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Periodontitis

5
Pipeline Programs
10
Companies
17
Clinical Trials
2 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
2
0
2
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
2 programs
1
minocycline HCl microspheresPhase 41 trial
SRP + MMN/A1 trial
Active Trials
NCT05422742Active Not Recruiting50Est. Dec 2025
NCT03762915Completed70Est. Apr 2022
Kaken Pharmaceutical
4 programs
2
2
TraferminPhase 31 trial
TraferminPhase 31 trial
TraferminPhase 21 trial
TraferminPhase 21 trial
Active Trials
NCT00514657Completed91Est. Feb 2004
NCT00199290Completed267Est. Dec 2007
NCT00734708Completed328
+1 more trials
Geistlich Pharma
Geistlich PharmaSwitzerland - Root
4 programs
Access flap & surgical debridementN/A1 trial
Polynucleotide and hyaluronic acid-based gelN/A1 trial
PerioSeptPHASE_1_21 trial
PerioSeptPHASE_21 trial
Active Trials
NCT06270303Recruiting200Est. Mar 2037
NCT07522684Recruiting66Est. May 2028
NCT02313883Completed127Est. Jul 2018
+1 more trials
Philips
PhilipsNetherlands - Amsterdam
1 program
ADA approved Manual ToothbrushN/A1 trial
Active Trials
NCT04254770Completed346Est. Aug 2020
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
Accuracy of Extra-oral Bite-wing Radiography in Detecting Calculus and Crestal Bone LossN/A1 trial
Active Trials
NCT05887128Unknown80Est. Jun 2025
Martin Pharmaceuticals
1 program
Periodontitis and Coronary Heart DiseaseN/A1 trial
Active Trials
NCT01045070Completed960Est. May 2012
Ondine Biomedical
Ondine BiomedicalBC - Vancouver
1 program
light activated dye photodynamic therapyN/A1 trial
Active Trials
NCT03270254Completed31Est. Sep 2018
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
periodontal therapyN/A1 trial
Active Trials
NCT05183321Not Yet Recruiting190Est. Dec 2026
Lacer
LacerSpain - Barcelona
1 program
test mouth rinseN/A1 trial
Active Trials
NCT04881357Completed30Est. Jul 2022
Baxter International
1 program
Fibrin SealantPHASE_41 trial
Active Trials
NCT01538927Completed15Est. Dec 2012

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Bausch Healthminocycline HCl microspheres
Baxter InternationalFibrin Sealant
Kaken PharmaceuticalTrafermin
Kaken PharmaceuticalTrafermin
Geistlich PharmaPerioSept
Kaken PharmaceuticalTrafermin
Kaken PharmaceuticalTrafermin
Geistlich PharmaPerioSept
Geistlich PharmaPolynucleotide and hyaluronic acid-based gel
Geistlich PharmaAccess flap & surgical debridement
UNION therapeuticsperiodontal therapy
Colorado TherapeuticsAccuracy of Extra-oral Bite-wing Radiography in Detecting Calculus and Crestal Bone Loss
Bausch HealthSRP + MM
Lacertest mouth rinse
PhilipsADA approved Manual Toothbrush

Showing 15 of 17 trials with date data

Clinical Trials (17)

Total enrollment: 2,888 patients across 17 trials

NCT03762915Bausch Healthminocycline HCl microspheres

Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg

Start: May 2019Est. completion: Apr 202270 patients
Phase 4Completed
NCT01538927Baxter InternationalFibrin Sealant

Effect of Fibrin Sealant on Early Wound Healing

Start: Apr 2012Est. completion: Dec 201215 patients
Phase 4Completed
NCT01015404Kaken PharmaceuticalTrafermin

A Study to Assess the Safety of Using Fibroblast Growth Factor-2 With Periodontal Surgery in Japan (Phase 3)

Start: Nov 200925 patients
Phase 3Completed
NCT00734708Kaken PharmaceuticalTrafermin

Phase 3 Clinical Trial of Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2(Trafermin)

Start: Aug 2008328 patients
Phase 3Completed
NCT04093895Geistlich PharmaPerioSept

Trial to Evaluate Safety, Tolerability, Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis

Start: Aug 2019Est. completion: Sep 202012 patients
Phase 2Completed
NCT00199290Kaken PharmaceuticalTrafermin

A Phase2 Clinical Trial of Trafermin in Patients With Marginal Periodontitis in Japan

Start: Aug 2005Est. completion: Dec 2007267 patients
Phase 2Completed
NCT00514657Kaken PharmaceuticalTrafermin

Trial in Periodontal Tissue Regeneration Using Fibroblast Growth Factor-2

Start: Dec 2001Est. completion: Feb 200491 patients
Phase 2Completed
NCT02313883Geistlich PharmaPerioSept

A Phase I/II Study to Evaluate the Safety and Efficacy of PerioSept® as Adjunct to SRP in Subjects With Periodontitis

Start: Jul 2015Est. completion: Jul 2018127 patients
Phase 1/2Completed
NCT07522684Geistlich PharmaPolynucleotide and hyaluronic acid-based gel

Polynucleotide + Hyaluronic Acid Gel With Xenogeneic Graft for Intrabony Periodontal Defects

Start: Feb 2026Est. completion: May 202866 patients
N/ARecruiting
NCT06270303Geistlich PharmaAccess flap & surgical debridement

Use of a Bone Substitute Material in the Surgical Therapy of Furcation Defects

Start: Mar 2025Est. completion: Mar 2037200 patients
N/ARecruiting
NCT05183321UNION therapeuticsperiodontal therapy

Treatment of Periodontal Disease in Patients With Alzheimer's Disease

Start: Jun 2024Est. completion: Dec 2026190 patients
N/ANot Yet Recruiting
NCT05887128Colorado TherapeuticsAccuracy of Extra-oral Bite-wing Radiography in Detecting Calculus and Crestal Bone Loss

Accuracy of Extra-oral Bite-wing Radiography in Detecting Calculus and Crestal Bone Loss

Start: Jun 2023Est. completion: Jun 202580 patients
N/AUnknown
NCT05422742Bausch HealthSRP + MM

Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities

Start: Oct 2021Est. completion: Dec 202550 patients
N/AActive Not Recruiting
NCT04881357Lacertest mouth rinse

Antiplaque/Antigingivitis Effect of Lacer Oros Integral

Start: Sep 2021Est. completion: Jul 202230 patients
N/ACompleted
NCT04254770PhilipsADA approved Manual Toothbrush

At-Home Care for Subjects With Periodontitis

Start: Jan 2020Est. completion: Aug 2020346 patients
N/ACompleted
NCT03270254Ondine Biomedicallight activated dye photodynamic therapy

Photodynamic Therapy Plus Root Debridement in Gum Disease Treatment V2

Start: Oct 2017Est. completion: Sep 201831 patients
N/ACompleted
NCT01045070Martin PharmaceuticalsPeriodontitis and Coronary Heart Disease

Periodontitis and Coronary Heart Disease

Start: Oct 2009Est. completion: May 2012960 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

2 late-stage (Phase 3) programs, potential near-term approvals
2 actively recruiting trials targeting 2,888 patients
10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.