Skip to main content

Relapsing Multiple Sclerosis

Neurology
18
Pipeline Programs
17
Companies
50
Clinical Trials
7 recruiting
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
1
2
0
10
5
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1869%
Small Molecule
519%
Cell Therapy
28%
Vaccine
14%
+ 23 programs with unclassified modality

Neurology is a $26.9B market dominated by a single blockbuster anticoagulant (ELIQUIS), representing a mature but consolidating therapeutic area.

$26.9B marketMature→ Stable30 products15 companies

Key Trends

  • Extreme market concentration: 68% of spending driven by one FXa inhibitor product
  • Psychiatric and migraine therapies emerging as secondary growth drivers
  • High clinical trial activity (8,279 trials) signals continued pipeline development

Career Verdict

Neurology offers solid career stability with good hiring demand, but limited upside growth—best suited for professionals seeking established market positions rather than emerging-area innovation.

AI-generated market analysis based on FDA, CMS, ClinicalTrials.gov, and hiring data

Market Leaders

#1ELIQUISStable
$18.3B
Bristol Myers Squibb·Launch14.9yr
$1.8B
#3BRILINTAStable
$692M
AstraZeneca·Peak10.1yr
#4NUPLAZIDStable
$596M
$530M
Johnson & Johnson·Peak15.4yr

Drug Class Breakdown

FXa Inhibitors (anticoagulant)
$18.3B(68%)

market-defining single product

Dopamine/Serotonin Antagonists (psychiatric)
$2.4B(9%)

stable mature class

P2Y12 Receptor Antagonists (antiplatelet)
$692M(3%)

niche but stable

5-HT2A Inverse Agonists (psychiatric)
$596M(2%)

specialty indication focus

CGRP Receptor Antagonists (migraine)
$931M(3%)

emerging growth segment

Immunomodulators (MS)
$747M(3%)

stable with LOE risk

Other mechanisms
$2.6B(10%)

diverse small products

Career Outlook

Stable

Neurology represents a mature, cash-generative market with limited growth tailwinds but strong hiring stability. The dominance of ELIQUIS creates a bifurcated career landscape: high-opportunity positions in emerging segments (CGRP antagonists, psychiatric therapeutics) and commoditized roles in anticoagulant franchises. Job availability is solid but growth expectations should be tempered relative to oncology or immunology.

Breaking In

Entry-level professionals should target clinical operations or commercial support roles at J&J, AstraZeneca, or Sanofi to build domain expertise in neurology disease states and competitive dynamics.

For Experienced Professionals

Experienced professionals should prioritize emerging mechanism roles (CGRP, tau-targeting programs) or pivot to medtech/neurotech (Stryker, Medtronic) to capture higher growth and salary potential than traditional pharma incumbents.

In-Demand Skills

Medical Science Liaisons (MSL) for specialist engagementClinical trial operations expertisePsychiatric/neurodegenerative disease educationRegulatory affairs (given patent cliff activity)Commercial strategy around branded/generic transitions

Best For

Medical Science LiaisonCommercial Brand Manager (anticoagulant/psychiatric franchises)Clinical Operations ManagerRegulatory Affairs SpecialistClinical Development Manager (CGRP/immunomodulator pipelines)

Hiring Landscape

$100K-$199K

Neurology shows moderate but distributed hiring across pharma and medtech employers, with 4,186 total jobs listed. Commercial functions lead (947 roles, $169K avg), followed by clinical operations (467 roles, $132K avg), indicating bias toward commercialization over R&D. Takeda leads external hiring (762 jobs) with strong representation in contract research and CRO spaces.

4,186
Open Roles
5
Companies Hiring
5
Departments

Top Hiring Companies

762Growing
434Stable
302Stable

By Department

Commercial(23%)
$169K
Clinical Operations(11%)
$132K
Engineering(8%)
$199K
IT(4%)
$100K
Manufacturing(3%)
$170K

Commercial and clinical operations roles dominate, offering stable mid-career positions; engineering roles command premium salaries ($199K), suggesting strong device/neurotech hiring pockets.

Competitive Landscape

16 companies ranked by most advanced pipeline stage

Sandoz
SandozAustria - Kundl
23 programs
1
1
10
4
FingolimodPhase 41 trial
OfatumumabPhase 4Monoclonal Antibody1 trial
OfatumumabPhase 4Monoclonal Antibody1 trial
Quadrivalent influenza vaccinePhase 4Vaccine1 trial
FTY720Phase 31 trial
+18 more programs
Active Trials
NCT04847596Completed25Est. Feb 2022
NCT05776888Active Not Recruiting106Est. Aug 2026
NCT05266469Completed168Est. Nov 2024
+21 more trials
Colorado Therapeutics
Colorado TherapeuticsCO - Louisville
1 program
1
OzanimodPhase 41 trial
Active Trials
NCT06529406Recruiting100Est. Aug 2029
Genentech
GenentechCA - Oceanside
1 program
1
FenebrutinibPhase 2Small Molecule1 trial
Active Trials
NCT07161258Recruiting12Est. Feb 2029
Merck & Co.
Merck & Co.RAHWAY, NJ
5 programs
RebifN/A1 trial
Atacicept 25 mgPHASE_21 trial
Rebif New Formulation + prophylactic IbuprofenPHASE_3Small Molecule1 trial
TeriflunomidePHASE_31 trial
TeriflunomidePHASE_31 trial
Active Trials
NCT01601119Completed545Est. Jul 2014
NCT00853762Terminated74Est. Feb 2011
NCT00619307Completed117Est. Apr 2008
+2 more trials
Biogen
BiogenCAMBRIDGE, MA
5 programs
natalizumabN/AMonoclonal Antibody1 trial
CDP323PHASE_1_2
BIIB017PHASE_31 trial
BIIB017PHASE_31 trial
peginterferon beta-1aPHASE_35 trials
Active Trials
NCT01070836Completed35,895Est. Nov 2015
NCT00906399Completed1,516Est. Oct 2013
NCT01939002Completed251Est. Nov 2015
+5 more trials
TG Therapeutics
TG TherapeuticsNEW YORK, NY
3 programs
UblituximabPHASE_2_3Monoclonal Antibody1 trial
UblituximabPHASE_3Monoclonal Antibody1 trial
UblituximabPHASE_3Monoclonal Antibody1 trial
Active Trials
NCT07220252Not Yet Recruiting240Est. Jun 2033
NCT05877963Recruiting800Est. Dec 2027
NCT07211633Active Not Recruiting360Est. Dec 2028
Teva
TevaIsrael - Petach Tikva
2 programs
LaquinimodPHASE_34 trials
LaquinimodPHASE_31 trial
Active Trials
NCT02284568Completed374Est. Oct 2017
NCT02085863Completed40Est. Nov 2014
NCT01404117Withdrawn0Est. Jan 2014
+2 more trials
Bristol Myers Squibb
1 program
Cerebrospinal and Blood Serum Semaphorin 4A LevelsN/A1 trial
Active Trials
NCT05077956Withdrawn0Est. Oct 2023
Providence Therapeutics
1 program
Cerebrospinal and Blood Serum Semaphorin 4A LevelsN/A
Cinnagen
CinnagenIran - Tehran
1 program
Glatiramer AcetateN/A1 trial
Active Trials
NCT04928313Completed368Est. Feb 2020
UCB Pharma
UCB PharmaBelgium - Brussels
1 program
CDP323PHASE_1_21 trial
Active Trials
NCT00726648Completed71Est. Mar 2009
Novartis
NovartisBASEL, Switzerland
1 program
rapcabtagene autoleucelPHASE_1_2Cell Therapy
Zenas BioPharma
Zenas BioPharmaWALTHAM, MA
1 program
ObexelimabPHASE_2Monoclonal Antibody1 trial
Active Trials
NCT06564311Active Not Recruiting93Est. Feb 2026
Clene
CleneSALT LAKE CITY, UT
1 program
CNM-Au8PHASE_2_31 trial
Active Trials
NCT04626921Completed55Est. Sep 2023
Roche
RocheSTAVANGER NORWAY, Norway
1 program
FenebrutinibPHASE_3Small Molecule
Qilu Pharmaceutical
Qilu PharmaceuticalChina - Jinan
1 program
Dimethyl Fumarate Enteric-coated CapsulesPHASE_41 trial
Active Trials
NCT07138833Not Yet Recruiting50Est. Aug 2028

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
2030
2031
Qilu PharmaceuticalDimethyl Fumarate Enteric-coated Capsules
Colorado TherapeuticsOzanimod
SandozOfatumumab
SandozOfatumumab
SandozQuadrivalent influenza vaccine
SandozFingolimod
Biogenpeginterferon beta-1a
SandozRemibrutinib oral treatment
TG TherapeuticsUblituximab
SandozCYB704
TG TherapeuticsUblituximab
SandozRemibrutinib
SandozRemibrutinib
SandozOfatumumab
SandozOfatumumab

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 22,322 patients across 50 trials

NCT07138833Qilu PharmaceuticalDimethyl Fumarate Enteric-coated Capsules

A Phase IV Study of Dimethyl Fumarate Enteric-coated Capsules for Relapsing Multiple Sclerosis (RMS)

Start: Sep 2025Est. completion: Aug 202850 patients
Phase 4Not Yet Recruiting

Prospective Evaluation of Sequencing From antiCD-20 Therapies to Ozanimod

Start: Jul 2024Est. completion: Aug 2029100 patients
Phase 4Recruiting

Study of Efficacy and Safety of Ofatumumab in Relapsing Multiple Sclerosis (RMS) Patients in China

Start: Jul 2022Est. completion: Feb 202599 patients
Phase 4Completed

Exploring the Immune Response to SARS-CoV-2 COVID-19 Vaccines in Patients With Relapsing Multiple Sclerosis (RMS) Treated With Ofatumumab

Start: May 2021Est. completion: Jun 202334 patients
Phase 4Completed
NCT04667117SandozQuadrivalent influenza vaccine

A Multicenter Study to Assess Response to Influenza Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab

Start: Jan 2021Est. completion: Jul 202363 patients
Phase 4Completed

A Study of Immune Phenotype Biomarkers in Patients With Relapsing Multiple Sclerosis (RMS) After Treatment With 0.5mg Fingolimod

Start: Sep 2017Est. completion: Jun 2019382 patients
Phase 4Completed
NCT02234869Biogenpeginterferon beta-1a

Transition to Peginterferon Beta-1a (BIIB017) From Subcutaneous Interferon Therapy

Start: Oct 2014Est. completion: Mar 20180
Phase 4Withdrawn
NCT06846281SandozRemibrutinib oral treatment

Efficacy and Safety of Remibrutinib After Switching From Ocrelizumab in Participants Living With Relapsing Multiple Sclerosis.

Start: Jul 2025Est. completion: Jun 2031360 patients
Phase 3Recruiting

A Study to Evaluate the Pharmacokinetics, Pharmacodynamics, Safety, Radiological and Clinical Effects of Subcutaneous Ublituximab in Participants With Relapsing Multiple Sclerosis (RMS)

Start: Jul 2025Est. completion: Dec 2028360 patients
Phase 3Active Not Recruiting

Comparative PK, PD, Efficacy, and Safety Assessment of the Proposed Ocrelizumab Biosimilar CYB704 and Ocrevus in Participants With Relapsing Multiple Sclerosis

Start: Jun 2025Est. completion: May 2027183 patients
Phase 3Active Not Recruiting

Study to Evaluate Safety, Efficacy and Pharmacokinetics (PK) of a Modified Regimen of Ublituximab

Start: Jun 2023Est. completion: Dec 2027800 patients
Phase 3Recruiting
NCT05147220SandozRemibrutinib

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Start: Dec 2021Est. completion: Oct 20301,000 patients
Phase 3Active Not Recruiting
NCT05156281SandozRemibrutinib

Efficacy and Safety of Remibrutinib Compared to Teriflunomide in Participants With Relapsing Multiple Sclerosis (RMS)

Start: Dec 2021Est. completion: Oct 20301,007 patients
Phase 3Active Not Recruiting

A Single Arm Study Evaluating the Efficacy, Safety and Tolerability of Ofatumumab in Patients With Relapsing Multiple Sclerosis

Start: Oct 2020Est. completion: Oct 2024111 patients
Phase 3Completed

9-month Study to Assess the Efficacy of Ofatumumab on Microglia in Patients With Relapsing Forms of Multiple Sclerosis

Start: Sep 2020Est. completion: Dec 202210 patients
Phase 3Completed

An Open-label Study Evaluating Ofatumumab Treatment Effectiveness and PROs in Subjects With RMS Transitioning From Fumarate-based RMS Approved Therapies or Fingolimod to Ofatumumab

Start: Jul 2020Est. completion: Mar 2025562 patients
Phase 3Completed

Study of Evobrutinib in Participants With RMS (evolutionRMS 2)

Start: Jul 2020Est. completion: Mar 20241,166 patients
Phase 3Terminated

Study of Evobrutinib in Participants With RMS (evolutionRMS 1)

Start: Jun 2020Est. completion: Mar 20241,124 patients
Phase 3Terminated
NCT03958877Biogenpeginterferon beta-1a

A Study to Evaluate the Safety, Tolerability, and Efficacy of BIIB017 (Peginterferon Beta-1a) in Pediatric Participants for the Treatment of Relapsing-Remitting Multiple Sclerosis

Start: Oct 2019Est. completion: May 2027152 patients
Phase 3Active Not Recruiting

Long-term Safety, Tolerability and Effectiveness Study of Ofatumumab in Patients With Relapsing MS

Start: Dec 2018Est. completion: Sep 20281,882 patients
Phase 3Active Not Recruiting
NCT02792218SandozOfatumumab subcutaneous injection

Efficacy and Safety of Ofatumumab Compared to Teriflunomide in Patients With Relapsing Multiple Sclerosis

Start: Sep 2016Est. completion: Jul 2020930 patients
Phase 3Completed

Characterize Flu-like Symptoms in Relapsing Multiple Sclerosis Patients Transitioning From Non-Pegylated Interferon Beta (IFN-β) Therapies to Peginterferon Beta-1a (BIIB017)

Start: Nov 2013Est. completion: Nov 2015251 patients
Phase 3Completed
NCT01332019Biogenpeginterferon beta-1a

Long-Term Safety and Efficacy Study of Peginterferon Beta-1a

Start: Apr 2011Est. completion: Oct 20151,077 patients
Phase 3Completed

Effect of Treatment With Fingolimod on the Immune Response Following Seasonal Flu Vaccination and Tetanus Booster Injection in Patients With Relapsing Multiple Sclerosis (MS)

Start: Aug 2010Est. completion: May 2011138 patients
Phase 3Completed
NCT01047319TevaLaquinimod

A Study to Evaluate the Long-term Safety, Tolerability and Effect of Daily Oral Laquinimod 0.6 mg on Disease Course in Subjects With Relapsing Multiple Sclerosis

Start: May 2010Est. completion: Jun 20171,047 patients
Phase 3Terminated

Tolerability and Safety and Health Outcomes in Relapsing Multiple Sclerosis (MS) Patients

Start: May 2010Est. completion: Oct 20112,417 patients
Phase 3Completed
NCT00988052TevaLaquinimod

A Study To Evaluate the Long-Term Safety, Tolerability and Effect on Disease Course

Start: Nov 2009Est. completion: Jul 2017839 patients
Phase 3Terminated

Efficacy and Safety Study of Peginterferon Beta-1a in Participants With Relapsing Multiple Sclerosis

Start: Jun 2009Est. completion: Oct 20131,516 patients
Phase 3Completed
NCT00619307Merck & Co.Rebif New Formulation + prophylactic Ibuprofen

Transition to Rebif New Formulation

Start: Jul 2007Est. completion: Apr 2008117 patients
Phase 3Completed

Study to Assess Effects of Ublituximab in Pediatric Participants With Relapsing Forms of Multiple Sclerosis

Start: Jun 2026Est. completion: Jun 2033240 patients
Phase 2/3Not Yet Recruiting

A Multi-Center, Open-Label Long-Term Extension Study of CNM-Au8 In Patients With Stable Relapsing Multiple Sclerosis

Start: Oct 2020Est. completion: Sep 202355 patients
Phase 2/3Completed

A Pharmacokinetics (PK), Pharmacodynamics (PD), Safety and Tolerability Study of Fenebrutinib in Children and Adolescents With Relapsing Multiple Sclerosis (RMS)

Start: Oct 2025Est. completion: Feb 202912 patients
Phase 2Recruiting

A Study of Obexelimab in Patients With Relapsing Multiple Sclerosis (MoonStone)

Start: Aug 2024Est. completion: Feb 202693 patients
Phase 2Active Not Recruiting

Efficacy and Safety of Ofatumumab Compared to Placebo in Patients With Relapsing Multiple Sclerosis Followed by Extended Treatment With Open-label Ofatumumab

Start: Mar 2018Est. completion: Jul 202064 patients
Phase 2Completed
NCT02284568TevaLaquinimod

A Phase 2 Clinical Study in Subjects With Primary Progressive Multiple Sclerosis to Assess the Efficacy, Safety and Tolerability of Two Oral Doses of Laquinimod Either of 0.6 mg/Day or 1.5mg/Day (Experimental Drug) as Compared to Placebo

Start: Jan 2015Est. completion: Oct 2017374 patients
Phase 2Completed
NCT01404117TevaLaquinimod

A Multinational, Randomized, Double-blind, Parallel-group, Placebo-controlled Study Assessing the Safety and Tolerability

Start: Mar 2012Est. completion: Jan 20140
Phase 2Withdrawn
NCT00853762Merck & Co.Atacicept 25 mg

Atacicept in Multiple Sclerosis Extension Study, Phase II

Start: Mar 2009Est. completion: Feb 201174 patients
Phase 2Terminated
NCT06617793Sandozrapcabtagene autoleucel

An Open-label Study to Assess the Safety, Efficacy, and Cellular Kinetics of YTB323 in Relapsing Multiple Sclerosis

Start: Feb 2025Est. completion: Oct 203028 patients
Phase 1/2Recruiting

CDP323 Biomarker Study

Start: Jul 2008Est. completion: Mar 200971 patients
Phase 1/2Completed
NCT02085863TevaLaquinimod

A Phase I Study in Young Healthy Women to Investigate the Effects of Laquinimod on Standard Oral Contraceptive When Both Treatments Are Given Together

Start: Feb 2014Est. completion: Nov 201440 patients
Phase 1Completed
NCT07642557SandozRemibrutinib

Remibrutinib in Real-world Clinical Practice - a Germany Sub-study (REASSERT)

Start: Jul 2026Est. completion: May 2029470 patients
N/ANot Yet Recruiting

Ofatumumab in Portuguese Multiple Sclerosis Patients - an Observational Study

Start: Nov 2023Est. completion: Sep 2026174 patients
N/ARecruiting

Early Versus Late Ofatumumab (Kesimpta®) Use in Austrian RMS-Patients Over 2 Years

Start: Jul 2023Est. completion: Aug 2026106 patients
N/AActive Not Recruiting

Characterizing the Use of Ofatumumab in a Real World Setting

Start: Dec 2022Est. completion: Feb 2026103 patients
N/ACompleted

Exploring the Profiles of RMS Patients on Ofatumumab or Ocrelizumab in a Real-World Setting in the Gulf

Start: Jul 2022Est. completion: Nov 2024168 patients
N/ACompleted

A NIS Evaluating Various Injectable and Oral Treatments in Patients With Relapsing Multiple Sclerosis

Start: May 2022Est. completion: May 2029800 patients
N/ARecruiting
NCT05077956Bristol Myers SquibbCerebrospinal and Blood Serum Semaphorin 4A Levels

Sema 4A as a Marker for Inflammatory Disease in Multiple Sclerosis

Start: Oct 2021Est. completion: Oct 20230
N/AWithdrawn
NCT05688436Biogenpeginterferon beta-1a

A Study to Learn More About The Safety of Diroximel Fumarate (VUMERITY®) in Participants Who Took it During Pregnancy And About the Health of Their Babies

Start: Sep 2021Est. completion: Jan 20311,178 patients
N/AActive Not Recruiting

A Multicenter Study to Assess Response to COVID-19 Vaccine in Multiple Sclerosis Participants Treated With Ofatumumab

Start: May 2021Est. completion: Feb 202225 patients
N/ACompleted
NCT04655222Biogenpeginterferon beta-1a

Study to Investigate Pregnancy Outcomes in Female Participants Exposed to Subcutaneous (SC) Peginterferon Beta-1a and Intramuscular (IM) Interferon Beta-1a Reported in a German Participant Support Program

Start: Apr 2021Est. completion: Oct 2021470 patients
N/ACompleted

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

10 late-stage (Phase 3) programs, potential near-term approvals
7 actively recruiting trials targeting 22,322 patients
17 companies competing in this space

The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.