Completed1,315Est. Oct 2013
NCT01337167Completed1,473Est. May 2013
NCT01340937Completed2,808Est. Jul 2013
+1 more trials
GC Biopharma
GC BiopharmaKorea - Yongin
2 programs
1
1
GC1107Phase 31 trial
GC1107Phase 2/31 trial
Active Trials
NCT01402713CompletedEst. Nov 2013
NCT02361866CompletedEst. Oct 2014
Debiopharm
DebiopharmSwitzerland - Lausanne
2 programs
1
1
Debio 1450 IVPhase 21 trial
Debio 1450Phase 11 trial
Active Trials
NCT02162199CompletedEst. Oct 2014
NCT02426918CompletedEst. Sep 2016
Evopoint Biosciences
Evopoint BiosciencesChina - Beijing
4 programs
4
XNW4107Phase 11 trial
XNW4107Phase 11 trial
XNW4107, Imipenem/CilastatinPhase 1Small Molecule1 trial
XNW4107, Imipenem/CilastatinPhase 1Small Molecule1 trial
Active Trials
NCT04482569Completed88Est. Sep 2021
NCT04801043Completed24Est. Jan 2022
NCT04787562Completed39Est. Feb 2022
+1 more trials
BioVersys
BioVersysSwitzerland - Basel
2 programs
2
BV100Phase 11 trial
BV100Phase 11 trial
Active Trials
NCT05684705Completed35Est. Dec 2024
NCT05684718Completed16Est. Oct 2023
BP
Basilea PharmaceuticaSwitzerland - Allschwil
1 program
1
Ceftobiprole medocarilPhase 11 trial
Active Trials
NCT02527681TerminatedEst. Feb 2020
AbbVie
AbbVieNORTH CHICAGO, IL
1 program
1
DalbavancinPhase 11 trial
Active Trials
NCT02688790Terminated8Est. Apr 2019
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
RO7223280Phase 12 trials
Active Trials
NCT05614895Completed48Est. Jan 2024
NCT04605718Completed124Est. Mar 2023
Allergy Therapeutics
Allergy TherapeuticsUK - West Sussex
1 program
1
TP-271Phase 11 trial
Active Trials
NCT03234738CompletedEst. Jan 2018

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
PfizerTazocin
PfizerTazocin
PfizerPiperacillin/Tazobactam
Paratek PharmaceuticalsOmadacycline
Paratek PharmaceuticalsOmadacycline
GC BiopharmaGC1107
Merck & Co.PR5I
Merck & Co.V419
Merck & Co.V419
Merck & Co.V419
PfizerLinezolid
PfizerZyvox® / Linezolid
GC BiopharmaGC1107
DebiopharmDebio 1450 IV
BioVersysBV100

Showing 15 of 30 trials with date data

Clinical Trials (30)

Total enrollment: 10,691 patients across 30 trials

Study Evaluation Tazocin Intervention

Start: May 2007Est. completion: Feb 2008134 patients
Phase 4Completed

Tazocin Intervention Study

Start: Sep 2006Est. completion: Jun 2007500 patients
Phase 4Completed
NCT00044928PfizerPiperacillin/Tazobactam

Study Evaluating Zosyn in Hospitalized Patients With Intra-abdominal Infection

Start: Jul 2002Est. completion: Feb 2004262 patients
Phase 4Completed

Oral Omadacycline vs. Oral Linezolid for the Treatment of ABSSSI

Start: Aug 2016Est. completion: Jun 2017735 patients
Phase 3Completed

Omadacycline Versus Linezolid for the Treatment of ABSSSI (EudraCT #2013-003644-23)

Start: Jun 2015Est. completion: May 2016655 patients
Phase 3Completed

To Evaluate the Effectiveness(Immunogeneicity) and Safety of 'GC1107' Administered Intramuscularly in Healthy Adults

Start: May 2014Est. completion: Oct 2014
Phase 3Completed

Safety, Tolerability, and Immunogenicity of V419 in Healthy Infants When Given at 2, 4, and 11 to 12 Months (V419-008)

Start: Nov 2011Est. completion: Oct 20131,315 patients
Phase 3Completed

Safety, Tolerability, and Immunogenicity of V419 in Healthy Infants When Given at 2, 3, 4 and 12 Months (V419-007)

Start: May 2011Est. completion: Mar 20131,250 patients
Phase 3Completed

A Study of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-006)

Start: May 2011Est. completion: Jul 20132,808 patients
Phase 3Completed

Safety, Tolerability, and Immunogenicity of V419 Given Concomitantly With Prevnar 13™ and RotaTeq™ (V419-005)

Start: Apr 2011Est. completion: May 20131,473 patients
Phase 3Completed

Antibiotic Treatment for Infections of Short Term In-dwelling Vascular Catheters Due to Gram Positive Bacteria

Start: Apr 2002Est. completion: Jul 2005739 patients
Phase 3Completed
NCT00035854PfizerZyvox® / Linezolid

New Antibiotic to Treat Pediatric Patients With Infections Due to a Specific Bacteria (Vancomycin-Resistant Enterococcus)

Start: Feb 2002Est. completion: May 200413 patients
Phase 3Completed

To Evaluate the Effectiveness(Immunogenicity) and Safety of 'GC1107' Administered Intramuscularly in Healthy Children

Start: Aug 2011Est. completion: Nov 2013
Phase 2/3Completed

Study of Debio 1450 for Bacterial Skin Infections

Start: May 2015Est. completion: Sep 2016
Phase 2Completed

Study to Investigate the Penetration of Rifabutin Into the Lung After Multiple Intravenous Administrations of BV100

Start: Sep 2023Est. completion: Dec 202435 patients
Phase 1Completed

To Evaluate the Effect of Multiple Doses of Itraconazole on the Pharmacokinetics of BV100

Start: Feb 2023Est. completion: Oct 202316 patients
Phase 1Completed

A Study to Investigate the Pharmacokinetics of RO7223280 in Critically Ill Participants With Bacterial Infections

Start: Dec 2022Est. completion: Jan 202448 patients
Phase 1Completed
NCT05217537Paratek PharmaceuticalsOmadacycline Injection [Nuzyra]

Study to Evaluate the PK of IV and PO Omadacycline in Children and Adolescents With Suspected or Confirmed Bacterial Infections

Start: Apr 2022Est. completion: Feb 202523 patients
Phase 1Completed
NCT04802863Evopoint BiosciencesXNW4107, Imipenem/Cilastatin

Intrapulmonary Pharmacokinetics of XNW4107, Imipenem and Cilastatin in Healthy Subjects

Start: Mar 2021Est. completion: Sep 202121 patients
Phase 1Completed

To Evaluate the Pharmacokinetics of XNW4107 in Healthy Adult Young Females and in Healthy Adult Elderly Males and Females.

Start: Mar 2021Est. completion: Jan 202224 patients
Phase 1Completed
NCT04787562Evopoint BiosciencesXNW4107, Imipenem/Cilastatin

Pharmacokinetics of XNW4107 in Subjects With Various Degrees of Renal Function

Start: Feb 2021Est. completion: Feb 202239 patients
Phase 1Completed

A Study To Investigate The Safety, Tolerability And Pharmacokinetics (PK) Of RO7223280 Following Intravenous Administration In Healthy Participants

Start: Dec 2020Est. completion: Mar 2023124 patients
Phase 1Completed

Study to Evaluate Safety, Tolerability, and Pharmacokinetics of XNW4107 Alone or in Combination With Imipenem/Cilastatin

Start: Jul 2020Est. completion: Sep 202188 patients
Phase 1Completed

A Phase 1 Safety and PK Study of IV TP-271

Start: Aug 2017Est. completion: Jan 2018
Phase 1Completed
NCT02527681Basilea PharmaceuticaCeftobiprole medocaril

Pharmacokinetics and Safety of Ceftobiprole in Neonates and Infants up to 3 Months Treated With Systemic Antibiotics

Start: Nov 2016Est. completion: Feb 2020
Phase 1Terminated

Study Evaluate the PK Profile of Dalbavancin in Infants and Neonates Patients With Known or Suspected Bacterial Infection

Start: Apr 2016Est. completion: Apr 20198 patients
Phase 1Terminated

A Single Dose Study of Debio 1450 in Healthy Subjects

Start: Jun 2014Est. completion: Oct 2014
Phase 1Completed

Relative Bioavailability Study Of Two Lincomycin Hydrochloride Hard Gelatinous Capsule

Start: Apr 2009Est. completion: Apr 200936 patients
Phase 1Completed

Study Of Dalbavancin Drug Levels Achieved In Hospitalized Adolescents Who Are Receiving Antibiotic Therapy For Bacterial Infections

Start: Sep 2008Est. completion: Jul 200910 patients
Phase 1Completed
NCT01788449PfizerStudy Evaluating the Association of Antibiotic Measures and Control of Bacterial Resistance

Study Evaluating the Association of Antibiotic Measures and Control of Bacterial Resistance

Start: May 2005Est. completion: Feb 2007335 patients
N/ACompleted

Related Jobs in Infectious Diseases

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

9 late-stage (Phase 3) programs — potential near-term approvals
11 companies competing in this space