Psoriatic Arthritis

37
Pipeline Programs
19
Companies
50
Clinical Trials
8 recruiting
3
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
2
0
10
0
20
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1458%
Small Molecule
938%
Peptide
14%
+ 18 programs with unclassified modality

On Market (3)

Approved therapies currently available

UP
BIMZELXApproved
bimekizumab
UCB Pharma
injection2023
Novartis
COSENTYXApproved
secukinumab
Novartis
Interleukin-17A Antagonist [EPC]injection2023
Eli Lilly and Company
TALTZApproved
ixekizumab
Eli Lilly and Company
Interleukin-17A Antagonist [EPC]injection2016

Competitive Landscape

18 companies ranked by most advanced pipeline stage

UP
UCB PharmaBelgium - Brussels
8 programs
2
1
5
1
BimekizumabPhase 3Monoclonal Antibody1 trial
BimekizumabPhase 3Monoclonal Antibody1 trial
BimekizumabPhase 3Monoclonal Antibody1 trial
BimekizumabPhase 3Monoclonal Antibody1 trial
BimekizumabPhase 3Monoclonal Antibody1 trial
+3 more programs
Active Trials
NCT07290036Recruiting392Est. Jul 2028
NCT02141763Completed53Est. Aug 2015
NCT03347110Completed184Est. Oct 2020
+5 more trials
AbbVie
AbbVieNORTH CHICAGO, IL
4 programs
1
1
Upadacitinib 15 MG [Rinvoq]Phase 41 trial
LutikizumabPhase 2Monoclonal Antibody1 trial
Efficacy and Safety of Humira® in Patients With Psoriatic Arthritis in Normal Medical PracticeN/A
Special Investigation in Patients With Psoriatic Arthritis (PsA) (Working Productivity and Activity N/A1 trial
Active Trials
NCT02414633Completed148Est. Mar 2017
NCT06865105Recruiting120Est. Jan 2028
NCT06454188Recruiting100Est. Dec 2026
Novartis
NovartisBASEL, Switzerland
3 programs
1
2
1
AIN457 6 mg/kg i.v.Phase 31 trial
COSENTYX(Secukinumab)Phase 3Monoclonal Antibody5 trials
SecukinumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT02854163Completed30Est. Sep 2019
NCT04209205Completed381Est. May 2022
NCT07454889Not Yet Recruiting34Est. Mar 2027
+4 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
1 program
1
TALTZ(Ixekizumab)Phase 4Monoclonal Antibody5 trials
Active Trials
NCT07443956Not Yet Recruiting45Est. May 2030
NCT06857942Recruiting200Est. May 2028
NCT06864026Recruiting200Est. Nov 2027
+2 more trials
Pfizer
PfizerNEW YORK, NY
4 programs
2
Intensive management or Tight controlPhase 31 trial
Tofacitinib 5 mg BIDPhase 31 trial
Decision AidN/A1 trial
Study Evaluating Anxiety and Depression in Patients With Psoriatic ArthritisN/A1 trial
Active Trials
NCT03737045Completed37Est. Dec 2025
NCT00884468Completed384Est. Dec 2008
NCT01106079Completed206Est. Jan 2013
+1 more trials
Galapagos
Galapagos2800 MECHELEN, Belgium
4 programs
2
2
FilgotinibPhase 3Small Molecule
FilgotinibPhase 3Small Molecule
filgotinibPhase 2Small Molecule1 trial
filgotinibPhase 2Small Molecule1 trial
Active Trials
NCT03320876Terminated122Est. Jun 2021
NCT03101670Completed131Est. Mar 2018
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
3 programs
1
2
210 mg brodalumabPhase 3Monoclonal Antibody1 trial
210 mg brodalumabPhase 3Monoclonal Antibody1 trial
AMG 827 140Phase 21 trial
Active Trials
NCT01516957TerminatedEst. Sep 2015
NCT02029495TerminatedEst. Oct 2015
NCT02024646CompletedEst. Oct 2015
GS
Gilead SciencesFOSTER CITY, CA
3 programs
3
FilgotinibPhase 3Small Molecule
FilgotinibPhase 3Small Molecule1 trial
FilgotinibPhase 3Small Molecule1 trial
Active Trials
NCT04115839Terminated106Est. Mar 2021
NCT04115748Terminated67Est. May 2021
Amgen
AmgenTHOUSAND OAKS, CA
2 programs
1
Apremilast 20mgPhase 31 trial
Global gene expression profiles obtained from synovial biopsies.N/A1 trial
Active Trials
NCT04645420Completed19Est. Feb 2023
NCT01212770Completed505Est. Feb 2017
Takeda
TakedaTOKYO, Japan
2 programs
2
ZasocitinibPhase 3Small Molecule1 trial
ZasocitinibPhase 3Small Molecule1 trial
Active Trials
NCT06671483Recruiting1,088Est. Jan 2028
NCT06671496Recruiting600Est. Jan 2028
Abbott
AbbottABBOTT PARK, IL
1 program
1
AdalimumabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT00427362Completed127
Ventyx Biosciences
Ventyx BiosciencesSAN DIEGO, CA
1 program
1
Dose A VTX958Phase 21 trial
Active Trials
NCT05715125TerminatedEst. Jan 2024
Nimbus Therapeutics
1 program
1
NDI-034858Phase 2
CT
1 program
1
TQH3906 CapsulePhase 21 trial
Active Trials
NCT07406035Not Yet RecruitingEst. Nov 2027
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
1 program
1
liraglutidePhase 2Peptide1 trial
Active Trials
NCT02472717Withdrawn0Est. Oct 2016
Genesis Therapeutics
Genesis TherapeuticsCA - Burlingame
1 program
Apremilast in Psoriatic Arthritis in Real-life Clinical Practice in GreeceN/A
Verona Pharma
Verona PharmaUK - London
1 program
Fecal calprotectin assayN/A1 trial
Active Trials
NCT04190108CompletedEst. Oct 2019
Alliance Pharmaceuticals
1 program
adalimumabN/AMonoclonal Antibody1 trial
Active Trials
NCT03955861Completed80Est. Jul 2021

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Eli Lilly and CompanyIxekizumab
Eli Lilly and CompanyIxekizumab
AbbVieUpadacitinib 15 MG [Rinvoq]
NovartisSecukinumab
Eli Lilly and CompanyIxekizumab
NovartisSecukinumab
Eli Lilly and CompanyIxekizumab
NovartisSecukinumab
NovartisSecukinumab
NovartisSecukinumab
NovartisSecukinumab
Eli Lilly and CompanyIxekizumab
NovartisSecukinumab
Eli Lilly and CompanyIxekizumab
NovartisSecukinumab

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 15,132 patients across 50 trials

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Start: Mar 2025Est. completion: May 2028200 patients
Phase 4Recruiting

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Start: Mar 2025Est. completion: Nov 2027200 patients
Phase 4Recruiting
NCT06454188AbbVieUpadacitinib 15 MG [Rinvoq]

A Study to Evaluate the Impact of Upadacitinib on Spondyloarthritis Outcomes in Patients With Active Psoriatic Arthritis

Start: Nov 2024Est. completion: Dec 2026100 patients
Phase 4Recruiting

A Study Evaluating the Efficacy of Secukinumab 300mg in Chinese Adults With Active Ankylosing Spondylitis

Start: Jun 2024Est. completion: Aug 2026100 patients
Phase 4Recruiting

A Study of Ixekizumab (LY2439821) in Participants Aged ≥18 Years With Moderate-to-Severe Plaque or Active Psoriatic Arthritis in India

Start: Jun 2023Est. completion: Sep 2024250 patients
Phase 4Completed

A Study of Secukinumab to Evaluate Maintenance of Response in Participants With Non-radiographic Axial Spondyloarthritis Who Achieved Remission

Start: Mar 2023Est. completion: Jun 2028240 patients
Phase 4Active Not Recruiting

Ixekizumab for the Management of Refractory Non-Infectious Uveitis: A Proof-of-Concept Study

Start: Jun 2022Est. completion: Dec 202420 patients
Phase 4Unknown

Open Label Study of the Effects of Secukinumab on Nail Psoriasis and Non-Invasive Measures of Enthesitis (Phase IV)

Start: Feb 2022Est. completion: May 202516 patients
Phase 4Completed

Brain Changes in Psoriasis After Secukinumab Treatment

Start: Jun 2021Est. completion: Mar 202520 patients
Phase 4Completed

Secukinumab Open Label Roll-over Extension Protocol

Start: Dec 2020Est. completion: Apr 20301,000 patients
Phase 4Recruiting

An Efficacy Study of Secukinumab in Plaque Psoriasis Patients With Subclinical Psoriatic Arthritis as Measured by Musculoskeletal Ultrasound

Start: Nov 2020Est. completion: Mar 20210
Phase 4Withdrawn

A Study of Ixekizumab (LY2439821) in Participants in Japan With Generalized Pustular Psoriasis and Erythrodermic Psoriasis

Start: Jul 2019Est. completion: Jul 202012 patients
Phase 4Completed

Treat-to-target With Secukinumab in Axial Spondyloarthritis

Start: Jan 2019Est. completion: Feb 202188 patients
Phase 4Unknown

A Study of Ixekizumab (LY2439821) Compared to Guselkumab in Participants With Moderate-to-Severe Plaque Psoriasis

Start: Nov 2018Est. completion: Jan 20201,027 patients
Phase 4Completed

Study Estimating the Clinical Difference Between 300 mg and 150 mg of Secukinumab Following Dose Escalation to 300 mg in Patients With Ankylosing Spondylitis

Start: Mar 2018Est. completion: May 2021322 patients
Phase 4Completed

Comparison of Secukinumab 300 mg Combined With a Lifestyle Intervention to Secukinumab Alone for the Treatment of Moderate to Severe Psoriasis Patients With Concomitant Metabolic Syndrome

Start: Feb 2018Est. completion: Jun 2022781 patients
Phase 4Completed

Secukinumab Therapy for the Treatment of Moderate to Severe Plaque Psoriasis With Response Monitoring Using Optical Coherence Tomography (OCT).

Start: Dec 2017Est. completion: Dec 202130 patients
Phase 4Unknown

A Study of Ixekizumab (LY2439821) Versus Adalimumab in Participants With Psoriatic Arthritis

Start: Aug 2017Est. completion: Sep 2019566 patients
Phase 4Completed

Study of the Efficacy of Early Intervention With Secukinumab 300 mg s.c. Compared to Narrow-band UVB in Patients With New-onset Moderate to Severe Plaque Psoriasis

Start: Mar 2017Est. completion: Jun 2023196 patients
Phase 4Completed

Secukinumab in Active Non-segmental Vitiligo

Start: Oct 2016Est. completion: Feb 20198 patients
Phase 4Completed

Immunologic Response to Secukinumab in Plaque Psoriasis

Start: Oct 2016Est. completion: Dec 201815 patients
Phase 4Completed

Study to Evaluate the Safety and Efficacy of Secukinumab 300 mg and 150 mg in Adult Patients With Active Psoriatic Arthritis (PsA) After 16 Weeks of Treatment Compared to Placebo

Start: Jun 2016Est. completion: Dec 2018258 patients
Phase 4Completed

A Study to Evaluate Clear Skin Effect on Quality of Life in Patients With Plaque Psoriasis.

Start: Mar 2016Est. completion: Mar 20181,660 patients
Phase 4Completed

Study to Evaluate the Effect of Secukinumab Compared to Placebo on Aortic Vascular Inflammation in Subjects With Moderate to Severe Plaque Psoriasis

Start: Feb 2016Est. completion: Feb 201891 patients
Phase 4Completed

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

Start: Mar 2025Est. completion: Jan 2028600 patients
Phase 3Recruiting

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have Not Taken Biologic Medicines

Start: Mar 2025Est. completion: Jan 20281,088 patients
Phase 3Recruiting

A Study to Evaluate the Efficacy and Safety of Bimekizumab in Adult Study Participants With Active Psoriatic Arthritis

Start: Oct 2024Est. completion: May 2026684 patients
Phase 3Active Not Recruiting

Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight

Start: Sep 2024Est. completion: May 2026250 patients
Phase 3Active Not Recruiting

Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Psoriatic Arthritis and Obesity or Overweight

Start: Sep 2024Est. completion: Apr 2026279 patients
Phase 3Active Not Recruiting

Open-label, Long-term Safety Study of Secukinumab in Polymyalgia Rheumatica (PMR)

Start: Jun 2024Est. completion: Aug 2028288 patients
Phase 3Recruiting

Study of Efficacy and Safety of Secukinumab in Participants With Moderate-severe Rotator Cuff Tendinopathy

Start: Aug 2023Est. completion: Dec 202433 patients
Phase 3Terminated

Study of Efficacy and Safety of Secukinumab in Participants With Moderate-severe Rotator Cuff Tendinopathy

Start: Aug 2023Est. completion: Dec 202460 patients
Phase 3Terminated

Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Polymyalgia Rheumatica (PMR)

Start: Mar 2023Est. completion: Feb 2026381 patients
Phase 3Completed

Efficacy and Safety of Secukinumab in Patients With New Onset of Giant Cell Arteritis Who Are in Clinical Remission

Start: Sep 2022Est. completion: Feb 2026151 patients
Phase 3Completed

Open-label Extension Study of Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Lupus Nephritis

Start: Aug 2022Est. completion: Aug 202331 patients
Phase 3Terminated

Study to Demonstrate the Efficacy and Safety of Secukinumab up to 224 Weeks in Subjects With Active Peripheral Spondyloarthritis (pSpA).

Start: Aug 2022Est. completion: Jun 20280
Phase 3Withdrawn

A Study of the Efficacy and Safety of Secukinumab 300 mg in Patients With Thyroid Eye Disease (TED)

Start: Nov 2021Est. completion: May 202328 patients
Phase 3Terminated

Phase III Study of Efficacy and Safety of Secukinumab Versus Placebo, in Combination With Glucocorticoid Taper Regimen, in Patients With Giant Cell Arteritis (GCA)

Start: Oct 2021Est. completion: Feb 2026355 patients
Phase 3Completed

Efficacy and Safety Study of Secukinumab in Chinese Participants With Non-radiographic Axial Spondyloarthritis

Start: Jul 2021Est. completion: Feb 2025137 patients
Phase 3Completed

A Study of Ixekizumab (LY2439821) in Children With Juvenile Idiopathic Arthritis Categories of Enthesitis-related Arthritis (Including Juvenile Onset Ankylosing Spondylitis) and Juvenile Psoriatic Arthritis

Start: Apr 2021Est. completion: Apr 2028101 patients
Phase 3Active Not Recruiting

Efficacy of Secukinumab Compared to Ustekinumab in Adults With Active Psoriatic Arthritis and Failure of TNFα-Inhibitor Treatment

Start: Dec 2020Est. completion: Oct 2024119 patients
Phase 3Completed

Study of Safety, Efficacy and Tolerability of Secukinumab Versus Placebo, in Combination With SoC Therapy, in Patients With Active Lupus Nephritis

Start: Jul 2020Est. completion: Sep 2023275 patients
Phase 3Terminated

A Study of Ixekizumab (LY2439821) in Chinese Participants With Radiographic Axial Spondyloarthritis

Start: Apr 2020Est. completion: Mar 2022147 patients
Phase 3Completed

Extension Study to Assess Effects of Non-interrupted Versus Interrupted and Long Term Treatment of Two Dose Regimes of Secukinumab in Subjects With Hidradenitis Suppurativa

Start: Mar 2020Est. completion: Jul 2026703 patients
Phase 3Active Not Recruiting

A Study of Secukinumab Treatment in Patients With Plaque Psoriasis and Coexisting Non-alcoholic Fatty Liver Disease (NAFLD)

Start: Feb 2020Est. completion: Jul 202110 patients
Phase 3Terminated
NCT04209205NovartisAIN457 6 mg/kg i.v.

Study to Demonstrate the Efficacy, Safety and Tolerability of Intravenous Secukinumab up to 52 Weeks in Subjects With Active Psoriatic Arthritis

Start: Jan 2020Est. completion: May 2022381 patients
Phase 3Completed

Study to Demonstrate the Efficacy, Safety and Tolerability of an Intravenous Regimen of Secukinumab Compared to Placebo in Subjects With Active axSpA

Start: Dec 2019Est. completion: Dec 2022527 patients
Phase 3Completed

Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Psoriatic Arthritis Who Are Naive to Biologic DMARD Therapy

Start: Dec 2019Est. completion: May 202167 patients
Phase 3Terminated

Study to Evaluate the Efficacy and Safety of Filgotinib in Participants With Active Psoriatic Arthritis Who Have an Inadequate Response or Are Intolerant to Biologic DMARD Therapy

Start: Nov 2019Est. completion: Mar 2021106 patients
Phase 3Terminated

A Study to Assess the Long-term Safety, Tolerability, and Efficacy of Bimekizumab in the Treatment of Subjects With Active Psoriatic Arthritis

Start: Aug 2019Est. completion: May 20261,131 patients
Phase 3Active Not Recruiting

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

20 late-stage (Phase 3) programs — potential near-term approvals
8 actively recruiting trials targeting 15,132 patients
19 companies competing in this space