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Xerostomia

3
Pipeline Programs
10
Companies
12
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
2
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Otsuka
OtsukaJapan - Tokushima
1 program
1
RebamipidePhase 21 trial
Active Trials
NCT00233363Completed104Est. Jan 2006
ViiV Healthcare
ViiV HealthcareNC - Durham
4 programs
1
MighTeaFlowPhase 1/21 trial
Biotene mouthwashN/A1 trial
Biotene mouthwashN/A1 trial
Experimental Oralbalance Moisturizing GelN/A1 trial
Active Trials
NCT03005041Completed56Est. Oct 2016
NCT02641912Completed100Est. Apr 2016
NCT03494985Completed422Est. Jan 2014
+1 more trials
Parion Sciences
Parion SciencesNC - Durham
1 program
1
P-552Phase 1/21 trial
Active Trials
NCT01369589Completed24Est. Apr 2011
GSK
GSKLONDON, United Kingdom
4 programs
Biotene mouthwashN/A
Biotene mouthwashN/A
Experimental Oralbalance Moisturizing GelN/A
MighTeaFlowPHASE_1_2
Solventum
SolventumMN - St. Paul
1 program
3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth SprayN/A1 trial
Active Trials
NCT04186806Completed40Est. Dec 2019
Helsinn
HelsinnIreland - Dublin
1 program
AqualiefN/A1 trial
Active Trials
NCT03601962Terminated100Est. Jan 2020
Innovation Pharmaceuticals
1 program
Gel-based artificial salivaN/A1 trial
Active Trials
NCT02317172Completed120Est. Mar 2013
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
Remineralizing Extreme Dry Mouth Spray with XylitolN/A1 trial
Active Trials
NCT04608773Completed129Est. Jun 2023
Jerusalem Pharmaceuticals
Jerusalem PharmaceuticalsIsrael - Ramallah
1 program
ElectrostimulationPHASE_41 trial
Active Trials
NCT00509808Completed200Est. Apr 2010
Camurus
CamurusSweden - Lund
1 program
XER2020PHASE_41 trial
Active Trials
NCT01316393Completed20Est. Jun 2011

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
CamurusXER2020
Jerusalem PharmaceuticalsElectrostimulation
OtsukaRebamipide
ViiV HealthcareMighTeaFlow
Parion SciencesP-552
Johnson & JohnsonRemineralizing Extreme Dry Mouth Spray with Xylitol
Solventum3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth Spray
HelsinnAqualief
ViiV HealthcareBiotene mouthwash
ViiV HealthcareBiotene mouthwash
ViiV HealthcareExperimental Oralbalance Moisturizing Gel
Innovation PharmaceuticalsGel-based artificial saliva

Clinical Trials (12)

Total enrollment: 1,375 patients across 12 trials

NCT01316393CamurusXER2020

Effects of Mucoprotective Product on Xerostomia

Start: Feb 2011Est. completion: Jun 201120 patients
Phase 4Completed
NCT00509808Jerusalem PharmaceuticalsElectrostimulation

Evaluation of an Electro-stimulator for the Treatment of Xerostomia

Start: Jan 2007Est. completion: Apr 2010200 patients
Phase 4Completed
NCT00233363OtsukaRebamipide

Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome

Start: Apr 2005Est. completion: Jan 2006104 patients
Phase 2Completed
NCT01647737ViiV HealthcareMighTeaFlow

Green Tea Lozenges for the Management of Dry Mouth

Start: Mar 2011Est. completion: Jun 201360 patients
Phase 1/2Completed
NCT01369589Parion SciencesP-552

An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness

Start: Nov 2010Est. completion: Apr 201124 patients
Phase 1/2Completed
NCT04608773Johnson & JohnsonRemineralizing Extreme Dry Mouth Spray with Xylitol

Blinded Dry Mouth Spray Crossover Study

Start: Jan 2021Est. completion: Jun 2023129 patients
N/ACompleted
NCT04186806Solventum3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth Spray

Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray

Start: Nov 2019Est. completion: Dec 201940 patients
N/ACompleted
NCT03601962HelsinnAqualief

Effects of Aqualief® in Patients With Xerostomia as Consequence of Radiotherapy for Head and Neck Cancer

Start: Jul 2017Est. completion: Jan 2020100 patients
N/ATerminated
NCT03005041ViiV HealthcareBiotene mouthwash

Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects

Start: Aug 2016Est. completion: Oct 201656 patients
N/ACompleted
NCT02641912ViiV HealthcareBiotene mouthwash

Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms

Start: Mar 2016Est. completion: Apr 2016100 patients
N/ACompleted
NCT03494985ViiV HealthcareExperimental Oralbalance Moisturizing Gel

A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water

Start: Sep 2013Est. completion: Jan 2014422 patients
N/ACompleted
NCT02317172Innovation PharmaceuticalsGel-based artificial saliva

Efficacy of Novel Edible Gel-based Artificial Saliva in Thai Geriatric Populations With Systemic Diseases

Start: Oct 2012Est. completion: Mar 2013120 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.