AMVUTTRA

PeakRNA

vutrisiran

NDASUBCUTANEOUSSOLUTION
Approved
Jun 2022
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
3

Mechanism of Action

double-stranded siRNA-GalNAc conjugate that causes degradation of mutant and wild-type TTR mRNA through RNA interference, which results in a reduction of serum TTR protein and TTR protein deposits in tissues.

Clinical Trials (3)

NCT06679946Phase 3Enrolling By Invitation

A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Started Dec 2024
700 enrolled
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
NCT04153149Phase 3Active Not Recruiting

HELIOS-B: A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy

Started Nov 2019
655 enrolled
Transthyretin Amyloidosis (ATTR) With Cardiomyopathy
NCT03759379Phase 3Completed

HELIOS-A: A Study of Vutrisiran (ALN-TTRSC02) in Patients With Hereditary Transthyretin Amyloidosis (hATTR Amyloidosis)

Started Feb 2019
164 enrolled
Amyloidosis, HereditaryTransthyretin Amyloidosis

Loss of Exclusivity

LOE Date
Jul 28, 2036
126 months away
Patent Expiry
Jul 28, 2036
Exclusivity Expiry
Jun 13, 2029

Patent Records (5)

Patent #ExpiryTypeUse Code
10131907
Aug 24, 2028
SubstanceProduct
U-3396
10806791
Dec 4, 2028
Substance
9370581
Dec 4, 2028
SubstanceProduct
U-3396
8828956
Dec 4, 2028
SubstanceProduct
U-3396
8106022
Dec 12, 2029
SubstanceProduct
U-3396