NDAPERIODONTALSYSTEM, EXTENDED RELEASE
Approved
Sep 1998
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
ATRIDOX (doxycycline hyclate) by Pfizer is tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. Approved for acne vulgaris, gonorrhea, chlamydia and 2 more indications. First approved in 1998.
Drug data last refreshed 20h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ATRIDOX is a periodontal extended-release doxycycline hyclate system approved in 1998 for treatment of acne vulgaris, gonorrhea, chlamydia, syphilis, and other sexually transmitted infections. It works by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit, providing bacteriostatic activity against a broad range of gram-positive and gram-negative bacteria. The drug is readily absorbed orally with peak serum levels at 2 hours and a half-life of 18-22 hours regardless of renal function.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30%), indicating a mature asset with contracting commercial opportunity and likely smaller team size.
Mechanism of Action
Tetracyclines are readily absorbed and are bound to plasma proteins in varying degree. They are concentrated by the liver in the bile, and excreted in the urine and feces at high concentrations and in a biologically active form. Doxycycline is virtually completely absorbed after oral…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.