Relapsing Multiple Sclerosis

Neurology
22
Pipeline Programs
13
Companies
34
Clinical Trials
11 recruiting
2
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
3
2
2
12
3
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
563%
Small Molecule
225%
Cell Therapy
113%
+ 16 programs with unclassified modality

On Market (2)

Approved therapies currently available

U
BRIUMVIApproved
ublituximab
Unknown Company
CD20-directed Cytolytic Antibody [EPC]intravenous2022
Biogen
PLEGRIDYApproved
peginterferon beta-1a
Biogen
Interferon beta [EPC]injection2014

Competitive Landscape

13 companies ranked by most advanced pipeline stage

Biogen
BiogenCAMBRIDGE, MA
5 programs
1
3
1
BIIB017Phase 31 trial
BIIB017Phase 31 trial
peginterferon beta-1aPhase 35 trials
CDP323Phase 1/2
natalizumabN/AMonoclonal Antibody1 trial
Active Trials
NCT01070836Completed35,895Est. Nov 2015
NCT01939002Completed251Est. Nov 2015
NCT00906399Completed1,516Est. Oct 2013
+5 more trials
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
1 program
1
Dimethyl Fumarate Enteric-coated CapsulesPhase 41 trial
Active Trials
NCT07138833Not Yet RecruitingEst. Aug 2028
M&
Merck & Co.RAHWAY, NJ
5 programs
1
3
Rebif New Formulation + prophylactic IbuprofenPhase 3Small Molecule1 trial
TeriflunomidePhase 31 trial
TeriflunomidePhase 31 trial
Atacicept 25 mgPhase 21 trial
RebifN/A1 trial
Active Trials
NCT01601119CompletedEst. Jul 2014
NCT00853762TerminatedEst. Feb 2011
NCT00619307CompletedEst. Apr 2008
+2 more trials
TG Therapeutics
TG TherapeuticsNEW YORK, NY
3 programs
1
2
UblituximabPhase 3Monoclonal Antibody1 trial
UblituximabPhase 3Monoclonal Antibody1 trial
UblituximabPhase 2/3Monoclonal Antibody1 trial
Active Trials
NCT07220252Not Yet Recruiting240Est. Jun 2033
NCT07211633Recruiting360Est. Dec 2028
NCT05877963Recruiting800Est. Dec 2027
Teva
TevaIsrael - Petach Tikva
2 programs
2
LaquinimodPhase 31 trial
LaquinimodPhase 31 trial
Active Trials
NCT00988052Terminated839Est. Jul 2017
NCT01047319Terminated1,047Est. Jun 2017
Sandoz
SandozAustria - Kundl
1 program
1
CYB704Phase 31 trial
Active Trials
NCT06847724RecruitingEst. Oct 2029
Roche
RocheSTAVANGER NORWAY, Norway
1 program
1
FenebrutinibPhase 3Small Molecule3 trials
Active Trials
NCT07161258Recruiting12Est. Feb 2029
NCT04586010Active Not Recruiting746Est. Nov 2027
NCT03596632Completed8Est. Aug 2018
Clene
CleneSALT LAKE CITY, UT
1 program
1
CNM-Au8Phase 2/31 trial
Active Trials
NCT04626921CompletedEst. Sep 2023
Zenas BioPharma
Zenas BioPharmaWALTHAM, MA
1 program
1
ObexelimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT06564311Active Not Recruiting93Est. Feb 2026
UP
UCB PharmaBelgium - Brussels
1 program
1
CDP323Phase 1/21 trial
Active Trials
NCT00726648Completed71Est. Mar 2009
Novartis
NovartisBASEL, Switzerland
1 program
1
rapcabtagene autoleucelPhase 1/2Cell Therapy5 trials
Active Trials
NCT07443137Not Yet Recruiting20Est. Aug 2028
NCT07048197Recruiting27Est. Nov 2028
NCT06868290Recruiting126Est. May 2030
+2 more trials
Providence Therapeutics
1 program
Cerebrospinal and Blood Serum Semaphorin 4A LevelsN/A
Bristol Myers Squibb
1 program
Cerebrospinal and Blood Serum Semaphorin 4A LevelsN/A1 trial
Active Trials
NCT05077956Withdrawn0Est. Oct 2023

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Qilu PharmaceuticalDimethyl Fumarate Enteric-coated Capsules
Biogenpeginterferon beta-1a
TG TherapeuticsUblituximab
SandozCYB704
TG TherapeuticsUblituximab
RocheFenebrutinib
Merck & Co.Teriflunomide
Merck & Co.Teriflunomide
Biogenpeginterferon beta-1a
BiogenBIIB017
Biogenpeginterferon beta-1a
TevaLaquinimod
TevaLaquinimod
BiogenBIIB017
Merck & Co.Rebif New Formulation + prophylactic Ibuprofen

Showing 15 of 34 trials with date data

Clinical Trials (34)

Total enrollment: 46,410 patients across 34 trials

NCT07138833Qilu PharmaceuticalDimethyl Fumarate Enteric-coated Capsules

A Phase IV Study of Dimethyl Fumarate Enteric-coated Capsules for Relapsing Multiple Sclerosis (RMS)

Start: Sep 2025Est. completion: Aug 2028
Phase 4Not Yet Recruiting
NCT02234869Biogenpeginterferon beta-1a

Transition to Peginterferon Beta-1a (BIIB017) From Subcutaneous Interferon Therapy

Start: Oct 2014Est. completion: Mar 20180
Phase 4Withdrawn

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, Radiological and Clinical Effects of Subcutaneous Ublituximab in Participants With Relapsing Multiple Sclerosis (RMS)

Start: Jul 2025Est. completion: Dec 2028360 patients
Phase 3Recruiting

Comparative PK, PD, Efficacy, and Safety Assessment of the Proposed Ocrelizumab Biosimilar CYB704 and Ocrevus in Participants With Relapsing Multiple Sclerosis

Start: Jun 2025Est. completion: Oct 2029
Phase 3Recruiting

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

Start: Jun 2023Est. completion: Dec 2027800 patients
Phase 3Recruiting
NCT04586010RocheFenebrutinib

A Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared With Teriflunomide in Relapsing Multiple Sclerosis (RMS)

Start: Mar 2021Est. completion: Nov 2027746 patients
Phase 3Active Not Recruiting

Study of Evobrutinib in Participants With RMS (evolutionRMS 2)

Start: Jul 2020Est. completion: Mar 2024
Phase 3Terminated

Study of Evobrutinib in Participants With RMS (evolutionRMS 1)

Start: Jun 2020Est. completion: Mar 20241,124 patients
Phase 3Terminated
NCT03958877Biogenpeginterferon beta-1a

A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis

Start: Oct 2019Est. completion: May 2027152 patients
Phase 3Active Not Recruiting

Characterize Flu-like Symptoms in Relapsing Multiple Sclerosis Patients Transitioning From Non-Pegylated Interferon Beta (IFN-β) Therapies to Peginterferon Beta-1a (BIIB017)

Start: Nov 2013Est. completion: Nov 2015251 patients
Phase 3Completed
NCT01332019Biogenpeginterferon beta-1a

Long-Term Safety and Efficacy Study of Peginterferon Beta-1a

Start: Apr 2011Est. completion: Oct 20151,077 patients
Phase 3Completed
NCT01047319TevaLaquinimod

A Study to Evaluate the Long-term Safety, Tolerability and Effect of Daily Oral Laquinimod 0.6 mg on Disease Course in Subjects With Relapsing Multiple Sclerosis

Start: May 2010Est. completion: Jun 20171,047 patients
Phase 3Terminated
NCT00988052TevaLaquinimod

A Study To Evaluate the Long-Term Safety, Tolerability and Effect on Disease Course

Start: Nov 2009Est. completion: Jul 2017839 patients
Phase 3Terminated

Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis

Start: Jun 2009Est. completion: Oct 20131,516 patients
Phase 3Completed
NCT00619307Merck & Co.Rebif New Formulation + prophylactic Ibuprofen

Transition to Rebif New Formulation

Start: Jul 2007Est. completion: Apr 2008
Phase 3Completed

Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis

Start: Mar 2026Est. completion: Jun 2033240 patients
Phase 2/3Not Yet Recruiting

A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis

Start: Oct 2020Est. completion: Sep 2023
Phase 2/3Completed
NCT07161258RocheFenebrutinib

A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)

Start: Oct 2025Est. completion: Feb 202912 patients
Phase 2Recruiting
NCT06868290Novartisrapcabtagene autoleucel

Phase 2 Study Evaluating Rapcabtagene Autoleucel in Participants With Severe Active GPA or MPA

Start: Mar 2025Est. completion: May 2030126 patients
Phase 2Recruiting
NCT06665256Novartisrapcabtagene autoleucel

Phase 2 Study of Rapcabtagene Autoleucel in Myositis

Start: Dec 2024Est. completion: Jul 2030123 patients
Phase 2Recruiting
NCT06581198Novartisrapcabtagene autoleucel

A Study of Rapcabtagene Autoleucel in Active, Refractory Systemic Lupus Erythematosus (SLE) or Lupus Nephritis (LN) Patients (AUTOGRAPH - SLE/LN)

Start: Sep 2024Est. completion: Feb 2032179 patients
Phase 2Recruiting

A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)

Start: Aug 2024Est. completion: Feb 202693 patients
Phase 2Active Not Recruiting
NCT00853762Merck & Co.Atacicept 25 mg

Atacicept in Multiple Sclerosis Extension Study, Phase II

Start: Mar 2009Est. completion: Feb 2011
Phase 2Terminated
NCT07048197Novartisrapcabtagene autoleucel

A Study to Assess Safety, Cellular Kinetics and Exploratory Efficacy of Rapcabtagene Autoleucel in Rheumatoid Arthritis and Sjogren's Disease

Start: Jun 2025Est. completion: Nov 202827 patients
Phase 1/2Recruiting
NCT06617793Novartisrapcabtagene autoleucel

An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple Sclerosis

Start: Feb 2025Est. completion: Oct 203028 patients
Phase 1/2Recruiting
NCT06675864Novartisrapcabtagene autoleucel

Open-label, Multi-center, Phase I/II Study to Assess Safety, Disease Progression and Cellular Kinetics Following YTB323 Administration in Participants With Non-active Progressive Multiple Sclerosis (PMS)

Start: Dec 2024Est. completion: Jun 203028 patients
Phase 1/2Recruiting

CDP323 Biomarker Study

Start: Jul 2008Est. completion: Mar 200971 patients
Phase 1/2Completed
NCT07443137Novartisrapcabtagene autoleucel

CAR-T ceLL for Eradication of Active Residual Disease in LBCL (CLEAR-1 Study)

Start: May 2026Est. completion: Aug 202820 patients
Phase 1Not Yet Recruiting
NCT03596632RocheFenebrutinib

Study Investigating a Single Oral Dose of Fenebrutinib in Healthy Volunteers

Start: Jul 2018Est. completion: Aug 20188 patients
Phase 1Completed
NCT05077956Bristol Myers SquibbCerebrospinal and Blood Serum Semaphorin 4A Levels

Sema 4A as a Marker for Inflammatory Disease in Multiple Sclerosis

Start: Oct 2021Est. completion: Oct 20230
N/AWithdrawn
NCT05688436Biogenpeginterferon beta-1a

A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies

Start: Sep 2021Est. completion: Jan 20311,178 patients
N/ARecruiting
NCT04655222Biogenpeginterferon beta-1a

Study to Investigate Pregnancy Outcomes in Female Participants Exposed to Subcutaneous (SC) Peginterferon Beta-1a and Intramuscular (IM) Interferon Beta-1a Reported in a German Participant Support Program

Start: Apr 2021Est. completion: Oct 2021470 patients
N/ACompleted

Impact of Disease Modifying Therapies (DMTs) and Associated Support Services in Relapsing Multiple Sclerosis (RMS) Patients

Start: Jan 2012Est. completion: Jul 2014
N/ACompleted

JC Virus Antibody Study of Participants With Relapsing Forms of MS Receiving Treatment With Natalizumab

Start: Mar 2010Est. completion: Nov 201535,895 patients
N/ACompleted

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

12 late-stage (Phase 3) programs — potential near-term approvals
11 actively recruiting trials targeting 46,410 patients
13 companies competing in this space