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Analgesia

9
Pipeline Programs
11
Companies
20
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
2
1
3
1
Early DiscoveryClinical DevelopmentMarket

Competitive Landscape

11 companies ranked by most advanced pipeline stage

ViiV Healthcare
ViiV HealthcareNC - Durham
4 programs
1
1
1
SufentanilPhase 41 trial
RemifentanilPhase 31 trial
ParacetamolPhase 11 trial
RemifentanilN/A1 trial
Active Trials
NCT01299584Completed775Est. Apr 2010
NCT01568749Completed14Est. Aug 2009
NCT00436345Terminated39Est. Sep 2008
+1 more trials
Pfizer
PfizerNEW YORK, NY
2 programs
1
1
Ibuprofen 600 mg Immediate Release/Extended Release CapletPhase 31 trial
oxycodone hydrochloridePhase 11 trial
Active Trials
NCT01530542Completed35Est. Sep 2010
NCT01789606Completed1,083Est. Jun 2013
UNION therapeutics
UNION therapeuticsDenmark - Hellerup
1 program
1
Remimazolam BesylatePhase 31 trial
Active Trials
NCT04947345Unknown84Est. Sep 2022
Innovation Pharmaceuticals
1 program
1
F14Phase 2/31 trial
Active Trials
NCT04860635Suspended100Est. Jul 2028
Sharp Therapeutics
Sharp TherapeuticsPA - Pittsburgh
1 program
1
Org 28611Phase 2
MSD
MSDIreland - Ballydine
1 program
1
Org 28611Phase 2
Heron Therapeutics
9 programs
HTX-011PHASE_21 trial
HTX-011PHASE_21 trial
HTX-011PHASE_21 trial
HTX-011PHASE_31 trial
HTX-011PHASE_31 trial
+4 more programs
Active Trials
NCT03922048Withdrawn0Est. Dec 2025
NCT02471898Completed71Est. Sep 2015
NCT03955211Completed25Est. Dec 2021
+6 more trials
GSK
GSKLONDON, United Kingdom
4 programs
RemifentanilN/A
ParacetamolPHASE_1
RemifentanilPHASE_3
SufentanilPHASE_4
City Therapeutics
City TherapeuticsMA - Cambridge
2 programs
Scalp blockN/A1 trial
control group; Patients who received physiological salineN/A1 trial
Active Trials
NCT06588751CompletedEst. Nov 2024
NCT06386575CompletedEst. Aug 2024
Lundbeck
LundbeckDenmark - Copenhagen
1 program
Heat StimulationN/A1 trial
Active Trials
NCT06356376Unknown30Est. Apr 2024
Humanwell Pharmaceutical
1 program
Remimazolam BesylatePHASE_3

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
Heron TherapeuticsHTX-011
Heron TherapeuticsBupivacaine Hydrochloride
Heron TherapeuticsBupivacaine HCl
Heron TherapeuticsBupivacaine liposome injectable suspension
ViiV HealthcareSufentanil
UNION therapeuticsRemimazolam Besylate
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
PfizerIbuprofen 600 mg Immediate Release/Extended Release Caplet
ViiV HealthcareRemifentanil
Innovation PharmaceuticalsF14
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
Heron TherapeuticsHTX-011
Pfizeroxycodone hydrochloride

Showing 15 of 20 trials with date data

Clinical Trials (20)

Total enrollment: 2,927 patients across 20 trials

NCT06109428Heron TherapeuticsHTX-011

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE

Start: Oct 2021Est. completion: Apr 202230 patients
Phase 4Completed
NCT05109312Heron TherapeuticsBupivacaine Hydrochloride

A Multi-surgery Assessment of ZYNRELEF (HTX-011), AMAZE. Master Protocol HTX-011-401.

Start: Oct 2021Est. completion: Jun 202490 patients
Phase 4Unknown
NCT03705065Heron TherapeuticsBupivacaine HCl

Bupivacaine HCl PK and Safety in Augmentation Mammoplasty

Start: Sep 2018Est. completion: Nov 201830 patients
Phase 4Completed
NCT04102267Heron TherapeuticsBupivacaine liposome injectable suspension

Extended Delivery of Bupivacaine Study in Herniorrhaphy

Start: Jul 2018Est. completion: Oct 201832 patients
Phase 4Completed
NCT00421720ViiV HealthcareSufentanil

A Study Comparing Two Analgesia/Sedation Regimens, Remifentanil/Propofol Versus Sufentanil/Propofol In Mechanically Ventilated Intensive Care Patients Requiring Analgesia And Sedation.

Start: Jan 2007164 patients
Phase 4Terminated
NCT04947345UNION therapeuticsRemimazolam Besylate

The Availability and Safety Study of Remimazolam Besylate for Injection on Sedation of ERAS Patients

Start: Sep 2021Est. completion: Sep 202284 patients
Phase 3Unknown
NCT03974932Heron TherapeuticsHTX-011

Total Knee Arthroplasty (TKA) Study of HTX-011 in an Multimodal Analgesic Regimen (MMA) Regimen

Start: Jun 2019Est. completion: Jan 2021116 patients
Phase 3Completed
NCT03907176Heron TherapeuticsHTX-011

Study of Post-Herniorrhaphy Non-opioid MMA Regimens

Start: Apr 2019Est. completion: Nov 2021209 patients
Phase 3Completed
NCT01789606PfizerIbuprofen 600 mg Immediate Release/Extended Release Caplet

Self-Selection and Actual Use Trial of Ibuprofen 600 mg Immediate Release/Extended Caplet

Start: Sep 2012Est. completion: Jun 20131,083 patients
Phase 3Completed
NCT00436345ViiV HealthcareRemifentanil

Pharmacoeconomic Consequences Of Analgesia in the Intensive Care Unit (ICU)

Start: Nov 2007Est. completion: Sep 200839 patients
Phase 3Terminated
NCT04860635Innovation PharmaceuticalsF14

Safety of F14 Following Total Knee Replacement

Start: Jan 2027Est. completion: Jul 2028100 patients
Phase 2/3Suspended
NCT03922048Heron TherapeuticsHTX-011

Pediatric Postoperative Analgesia Herniorrhaphy Study

Start: Jul 2023Est. completion: Dec 20250
Phase 2Withdrawn
NCT03955211Heron TherapeuticsHTX-011

HTX-011 Administration Study in Planned Caesarean Section Procedure

Start: Jun 2019Est. completion: Dec 202125 patients
Phase 2Completed
NCT02471898Heron TherapeuticsHTX-011

A Phase 2, Two-Part Evaluation of the Efficacy and Safety of Locally Administered HTX-011 for Postoperative Analgesia Following Bunionectomy

Start: Jun 2015Est. completion: Sep 201571 patients
Phase 2Completed
NCT01530542Pfizeroxycodone hydrochloride

A Clinical Study To Characterize The Pharmacokinetics And The Effects Of Food On Oxycodone In Healthy Volunteers

Start: Jul 2010Est. completion: Sep 201035 patients
Phase 1Completed
NCT01568749ViiV HealthcareParacetamol

A Study Investigating the Pharmacokinetic Profiles of Four Extended Release Paracetamol Formulations

Start: Dec 2008Est. completion: Aug 200914 patients
Phase 1Completed
NCT06588751City TherapeuticsScalp block

Effects of SCALP Block on Postoperative Analgesia in Craniotomy Surgery

Start: Oct 2024Est. completion: Nov 2024
N/ACompleted
NCT06386575City Therapeuticscontrol group; Patients who received physiological saline

Suprainguinal Fascia Iliaca Block in Knee Arthroplasty

Start: Jun 2024Est. completion: Aug 2024
N/ACompleted
NCT06356376LundbeckHeat Stimulation

The Effects of Pain and Pain Relief on Peripheral Nerve Excitability

Start: Dec 2023Est. completion: Apr 202430 patients
N/AUnknown
NCT01299584ViiV HealthcareRemifentanil

ULTIVA Post Marketing Surveillance

Start: Sep 2005Est. completion: Apr 2010775 patients
N/ACompleted

Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

3 late-stage (Phase 3) programs, potential near-term approvals
11 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.