NDAORALCAPSULE
Approved
Dec 1967
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
5/8 — Partial
VIBRAMYCIN (doxycycline hyclate) by Pfizer is tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. Approved for gonorrhea, chlamydia, syphilis and 2 more indications. First approved in 1967.
Drug data last refreshed 19h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
VIBRAMYCIN (doxycycline hyclate) is a broad-spectrum tetracycline antibiotic that inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It is indicated for treatment of sexually transmitted infections (gonorrhea, chlamydia, syphilis), acne vulgaris, H. pylori infection, and other gram-positive and gram-negative bacterial infections. The drug is readily absorbed orally with peak serum levels achieved at 2 hours and exhibits bacteriostatic activity across a wide range of pathogens.
$0.771MPart D
LOE ApproachingAs a mature, off-patent product approaching loss of exclusivity, the brand team is likely small and focused on defending market share through generic differentiation and niche indication development.
Mechanism of Action
Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.