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Gingivitis

10
Pipeline Programs
11
Companies
28
Clinical Trials
3 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
4
1
2
0
1
2
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
8 programs
1
1
1
2
Chlorhexidine Digluconate Mouthwash with AlcoholPhase 41 trial
Sensodyne Repair and ProtectPhase 41 trial
Stannous fluoridePhase 31 trial
Experimental DentrifricePhase 21 trial
isopropylmethylphenol and FluoridePhase 11 trial
+3 more programs
Active Trials
NCT03703245Completed1,601Est. Nov 2019
NCT02750943Completed253Est. Mar 2016
NCT02937636Completed128Est. Dec 2017
+5 more trials
Ostia Sciences
Ostia SciencesON - Toronto
2 programs
1
6B SALI-10Phase 21 trial
3B SALI-10 LozengeN/A1 trial
Active Trials
NCT07508839Recruiting60Est. Apr 2027
NCT07256743Recruiting60Est. Jun 2026
Amyndas Pharmaceuticals
Amyndas PharmaceuticalsGreece - Glyfada
1 program
1
AMY-101Phase 1/21 trial
Active Trials
NCT03694444Completed39Est. Oct 2020
BioTherapeutics Inc
BioTherapeutics IncVA - Blacksburg
1 program
1
1X ACCSPhase 1
Noveome Biotherapeutics
1 program
1
1X ACCSPhase 11 trial
Active Trials
NCT02071199Completed54Est. Dec 2015
Next Science
Next ScienceAustralia - Sydney
1 program
1
Next Science OTC Oral Rinse with Essential OilsPhase 11 trial
Active Trials
NCT03154021Completed118Est. May 2018
GSK
GSKLONDON, United Kingdom
8 programs
Sodium bicarbonateN/A
Stannous FluorideN/A
Stannous fluorideN/A
isopropylmethylphenol and FluoridePHASE_1
Experimental DentrifricePHASE_2
+3 more programs
Philips
PhilipsNetherlands - Amsterdam
4 programs
AirFloss + BreathRxN/A1 trial
AirflosserN/A1 trial
Manual Toothbrush onlyN/A1 trial
Sonicare InterproximalN/A1 trial
Active Trials
NCT02187016Completed290Est. Jul 2014
NCT01700348Terminated257Est. Feb 2013
NCT01559987Completed270Est. May 2012
+1 more trials
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
3 programs
Interdental cleaning device with waterN/A1 trial
Mouth Rinse 19668-012N/A1 trial
Colgate Cavity Protection ToothpastePHASE_45 trials
Active Trials
NCT01419626Completed140Est. Aug 2011
NCT01821261Withdrawn0Est. Jul 2014
NCT05645705Completed270Est. Dec 2022
+4 more trials
Lacer
LacerSpain - Barcelona
2 programs
Gingivitis toothpasteN/A1 trial
Mouthwash for delicate gumsN/A1 trial
Active Trials
NCT07494747Recruiting60Est. Sep 2026
NCT07551908Completed33Est. Jul 2026
Angeles Therapeutics
Angeles TherapeuticsCA - Los Angeles
2 programs
GumChucksN/A1 trial
applying COMORAL®N/A1 trial
Active Trials
NCT04057430Completed40Est. Feb 2017
NCT05031260Not Yet Recruiting42Est. Jun 2022

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
Johnson & JohnsonColgate Cavity Protection Toothpaste
Johnson & JohnsonColgate Cavity Protection Toothpaste
Johnson & JohnsonColgate Cavity Protection Toothpaste
Johnson & JohnsonColgate Cavity Protection Toothpaste
ViiV HealthcareSensodyne Repair and Protect
Johnson & JohnsonColgate Cavity Protection Toothpaste
ViiV HealthcareChlorhexidine Digluconate Mouthwash with Alcohol
ViiV HealthcareStannous fluoride
Ostia Sciences6B SALI-10
ViiV HealthcareExperimental Dentrifrice
Amyndas PharmaceuticalsAMY-101
Next ScienceNext Science OTC Oral Rinse with Essential Oils
Noveome Biotherapeutics1X ACCS
ViiV Healthcareisopropylmethylphenol and Fluoride
Ostia Sciences3B SALI-10 Lozenge

Showing 15 of 28 trials with date data

Clinical Trials (28)

Total enrollment: 5,269 patients across 28 trials

NCT05645705Johnson & JohnsonColgate Cavity Protection Toothpaste

A Two-Week Study of Clinical Safety and Saliva Flow Quantification

Start: Nov 2022Est. completion: Dec 2022270 patients
Phase 4Completed
NCT05120141Johnson & JohnsonColgate Cavity Protection Toothpaste

A Twelve Week Study of Experimental Mouth Rinses

Start: Mar 2021Est. completion: Jul 2021300 patients
Phase 4Completed
NCT04750005Johnson & JohnsonColgate Cavity Protection Toothpaste

A Twelve Week Study of Virtually Supervised Mouth Rinse and Flossing

Start: Oct 2020Est. completion: Feb 2021209 patients
Phase 4Completed
NCT04449952Johnson & JohnsonColgate Cavity Protection Toothpaste

A Study of Mouth Rinses in Type 1 and Type 2 Diabetic Participants

Start: Dec 2019Est. completion: Mar 2020154 patients
Phase 4Completed
NCT04050722ViiV HealthcareSensodyne Repair and Protect

A Clinical Study Investigating the Efficacy of a Stannous Fluoride Dentifrice in Improving Gingival Health After Twice Daily Use for 3 Weeks

Start: Oct 2019Est. completion: Nov 2019130 patients
Phase 4Completed
NCT04696536Johnson & JohnsonColgate Cavity Protection Toothpaste

A Twelve Week Study of Supervised Mouth Rinse and Flossing

Start: Sep 2018Est. completion: Dec 2018149 patients
Phase 4Completed
NCT01751178ViiV HealthcareChlorhexidine Digluconate Mouthwash with Alcohol

An Efficacy Study of Chlorhexidine Mouthwashes

Start: Oct 2012Est. completion: Mar 2013324 patients
Phase 4Completed

A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride

Start: May 2013Est. completion: Dec 201398 patients
Phase 3Completed

Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis

Start: Sep 2025Est. completion: Jun 202660 patients
Phase 2Recruiting
NCT04737538ViiV HealthcareExperimental Dentrifrice

A Proof-of-principle Clinical Study Investigating the Efficacy of an Experimental Dentifrice Containing Sodium Bicarbonate and Sodium Hyaluronate on Gingivitis

Start: Feb 2021Est. completion: Jul 2021110 patients
Phase 2Completed

A Study of the C3 Complement Inhibitor AMY-101 in Adults With Gingivitis

Start: Jul 2019Est. completion: Oct 202039 patients
Phase 1/2Completed
NCT03154021Next ScienceNext Science OTC Oral Rinse with Essential Oils

Next Science Antimicrobial Mouth Rinse Study

Start: Aug 2017Est. completion: May 2018118 patients
Phase 1Completed

Treatment of Human Gingivitis With Amnion-derived Cellular Cytokine Solution (ACCS)

Start: Mar 2014Est. completion: Dec 201554 patients
Phase 1Completed
NCT01079910ViiV Healthcareisopropylmethylphenol and Fluoride

To Investigate the Clinical Efficacy of an Experimental Toothpaste

Start: Dec 2009Est. completion: Dec 20090
Phase 1Withdrawn
NCT07508839Ostia Sciences3B SALI-10 Lozenge

Evaluation of the Safety and Efficacy of SALI-10 Probiotic Lozenges

Start: May 2026Est. completion: Apr 202760 patients
N/ARecruiting
NCT07494747LacerGingivitis toothpaste

Evaluation of the Effect of the Toothpaste on Delicate Gums

Start: Mar 2026Est. completion: Sep 202660 patients
N/ARecruiting
NCT07551908LacerMouthwash for delicate gums

Evaluation of the Effect of the Mouthwash on Delicate Gums

Start: Mar 2026Est. completion: Jul 202633 patients
N/ACompleted

COMORAL® the Oral Irrigation Unit Clinical Trial

Start: Oct 2021Est. completion: Jun 202242 patients
N/ANot Yet Recruiting
NCT03703245ViiV HealthcareSodium bicarbonate

Pooled Analysis of Clinical Data From Six GSK Studies to Investigate the Efficacy of a Dentifrice Containing 67% Weight by Weight (w/w) Sodium Bicarbonate on Gingivitis and Plaque Accumulation

Start: Apr 2019Est. completion: Nov 20191,601 patients
N/ACompleted

To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population

Start: Sep 2017Est. completion: Dec 2017128 patients
N/ACompleted

Effectiveness of the GumChucks® Flossing System Compared to String Floss for Interdental Plaque Removal in Children

Start: Dec 2016Est. completion: Feb 201740 patients
N/ACompleted

Potential of Stannous Fluoride Toothpaste to Reduce Gum Disease

Start: Nov 2015Est. completion: Mar 2016253 patients
N/ACompleted
NCT02187016PhilipsAirFloss + BreathRx

Efficacy and Safety Study of Interproximal Cleaning Modalities on Oral Health

Start: Jun 2014Est. completion: Jul 2014290 patients
N/ACompleted
NCT01821261Johnson & JohnsonMouth Rinse 19668-012

A Clinical Trial to Test the Effect of an Experimental Mouth Rinse on Gum Disease

Start: Apr 2014Est. completion: Jul 20140
N/AWithdrawn

Philips AirFlosser Study

Start: Aug 2012Est. completion: Feb 2013257 patients
N/ATerminated
NCT01559987PhilipsManual Toothbrush only

Dental Plaque Removal Study

Start: Feb 2012Est. completion: May 2012270 patients
N/ACompleted
NCT01419626Johnson & JohnsonInterdental cleaning device with water

A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen

Start: Jul 2011Est. completion: Aug 2011140 patients
N/ACompleted
NCT01307358PhilipsSonicare Interproximal

A Study Comparing the Interproximal Plaque and Gingivitis Effects of Three Interdental Cleaning Modalities

Start: Feb 2011Est. completion: Apr 201180 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs, potential near-term approvals
3 actively recruiting trials targeting 5,269 patients
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.