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Xerostomia

3
Pipeline Programs
10
Companies
12
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
2
1
0
0
0
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Otsuka
OtsukaJapan - Tokushima
1 program
1
RebamipidePhase 21 trial
Active Trials
NCT00233363Completed104Est. Jan 2006
ViiV Healthcare
ViiV HealthcareNC - Durham
4 programs
1
MighTeaFlowPhase 1/2
Biotene mouthwashN/A
Biotene mouthwashN/A
Experimental Oralbalance Moisturizing GelN/A
Parion Sciences
Parion SciencesNC - Durham
1 program
1
P-552Phase 1/21 trial
Active Trials
NCT01369589Completed24Est. Apr 2011
GSK
GSKLONDON, United Kingdom
4 programs
Biotene mouthwashN/A1 trial
Biotene mouthwashN/A1 trial
Experimental Oralbalance Moisturizing GelN/A1 trial
MighTeaFlowPHASE_1_21 trial
Active Trials
NCT02641912Completed100Est. Apr 2016
NCT03005041Completed56Est. Oct 2016
NCT03494985Completed422Est. Jan 2014
+1 more trials
Solventum
SolventumMN - St. Paul
1 program
3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth SprayN/A1 trial
Active Trials
NCT04186806Completed40Est. Dec 2019
Helsinn
HelsinnIreland - Dublin
1 program
AqualiefN/A1 trial
Active Trials
NCT03601962Terminated100Est. Jan 2020
Innovation Pharmaceuticals
1 program
Gel-based artificial salivaN/A1 trial
Active Trials
NCT02317172Completed120Est. Mar 2013
Johnson & Johnson
Johnson & JohnsonNEW BRUNSWICK, NJ
1 program
Remineralizing Extreme Dry Mouth Spray with XylitolN/A1 trial
Active Trials
NCT04608773Completed129Est. Jun 2023
Jerusalem Pharmaceuticals
Jerusalem PharmaceuticalsIsrael - Ramallah
1 program
ElectrostimulationPHASE_41 trial
Active Trials
NCT00509808Completed200Est. Apr 2010
Camurus
CamurusSweden - Lund
1 program
XER2020PHASE_41 trial
Active Trials
NCT01316393Completed20Est. Jun 2011

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
CamurusXER2020
Jerusalem PharmaceuticalsElectrostimulation
OtsukaRebamipide
GSKMighTeaFlow
Parion SciencesP-552
Johnson & JohnsonRemineralizing Extreme Dry Mouth Spray with Xylitol
Solventum3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth Spray
HelsinnAqualief
GSKBiotene mouthwash
GSKBiotene mouthwash
GSKExperimental Oralbalance Moisturizing Gel
Innovation PharmaceuticalsGel-based artificial saliva

Clinical Trials (12)

Total enrollment: 1,375 patients across 12 trials

NCT01316393CamurusXER2020

Effects of Mucoprotective Product on Xerostomia

Start: Feb 2011Est. completion: Jun 201120 patients
Phase 4Completed
NCT00509808Jerusalem PharmaceuticalsElectrostimulation

Evaluation of an Electro-stimulator for the Treatment of Xerostomia

Start: Jan 2007Est. completion: Apr 2010200 patients
Phase 4Completed
NCT00233363OtsukaRebamipide

Exploratory Study for Dry Mouth in Patients With Sjögren's Syndrome

Start: Apr 2005Est. completion: Jan 2006104 patients
Phase 2Completed
NCT01647737GSKMighTeaFlow

Green Tea Lozenges for the Management of Dry Mouth

Start: Mar 2011Est. completion: Jun 201360 patients
Phase 1/2Completed
NCT01369589Parion SciencesP-552

An Evaluation of the Impact of a Single Dose of P-552 on Oral Mucosal Wetness

Start: Nov 2010Est. completion: Apr 201124 patients
Phase 1/2Completed
NCT04608773Johnson & JohnsonRemineralizing Extreme Dry Mouth Spray with Xylitol

Blinded Dry Mouth Spray Crossover Study

Start: Jan 2021Est. completion: Jun 2023129 patients
N/ACompleted
NCT04186806Solventum3M Dry Mouth Moisturizing Spray to Biotene Moisturizing Mouth Spray

Evaluation of the Efficacy of 3M Dry Mouth Moisturizing Spray

Start: Nov 2019Est. completion: Dec 201940 patients
N/ACompleted
NCT03601962HelsinnAqualief

Effects of Aqualief® in Patients With Xerostomia as Consequence of Radiotherapy for Head and Neck Cancer

Start: Jul 2017Est. completion: Jan 2020100 patients
N/ATerminated
NCT03005041GSKBiotene mouthwash

Consumer Perception of an Experimental Mouthwash After a Single Use in Dry Mouth Subjects

Start: Aug 2016Est. completion: Oct 201656 patients
N/ACompleted
NCT02641912GSKBiotene mouthwash

Potential of an Experimental Mouthwash Formulation to Reduce Dry Mouth Symptoms

Start: Mar 2016Est. completion: Apr 2016100 patients
N/ACompleted
NCT03494985GSKExperimental Oralbalance Moisturizing Gel

A Clinical Study to Evaluate the Efficacy of Three Dry Mouth Relief Products Versus Water

Start: Sep 2013Est. completion: Jan 2014422 patients
N/ACompleted
NCT02317172Innovation PharmaceuticalsGel-based artificial saliva

Efficacy of Novel Edible Gel-based Artificial Saliva in Thai Geriatric Populations With Systemic Diseases

Start: Oct 2012Est. completion: Mar 2013120 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

10 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.