Angelman Syndrome

Rare Diseases
11
Pipeline Programs
6
Companies
15
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
3
2
2
0
4
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

6 companies ranked by most advanced pipeline stage

Ultragenyx Pharmaceutical
4 programs
1
2
GTX-102Phase 31 trial
GTX-102Phase 31 trial
GTX-102Phase 1/21 trial
Newborn Screening AssayN/A1 trial
Active Trials
NCT05783791Completed11Est. Jul 2023
NCT04259281Completed74Est. Jan 2025
NCT06415344Enrolling By Invitation255Est. Feb 2029
+1 more trials
Ionis Pharmaceuticals
3 programs
1
1
ION582Phase 31 trial
ION582Phase 1/21 trial
Angelman Syndrome Video Assessment (ASVA) Source Material StudyN/A1 trial
Active Trials
NCT05637697Completed73Est. Aug 2023
NCT05127226Recruiting70Est. Mar 2029
NCT06914609Recruiting158Est. Apr 2030
Healx
HealxUK - Cambridge
3 programs
1
1
1
OV101Phase 31 trial
OV101 Regimen 1Phase 21 trial
OV101Phase 11 trial
Active Trials
NCT03109756CompletedEst. Nov 2017
NCT02996305CompletedEst. Aug 2018
NCT03882918TerminatedEst. Jun 2021
Roche
RocheSTAVANGER NORWAY, Norway
3 programs
1
1
AlogabatPhase 21 trial
RO7248824Phase 11 trial
Natural History StudyN/A1 trial
Active Trials
NCT05100810Unknown40Est. Dec 2024
NCT04863794Completed21Est. Aug 2022
NCT05630066Completed48Est. Dec 2025
Biogen
BiogenCAMBRIDGE, MA
1 program
1
Lumbar PuncturePhase 11 trial
Active Trials
NCT04103333Completed20Est. Jan 2022
Astellas
AstellasChina - Shenyang
1 program
A Natural History Study of Angelman SyndromeN/A1 trial
Active Trials
NCT07417137Not Yet Recruiting40Est. Sep 2029

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Ionis PharmaceuticalsION582
Ultragenyx PharmaceuticalGTX-102
Ultragenyx PharmaceuticalGTX-102
HealxOV101
RocheAlogabat
HealxOV101 Regimen 1
Ionis PharmaceuticalsION582
Ultragenyx PharmaceuticalGTX-102
RocheRO7248824
BiogenLumbar Puncture
HealxOV101
AstellasA Natural History Study of Angelman Syndrome
Ultragenyx PharmaceuticalNewborn Screening Assay
RocheNatural History Study
Ionis PharmaceuticalsAngelman Syndrome Video Assessment (ASVA) Source Material Study

Clinical Trials (15)

Total enrollment: 939 patients across 15 trials

REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

Start: Jun 2025Est. completion: Apr 2030158 patients
Phase 3Recruiting

Phase 3 Efficacy and Safety Study of GTX-102 in Pediatric Subjects With Angelman Syndrome (AS)

Start: Dec 2024Est. completion: Nov 2027129 patients
Phase 3Active Not Recruiting

Long-term Extension of GTX-102 in Angelman Syndrome

Start: Jul 2024Est. completion: Feb 2029255 patients
Phase 3Enrolling By Invitation

An Open-Label Study to Evaluate the Long-Term Safety, Tolerability, and Efficacy of OV101 in Individuals With Angelman Syndrome

Start: Jan 2019Est. completion: Jun 2021
Phase 3Terminated

A Study to Investigate the Pharmacokinetics (PK) and Safety and to Provide Proof of Mechanism of Alogabat in Children and Adolescents Aged 5-17 Years With Angelman Syndrome (AS) With Deletion Genotype.

Start: Jul 2023Est. completion: Dec 202548 patients
Phase 2Completed
NCT02996305HealxOV101 Regimen 1

A Study in Adults and Adolescents With Angelman Syndrome (STARS)

Start: Jan 2016Est. completion: Aug 2018
Phase 2Completed

HALOS: A Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of Multiple Ascending Doses of ION582 in Participants With Angelman Syndrome

Start: Dec 2021Est. completion: Mar 202970 patients
Phase 1/2Recruiting

A Study of the Safety and Tolerability of GTX-102 in Children With Angelman Syndrome

Start: Feb 2020Est. completion: Jan 202574 patients
Phase 1/2Completed

A Study To Assess Distribution Of RO7248824 In The Central Nervous System Following Single Intrathecal Doses Of [89zr] Labeled RO7248824 In Healthy Male Participants

Start: Apr 2021Est. completion: Aug 202221 patients
Phase 1Completed
NCT04103333BiogenLumbar Puncture

Angelman Syndrome (AS) Biomarker Study

Start: Dec 2019Est. completion: Jan 202220 patients
Phase 1Completed

Single Dose Pharmacokinetic (PK) Study

Start: Apr 2017Est. completion: Nov 2017
Phase 1Completed
NCT07417137AstellasA Natural History Study of Angelman Syndrome

A Natural History Study of Angelman Syndrome

Start: Mar 2026Est. completion: Sep 202940 patients
N/ANot Yet Recruiting

Development of a Newborn Screening Assay for Angelman Syndrome and Prader-Willi Syndrome

Start: Apr 2023Est. completion: Jul 202311 patients
N/ACompleted
NCT05100810RocheNatural History Study

Angelman Syndrome Natural History Study-FAST UK

Start: Nov 2021Est. completion: Dec 202440 patients
N/AUnknown
NCT05637697Ionis PharmaceuticalsAngelman Syndrome Video Assessment (ASVA) Source Material Study

Angelman Syndrome Video Assessment (ASVA) Source Material Study

Start: Aug 2021Est. completion: Aug 202373 patients
N/ACompleted

Related Jobs in Rare Diseases

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 939 patients
6 companies competing in this space