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Gingivitis

10
Pipeline Programs
11
Companies
28
Clinical Trials
1 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
1
2
0
1
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
8 programs
1
1
1
2
Chlorhexidine Digluconate Mouthwash with AlcoholPhase 4
Sensodyne Repair and ProtectPhase 4
Stannous fluoridePhase 3
Experimental DentrifricePhase 2
isopropylmethylphenol and FluoridePhase 1
+3 more programs
Ostia Sciences
Ostia SciencesON - Toronto
2 programs
1
6B SALI-10Phase 21 trial
3B SALI-10 LozengeN/A1 trial
Active Trials
NCT07508839Not Yet Recruiting60Est. Apr 2027
NCT07256743Recruiting60Est. Jun 2026
Amyndas Pharmaceuticals
Amyndas PharmaceuticalsGreece - Glyfada
1 program
1
AMY-101Phase 1/21 trial
Active Trials
NCT03694444Completed39Est. Oct 2020
BioTherapeutics Inc
BioTherapeutics IncVA - Blacksburg
1 program
1
1X ACCSPhase 11 trial
Active Trials
NCT02071199Completed54Est. Dec 2015
Noveome Biotherapeutics
1 program
1
1X ACCSPhase 1
Next Science
Next ScienceAustralia - Sydney
1 program
1
Next Science OTC Oral Rinse with Essential OilsPhase 11 trial
Active Trials
NCT03154021Completed118Est. May 2018
GSK
GSKLONDON, United Kingdom
8 programs
Sodium bicarbonateN/A1 trial
Stannous FluorideN/A1 trial
Stannous fluorideN/A1 trial
isopropylmethylphenol and FluoridePHASE_11 trial
Experimental DentrifricePHASE_21 trial
+3 more programs
Active Trials
NCT03703245Completed1,601Est. Nov 2019
NCT02750943Completed253Est. Mar 2016
NCT02937636Completed128Est. Dec 2017
+5 more trials
Philips
PhilipsNetherlands - Amsterdam
4 programs
AirFloss + BreathRxN/A1 trial
AirflosserN/A1 trial
Manual Toothbrush onlyN/A1 trial
Sonicare InterproximalN/A1 trial
Active Trials
NCT02187016Completed290Est. Jul 2014
NCT01700348Terminated257Est. Feb 2013
NCT01559987Completed270Est. May 2012
+1 more trials
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
3 programs
Interdental cleaning device with waterN/A1 trial
Mouth Rinse 19668-012N/A1 trial
Colgate Cavity Protection ToothpastePHASE_45 trials
Active Trials
NCT01419626Completed140Est. Aug 2011
NCT01821261Withdrawn0Est. Jul 2014
NCT05645705Completed270Est. Dec 2022
+4 more trials
Lacer
LacerSpain - Barcelona
2 programs
Gingivitis toothpasteN/A1 trial
Mouthwash for delicate gumsN/A1 trial
Active Trials
NCT07494747Not Yet Recruiting60Est. Sep 2026
NCT07551908Not Yet Recruiting30Est. Jul 2026
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
GumChucksN/A1 trial
applying COMORAL®N/A1 trial
Active Trials
NCT04057430Completed40Est. Feb 2017
NCT05031260Not Yet Recruiting42Est. Jun 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Johnson & JohnsonColgate Cavity Protection Toothpaste
Johnson & JohnsonColgate Cavity Protection Toothpaste
Johnson & JohnsonColgate Cavity Protection Toothpaste
Johnson & JohnsonColgate Cavity Protection Toothpaste
GSKSensodyne Repair and Protect
Johnson & JohnsonColgate Cavity Protection Toothpaste
GSKChlorhexidine Digluconate Mouthwash with Alcohol
GSKStannous fluoride
Ostia Sciences6B SALI-10
GSKExperimental Dentrifrice
Amyndas PharmaceuticalsAMY-101
Next ScienceNext Science OTC Oral Rinse with Essential Oils
BioTherapeutics Inc1X ACCS
GSKisopropylmethylphenol and Fluoride
LacerMouthwash for delicate gums

Showing 15 of 28 trials with date data

Clinical Trials (28)

Total enrollment: 5,266 patients across 28 trials

NCT05645705Johnson & JohnsonColgate Cavity Protection Toothpaste

A Two-Week Study of Clinical Safety and Saliva Flow Quantification

Start: Nov 2022Est. completion: Dec 2022270 patients
Phase 4Completed
NCT05120141Johnson & JohnsonColgate Cavity Protection Toothpaste

A Twelve Week Study of Experimental Mouth Rinses

Start: Mar 2021Est. completion: Jul 2021300 patients
Phase 4Completed
NCT04750005Johnson & JohnsonColgate Cavity Protection Toothpaste

A Twelve Week Study of Virtually Supervised Mouth Rinse and Flossing

Start: Oct 2020Est. completion: Feb 2021209 patients
Phase 4Completed
NCT04449952Johnson & JohnsonColgate Cavity Protection Toothpaste

A Study of Mouth Rinses in Type 1 and Type 2 Diabetic Participants

Start: Dec 2019Est. completion: Mar 2020154 patients
Phase 4Completed
NCT04050722GSKSensodyne Repair and Protect

A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks

Start: Oct 2019Est. completion: Nov 2019130 patients
Phase 4Completed
NCT04696536Johnson & JohnsonColgate Cavity Protection Toothpaste

A Twelve Week Study of Supervised Mouth Rinse and Flossing

Start: Sep 2018Est. completion: Dec 2018149 patients
Phase 4Completed
NCT01751178GSKChlorhexidine Digluconate Mouthwash with Alcohol

An Efficacy Study of Chlorhexidine Mouthwashes

Start: Oct 2012Est. completion: Mar 2013324 patients
Phase 4Completed
NCT04123665GSKStannous fluoride

A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride

Start: May 2013Est. completion: Dec 201398 patients
Phase 3Completed

Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis

Start: Sep 2025Est. completion: Jun 202660 patients
Phase 2Recruiting
NCT04737538GSKExperimental Dentrifrice

A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis

Start: Feb 2021Est. completion: Jul 2021110 patients
Phase 2Completed

A Study of the C3 Complement Inhibitor AMY-101 in Adults With Gingivitis

Start: Jul 2019Est. completion: Oct 202039 patients
Phase 1/2Completed
NCT03154021Next ScienceNext Science OTC Oral Rinse with Essential Oils

Next Science Antimicrobial Mouth Rinse Study

Start: Aug 2017Est. completion: May 2018118 patients
Phase 1Completed

Treatment of Human Gingivitis With Amnion-derived Cellular Cytokine Solution (ACCS)

Start: Mar 2014Est. completion: Dec 201554 patients
Phase 1Completed
NCT01079910GSKisopropylmethylphenol and Fluoride

To Investigate the Clinical Efficacy of an Experimental Toothpaste

Start: Dec 2009Est. completion: Dec 20090
Phase 1Withdrawn
NCT07551908LacerMouthwash for delicate gums

Evaluation of the Effect of the Mouthwash on Delicate Gums

Start: Apr 2026Est. completion: Jul 202630 patients
N/ANot Yet Recruiting
NCT07508839Ostia Sciences3B SALI-10 Lozenge

Evaluation of the Safety and Efficacy of SALI-10 Probiotic Lozenges

Start: Apr 2026Est. completion: Apr 202760 patients
N/ANot Yet Recruiting
NCT07494747LacerGingivitis toothpaste

Evaluation of the Effect of the Toothpaste on Delicate Gums

Start: Mar 2026Est. completion: Sep 202660 patients
N/ANot Yet Recruiting

COMORAL® the Oral Irrigation Unit Clinical Trial

Start: Oct 2021Est. completion: Jun 202242 patients
N/ANot Yet Recruiting
NCT03703245GSKSodium bicarbonate

Pooled Analysis of Clinical Data From Six GSK Studies to Investigate the Efficacy of a Dentifrice Containing 67% Weight by Weight (w/w) Sodium Bicarbonate on Gingivitis and Plaque Accumulation

Start: Apr 2019Est. completion: Nov 20191,601 patients
N/ACompleted
NCT02937636GSKStannous fluoride

To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population

Start: Sep 2017Est. completion: Dec 2017128 patients
N/ACompleted

Effectiveness of the GumChucks® Flossing System Compared to String Floss for Interdental Plaque Removal in Children

Start: Dec 2016Est. completion: Feb 201740 patients
N/ACompleted
NCT02750943GSKStannous Fluoride

Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease

Start: Nov 2015Est. completion: Mar 2016253 patients
N/ACompleted
NCT02187016PhilipsAirFloss + BreathRx

Efficacy and Safety Study of Interproximal Cleaning Modalities on Oral Health

Start: Jun 2014Est. completion: Jul 2014290 patients
N/ACompleted
NCT01821261Johnson & JohnsonMouth Rinse 19668-012

A Clinical Trial to Test the Effect of an Experimental Mouth Rinse on Gum Disease

Start: Apr 2014Est. completion: Jul 20140
N/AWithdrawn

Philips AirFlosser Study

Start: Aug 2012Est. completion: Feb 2013257 patients
N/ATerminated
NCT01559987PhilipsManual Toothbrush only

Dental Plaque Removal Study

Start: Feb 2012Est. completion: May 2012270 patients
N/ACompleted
NCT01419626Johnson & JohnsonInterdental cleaning device with water

A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen

Start: Jul 2011Est. completion: Aug 2011140 patients
N/ACompleted
NCT01307358PhilipsSonicare Interproximal

A Study Comparing the Interproximal Plaque and Gingivitis Effects of Three Interdental Cleaning Modalities

Start: Feb 2011Est. completion: Apr 201180 patients
N/ACompleted

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
1 actively recruiting trials targeting 5,266 patients
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.