Alopecia Areata

Dermatology
13
Pipeline Programs
10
Companies
16
Clinical Trials
2 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
8
1
1
2
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
660%
Small Molecule
440%
+ 7 programs with unclassified modality

On Market (2)

Approved therapies currently available

U
BARICITINIBApproved
baricitinib
Unknown Company
oral2024
U
OLUMIANTApproved
baricitinib
Unknown Company
oral2025

Competitive Landscape

10 companies ranked by most advanced pipeline stage

Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
2 programs
1
1
BaricitinibPhase 3Small Molecule1 trial
BaricitinibPhase 2/3Small Molecule1 trial
Active Trials
NCT03570749Completed764Est. Jan 2025
NCT03899259Completed546Est. Nov 2024
Regeneron
RegeneronTARRYTOWN, NY
2 programs
2
DupilumabPhase 2Monoclonal Antibody1 trial
DupilumabPhase 2Monoclonal Antibody
Active Trials
NCT05551793Recruiting68Est. Nov 2027
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
DaxdilimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT05368103Completed30Est. Jan 2024
Sanofi
SanofiPARIS, France
1 program
1
DupilumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT03359356Completed60Est. Dec 2020
Nektar Therapeutics
Nektar TherapeuticsSAN FRANCISCO, CA
1 program
1
RezpegaldesleukinPhase 21 trial
Active Trials
NCT06340360Active Not RecruitingEst. Aug 2026
AnaptysBio
AnaptysBioSAN DIEGO, CA
1 program
1
RosnilimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT05205070UnknownEst. Mar 2023
Novartis
NovartisBASEL, Switzerland
1 program
1
SecukinumabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT02599129Terminated11Est. Nov 2016
Q32 Bio
Q32 BioMA - Waltham
1 program
1
bempikibartPhase 21 trial
Active Trials
NCT06018428Active Not Recruiting75Est. Sep 2026
Pfizer
PfizerNEW YORK, NY
6 programs
1
Ritlecitinib 20 mgPhase 11 trial
Exposure of interestN/A1 trial
LITFULON/A1 trial
Quantification of the Socio-economic Multifacet Burden of Alopecia Areata and Identification of the N/A1 trial
RitlecitinibN/ASmall Molecule1 trial
+1 more programs
Active Trials
NCT04239521Completed51,955Est. Nov 2022
NCT06279221Active Not Recruiting487Est. Apr 2030
NCT05588310Unknown150Est. Apr 2025
+3 more trials
Alliance Pharmaceuticals
1 program
tSVF by lipoaspirationN/A1 trial
Active Trials
NCT03078686Unknown60Est. Jun 2025

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
Eli Lilly and CompanyBaricitinib
Eli Lilly and CompanyBaricitinib
Nektar TherapeuticsRezpegaldesleukin
Q32 Biobempikibart
RegeneronDupilumab
AmgenDaxdilimab
AnaptysBioRosnilimab
SanofiDupilumab
NovartisSecukinumab
PfizerRitlecitinib 20 mg
PfizerRitlecitinib
PfizerRitlecitinib
PfizerLITFULO
PfizerQuantification of the Socio-economic Multifacet Burden of Alopecia Areata and Identification of the
PfizerExposure of interest

Showing 15 of 16 trials with date data

Clinical Trials (16)

Total enrollment: 55,371 patients across 16 trials

A Study of Baricitinib (LY3009104) in Adults With Severe or Very Severe Alopecia Areata

Start: Jul 2019Est. completion: Nov 2024546 patients
Phase 3Completed

A Study of Baricitinib (LY3009104) in Participants With Severe or Very Severe Alopecia Areata

Start: Sep 2018Est. completion: Jan 2025764 patients
Phase 2/3Completed

A Phase 2b Study to Evaluate Rezpegaldesleukin (Rezpeg) in the Treatment of Severe to Very Severe Alopecia Areata in Adult Patients (Rezolve AA)

Start: Apr 2024Est. completion: Aug 2026
Phase 2Active Not Recruiting

A Phase 2a Proof-of-Concept Trial of Bempikibart (ADX-914) for the Treatment of Severe Alopecia Areata (SIGNAL-AA)

Start: Sep 2023Est. completion: Sep 202675 patients
Phase 2Active Not Recruiting

Regeneron AA Multicenter (Dupilumab)

Start: Apr 2023Est. completion: Nov 202768 patients
Phase 2Recruiting

Study of DAXDILIMAB for the Treatment of Moderate-to-Severe Alopecia Areata

Start: Apr 2022Est. completion: Jan 202430 patients
Phase 2Completed

A Study to Evaluate the Efficacy and Safety of Rosnilimab (ANB030) in Treatment of Subjects With Moderate-to-Severe Alopecia Areata

Start: Dec 2021Est. completion: Mar 2023
Phase 2Unknown

Treatment of Alopecia Areata (AA) With Dupilumab in Patients With and Without Atopic Dermatitis (AD)

Start: Jan 2018Est. completion: Dec 202060 patients
Phase 2Completed

A Study of Secukinumab for the Treatment of Alopecia Areata

Start: Nov 2015Est. completion: Nov 201611 patients
Phase 2Terminated
NCT05650333PfizerRitlecitinib 20 mg

A Study to Learn About the Study Medicine (Called Ritlecitinib) For the Potential Treatment of Severe Alopecia Areata (AA) In Children 6 To Less Than 12 Years of Age

Start: Mar 2023Est. completion: Aug 202315 patients
Phase 1Completed
NCT07226531PfizerRitlecitinib

Utilization and Effectiveness of Ritlecitinib in a Real-World Population With Severe AA in the US

Start: Feb 2026Est. completion: Mar 2026300 patients
N/ANot Yet Recruiting
NCT06531109PfizerRitlecitinib

Characterization And Clinical Outcomes of AA Patients Treated With Ritlecitinib

Start: Aug 2024Est. completion: Mar 2028850 patients
N/ARecruiting

Litfulo Capsules Special Investigation

Start: Mar 2024Est. completion: Apr 2030487 patients
N/AActive Not Recruiting
NCT05588310PfizerQuantification of the Socio-economic Multifacet Burden of Alopecia Areata and Identification of the

Quantification of the Socio-economic Multifacet Burden of Alopecia Areata and Identification of the Associated Factors

Start: Nov 2022Est. completion: Apr 2025150 patients
N/AUnknown
NCT04239521PfizerExposure of interest

The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata

Start: Oct 2020Est. completion: Nov 202251,955 patients
N/ACompleted

Biocellular-Cellular Regenerative Treatment Scaring Alopecia and Alopecia Areata

Start: Feb 2017Est. completion: Jun 202560 patients
N/AUnknown

Related Jobs in Dermatology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
2 actively recruiting trials targeting 55,371 patients
10 companies competing in this space