Partial Onset Seizures

Neurology
4
Pipeline Programs
2
Companies
7
Clinical Trials
1
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
0
1
2
Early DiscoveryClinical DevelopmentMarket

On Market (1)

Approved therapies currently available

U
PERAMPANELApproved
perampanel
Unknown Company
Noncompetitive AMPA Glutamate Receptor Antagonist [EPC]oral2025

Competitive Landscape

2 companies ranked by most advanced pipeline stage

E
EisaiChina - Liaoning
6 programs
1
1
PerampanelPhase 41 trial
E2007Phase 31 trial
Eslicarbazepine Acetate tabletsN/A1 trial
PerampanelN/A1 trial
PerampanelN/A1 trial
+1 more programs
Active Trials
NCT01830400Completed254Est. Jun 2014
NCT03836924Completed200Est. Mar 2020
NCT01871233No Longer Available
+3 more trials
Novartis
NovartisBASEL, Switzerland
1 program
1
BGG492Phase 21 trial
Active Trials
NCT01338805Completed56Est. Jul 2012

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
EisaiPerampanel
EisaiE2007
NovartisBGG492
EisaiPerampanel
EisaiEslicarbazepine Acetate tablets
EisaiZonisamide tablets

Clinical Trials (7)

Total enrollment: 759 patients across 7 trials

Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With Primary Generalized Tonic-Clonic Seizures

Start: Aug 2017Est. completion: Apr 202154 patients
Phase 4Completed

Study for Verification of Efficacy and Safety for Perampanel Monotherapy in Untreated Participants With Partial Onset Seizures (Including Secondarily Generalized Seizures (FREEDOM Study)

Start: Jun 2017Est. completion: Jul 202091 patients
Phase 3Completed

Phase II BGG492 Capsule Extension for Partial Epilepsy

Start: Jun 2011Est. completion: Jul 201256 patients
Phase 2Completed

An Extended Access Program for Perampanel

N/ANo Longer Available

A Study to Assess Safety and Efficacy of Perampanel in Indian Participants as an Adjunctive Treatment in Partial Onset Seizures With or Without Secondary Generalized Seizures in Participants With Epilepsy Aged 12 Years or Older

Start: Feb 2019Est. completion: Mar 2020200 patients
N/ACompleted
NCT01830400EisaiEslicarbazepine Acetate tablets

A Post-marketing Study Evaluating Eslicarbazepine Acetate (ESL) as Adjunctive Treatment in Partial-Onset Seizures (Study E2093-E044-404) (EPOS)

Start: Apr 2012Est. completion: Jun 2014254 patients
N/ACompleted
NCT01830868EisaiZonisamide tablets

A Post-marketing Observational Study Of The Use Of Zonisamide (ZNS) in the Adjunctive Treatment Of Adult Patients With Partial Onset Seizures (Study E2090-E044-410) (ZOOM)

Start: Mar 2012Est. completion: Aug 2013104 patients
N/ACompleted

Related Jobs in Neurology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
2 companies competing in this space