ATRIDOX
LOE Approachingdoxycycline hyclate
NDAPERIODONTALSYSTEM, EXTENDED RELEASE
Approved
Sep 1998
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Mechanism of Action
Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral…
Indications (13)
the following infections: Rocky Mountain spotted fevertyphus feverthe typhus groupQ feverrickettsialpoxtick fevers caused by Rickettsiaeinfections caused by the following gram-negative microorganisms: Chancroid caused by Haemophilus ducreyiinfections caused by the following gram-negative bacteriabacteriologic testing indicates appropriate susceptibility to the drug: Escherichia coliinfections caused by the following gram-positive microorganismsmalaria due to Plasmodium falciparum in short-term travelers (< 4 months) to areas with chloroquine and/or pyrimethamine-sulfadoxine resistant strainsincidenceprogression of disease following exposure to aerosolized Bacillus anthracis