Analgesia

14
Pipeline Programs
4
Companies
14
Clinical Trials
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
3
0
4
6
Early DiscoveryClinical DevelopmentMarket

On Market (2)

Approved therapies currently available

U
BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREEApproved
bupivacaine hydrochloride
Unknown Company
injection2013
U
XARACOLLApproved
bupivacaine hydrochloride
Unknown Company
implantation2020

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Heron Therapeutics
9 programs
3
2
4
Bupivacaine HClPhase 41 trial
Bupivacaine HydrochloridePhase 41 trial
Bupivacaine liposome injectable suspensionPhase 41 trial
HTX-011Phase 41 trial
HTX-011Phase 31 trial
+4 more programs
Active Trials
NCT02471898CompletedEst. Sep 2015
NCT03922048WithdrawnEst. Dec 2025
NCT03955211CompletedEst. Dec 2021
+6 more trials
Pfizer
PfizerNEW YORK, NY
2 programs
1
1
Ibuprofen 600 mg Immediate Release/Extended Release CapletPhase 31 trial
oxycodone hydrochloridePhase 11 trial
Active Trials
NCT01530542Completed35Est. Sep 2010
NCT01789606Completed1,083Est. Jun 2013
Humanwell Pharmaceutical
1 program
1
Remimazolam BesylatePhase 31 trial
Active Trials
NCT04947345UnknownEst. Sep 2022
City Therapeutics
City TherapeuticsMA - Cambridge
2 programs
Scalp blockN/A1 trial
control group; Patients who received physiological salineN/A1 trial
Active Trials
NCT06588751CompletedEst. Nov 2024
NCT06386575CompletedEst. Aug 2024

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
Heron TherapeuticsBupivacaine Hydrochloride
Heron TherapeuticsHTX-011
Heron TherapeuticsBupivacaine HCl
Heron TherapeuticsBupivacaine liposome injectable suspension
Humanwell PharmaceuticalRemimazolam Besylate
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
PfizerIbuprofen 600 mg Immediate Release/Extended Release Caplet
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
Pfizeroxycodone hydrochloride
City TherapeuticsScalp block
City Therapeuticscontrol group; Patients who received physiological saline

Clinical Trials (14)

Total enrollment: 1,118 patients across 14 trials

NCT05109312Heron TherapeuticsBupivacaine Hydrochloride

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

Start: Oct 2021Est. completion: Jun 2024
Phase 4Unknown
NCT06109428Heron TherapeuticsHTX-011

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE

Start: Oct 2021Est. completion: Apr 2022
Phase 4Completed
NCT03705065Heron TherapeuticsBupivacaine HCl

Bupivacaine HCl PK and Safety in Augmentation Mammoplasty

Start: Sep 2018Est. completion: Nov 2018
Phase 4Completed
NCT04102267Heron TherapeuticsBupivacaine liposome injectable suspension

Extended Delivery of Bupivacaine Study in Herniorrhaphy

Start: Jul 2018Est. completion: Oct 2018
Phase 4Completed
NCT04947345Humanwell PharmaceuticalRemimazolam Besylate

The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients

Start: Sep 2021Est. completion: Sep 2022
Phase 3Unknown
NCT03974932Heron TherapeuticsHTX-011

Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen

Start: Jun 2019Est. completion: Jan 2021
Phase 3Completed
NCT03907176Heron TherapeuticsHTX-011

Herniorrhaphy Study for Opioid Elimination

Start: Apr 2019Est. completion: Nov 2021
Phase 3Completed
NCT01789606PfizerIbuprofen 600 mg Immediate Release/Extended Release Caplet

Self-Selection and Actual Use Trial of Ibuprofen 600 mg Immediate Release/Extended Caplet

Start: Sep 2012Est. completion: Jun 20131,083 patients
Phase 3Completed
NCT03922048Heron TherapeuticsHTX-011

Pediatric Postoperative Analgesia Herniorrhaphy Study

Start: Jul 2023Est. completion: Dec 2025
Phase 2Withdrawn
NCT03955211Heron TherapeuticsHTX-011

HTX-011 Administration Study in Planned Caesarean Section Procedure

Start: Jun 2019Est. completion: Dec 2021
Phase 2Completed
NCT02471898Heron TherapeuticsHTX-011

A Phase 2, Two-Part Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy

Start: Jun 2015Est. completion: Sep 2015
Phase 2Completed
NCT01530542Pfizeroxycodone hydrochloride

A Clinical Study To Characterize The Pharmacokinetics And The Effects Of Food On Oxycodone In Healthy Volunteers

Start: Jul 2010Est. completion: Sep 201035 patients
Phase 1Completed
NCT06588751City TherapeuticsScalp block

Effects of SCALP Block on Postoperative Analgesia in Craniotomy Surgery

Start: Oct 2024Est. completion: Nov 2024
N/ACompleted
NCT06386575City Therapeuticscontrol group; Patients who received physiological saline

Suprainguinal Fascia Iliaca Block in Knee Arthroplasty

Start: Jun 2024Est. completion: Aug 2024
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

4 late-stage (Phase 3) programs — potential near-term approvals
4 companies competing in this space