Lacer
Spain - Barcelona
BiotechnologyFocus: Small Molecules
Lacer is a life sciences company focused on Small Molecules.
Open Jobs
0
Products & Portfolio (2)
ERTACZO
sertaconazole nitrate
LOE Approaching
TOPICAL · CREAM
12.1 Mechanism of Action Sertaconazole nitrate is an azole antifungal [see ] . 12.2 Pharmacokinetics In a multiple-dose pharmacokinetic trial that included 5 male subjects with interdigital tinea pedis (range of diseased area, 42 - 140 cm ; mean, 93 cm ), ERTACZO cream, 2%, was topically applied every 12 hours for a total of 13 doses to the diseased skin (0.5 g sertaconazole nitrate per 100 cm ). Sertaconazole concentrations in plasma measured by serial blood sampling for 72 hours after the thirteenth dose were below the limit of quantitation (2.5 ng/mL) of the analytical method used. 12.3 Microbiology Mechanism of Action Sertaconazole, an azole antifungal agent, inhibits fungal cytochrome P-450-mediated 14 alpha-lanosterol demethylase enzyme. This enzyme functions to convert lanosterol to ergosterol. Ergosterol is a key component of fungal cell membranes and lack of this component leads to fungal cell injury by leakage of key constituents in the cytoplasm from the cell. Activity In Vitro and in Clinical Infections Sertaconazole nitrate has been shown to be active against isolates of the following microorganisms in clinical infections [see ] : Trichophyton rubrum Trichophyton mentagrophytes Epidermophyton floccosum
2003
30
ULTRAVATE
halobetasol propionate
Peak
TOPICAL · LOTION
2015
0
Open Jobs (0)
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Interview Prep Quick Facts
Portfolio: 2 approved products
Portfolio Health
Peak1 (50%)
LOE Approaching1 (50%)
2 total products