Osteoporosis

44
Pipeline Programs
23
Companies
50
Clinical Trials
5
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
8
1
4
0
14
17
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Peptide
758%
Monoclonal Antibody
433%
Small Molecule
18%
+ 50 programs with unclassified modality

On Market (5)

Approved therapies currently available

U
BILDYOSApproved
denosumab
Unknown Company
RANK Ligand Inhibitor [EPC]injection2025
U
BILPREVDAApproved
denosumab
Unknown Company
RANK Ligand Inhibitor [EPC]injection2025
Eli Lilly and Company
FORTEOApproved
teriparatide
Eli Lilly and Company
Parathyroid Hormone Analog [EPC]subcutaneous2002
U
NATPARAApproved
parathyroid hormone
Unknown Company
Parathyroid Hormone [EPC]injection2015
Radius Health
TYMLOSApproved
abaloparatide
Radius Health
Parathyroid Hormone-Related Peptide Analog [EPC]subcutaneous2017

Competitive Landscape

20 companies ranked by most advanced pipeline stage

Amgen
AmgenTHOUSAND OAKS, CA
9 programs
1
1
2
3
DMAB Discontinuation and SwitchingPhase 41 trial
ProliaPhase 41 trial
TetracyclinePhase 4Small Molecule1 trial
AlendronatePhase 31 trial
alendronatePhase 31 trial
+4 more programs
Active Trials
NCT00512499Completed1,410Est. Jul 2016
NCT00986895Completed32Est. Jun 2007
NCT00359047Unknown2,830Est. Dec 2025
+7 more trials
Eli Lilly and Company
Eli Lilly and CompanyINDIANAPOLIS, IN
8 programs
1
2
TeriparatidePhase 4Peptide1 trial
teriparatidePhase 4Peptide1 trial
TeriparatidePhase 3Peptide1 trial
Control groupN/A
DocumentationN/A
+3 more programs
Active Trials
NCT01155245Unknown60Est. Jan 2025
NCT01109472Completed1,009Est. Nov 2012
NCT00503399Completed92Est. Oct 2010
+2 more trials
Sanofi
SanofiPARIS, France
6 programs
2
1
1
ActonelPhase 41 trial
risedronatePhase 31 trial
RisedronatePhase 11 trial
risedronate DRPhase 11 trial
Awareness to Osteopenia's Treatment by Bisphosphonate in Male Suffering From Prostate CancerN/A1 trial
+1 more programs
Active Trials
NCT00816452Completed180Est. Jul 2010
NCT00837746Completed29Est. Oct 2006
NCT00699777Completed96Est. Apr 2008
+3 more trials
Novartis
NovartisBASEL, Switzerland
5 programs
2
1
Hormone replacement therapyPhase 4
AAE581Phase 21 trial
AAE581Phase 21 trial
Control groupN/A
DocumentationN/A
Active Trials
NCT00170911Completed160
NCT00100607Completed676Est. Sep 2005
Radius Health
Radius HealthMA - Boston
4 programs
1
1
1
1
AbaloparatidePhase 4Peptide1 trial
AbaloparatidePhase 3Peptide1 trial
teriparatidePhase 2Peptide1 trial
abaloparatide-sMTSPhase 11 trial
Active Trials
NCT04936984CompletedEst. Aug 2021
NCT00542425CompletedEst. Jun 2009
NCT03512262CompletedEst. Sep 2021
+1 more trials
E
EisaiChina - Liaoning
3 programs
1
2
MENATETRANONEPhase 41 trial
MenatetrenonePhase 41 trial
phylloquinonePhase 31 trial
Active Trials
NCT00062595Completed375Est. Oct 2004
NCT00165607Completed
NCT00548509Completed131Est. Jan 2013
Novo Nordisk
Novo NordiskBAGSVAERD DENMARK, Denmark
2 programs
1
Hormone replacement therapyPhase 41 trial
Study of Male Osteoporosis and AgingN/A1 trial
Active Trials
NCT00463411Unknown30,000Est. Dec 2017
NCT00252408Completed2,000Est. Dec 2003
GS
Gilead SciencesFOSTER CITY, CA
1 program
1
tenofovir-alafenamide-emtricitabinePhase 41 trial
Active Trials
NCT02815566Completed34Est. Feb 2021
Takeda
TakedaTOKYO, Japan
6 programs
4
ALX1-11Phase 31 trial
ALX1-11Phase 31 trial
PTH/CalciumPhase 31 trial
Parathyroid HormonePhase 32 trials
Sodium RisedronateN/A1 trial
+1 more programs
Active Trials
NCT02089997Completed3,304Est. Apr 2016
NCT02106442Completed579Est. Apr 2018
NCT00172120Completed91Est. Oct 2006
+4 more trials
Abbott
AbbottABBOTT PARK, IL
2 programs
1
1
AlendronatePhase 31 trial
FructooligosaccharidePhase 1/21 trial
Active Trials
NCT01005927Completed26Est. Jun 2009
NCT00236002Terminated182Est. Aug 2009
DS
Daiichi SankyoChina - Shanghai
1 program
1
DenosumabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT00680953Completed1,262Est. Jul 2012
CP
Chugai PharmaJapan - Tokyo
1 program
1
ED-71Phase 31 trial
Active Trials
NCT00144456Completed1,056Est. Oct 2008
UP
UCB PharmaBelgium - Brussels
1 program
1
RomosozumabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT05067335Completed327Est. Nov 2023
M&
Merck & Co.RAHWAY, NJ
7 programs
2
MK 0773Phase 11 trial
odanacatibPhase 11 trial
Control groupN/A
DocumentationN/A
Falls, Fractures & Osteoporosis Risk Assessment & ManagementN/A
+2 more programs
Active Trials
NCT01998737Completed1,011Est. Mar 2016
NCT01476150Unknown10,000Est. Mar 2014
NCT01011725Completed67Est. Mar 2009
+1 more trials
HM
Haoma MedicaUK - London
1 program
1
NaQuinatePhase 11 trial
Active Trials
NCT04036617UnknownEst. May 2020
T-Therapeutics
T-TherapeuticsUK - Cambridge
1 program
1
TK006Phase 11 trial
Active Trials
NCT03242512UnknownEst. Dec 2018
Pfizer
PfizerNEW YORK, NY
1 program
BazedoxifeneN/A5 trials
Active Trials
NCT02602704Completed114Est. Dec 2018
NCT02090400Completed110Est. Jul 2015
NCT01634789Terminated2Est. Nov 2012
+2 more trials
Bayer
BayerLEVERKUSEN, Germany
1 program
Osteoporosis and HaemophiliaN/A1 trial
Active Trials
NCT04524481Unknown250Est. Mar 2023
Stada
StadaBosnia & Herzegovina - Banja Luka
1 program
Study and Follow-up of the Clinical Effectiveness and Comparative Safety of Biosimilar Teriparatide N/APeptide1 trial
Active Trials
NCT05369013UnknownEst. Apr 2024
AB
AP BiosciencesTaiwan - Taipei
1 program
Study of Male Osteoporosis and AgingN/A

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
AmgenProlia
AmgenDMAB Discontinuation and Switching
Radius HealthAbaloparatide
Gilead Sciencestenofovir-alafenamide-emtricitabine
PfizerBazedoxifene
AmgenTetracycline
PfizerBazedoxifene
Eli Lilly and Companyteriparatide
Eli Lilly and CompanyTeriparatide
SanofiActonel
EisaiMenatetrenone
EisaiMENATETRANONE
Novo NordiskHormone replacement therapy
UCB PharmaRomosozumab
Radius HealthAbaloparatide

Showing 15 of 50 trials with date data

Clinical Trials (50)

Total enrollment: 12,884 patients across 50 trials

Evaluation of Efficacy and Safety of Prolia in Subjects of Male Osteoporosis in Mainland China

Start: Aug 2024Est. completion: Jan 2027102 patients
Phase 4Active Not Recruiting
NCT04177940AmgenDMAB Discontinuation and Switching

Denosumab (DMAB) Discontinuation and Switching in Glucocorticoid-Induced Osteoporosis (GIOP): a Pilot Study

Start: Aug 2020Est. completion: Aug 202545 patients
Phase 4Active Not Recruiting

Abaloparatide Before Total Knee Arthroplasty

Start: Jan 2020Est. completion: Apr 2025
Phase 4Completed
NCT02815566Gilead Sciencestenofovir-alafenamide-emtricitabine

Bone Health in Aging HIV Infected Women

Start: Sep 2017Est. completion: Feb 202134 patients
Phase 4Completed
NCT02602704PfizerBazedoxifene

Effectiveness of Bazedoxifene for Prevention of Glucocorticoid-induced Bone Loss in RA Patients

Start: Dec 2015Est. completion: Dec 2018114 patients
Phase 4Completed
NCT02576652AmgenTetracycline

Bone Histomorphometry in Postmenopausal Men and Women With Osteoarthritis Undergoing Total Hip Replacement

Start: Dec 2015Est. completion: Dec 20176 patients
Phase 4Completed
NCT02090400PfizerBazedoxifene

Switching From Oral Bisphosphonates to Bazedoxifene to Evaluate Effects on Bone Mineral Density in Postmenopausal Women

Start: May 2013Est. completion: Jul 2015110 patients
Phase 4Completed

Fracture (FX) Improvement With Teriparatide: FiX-IT Study

Start: Dec 2012Est. completion: Sep 201613 patients
Phase 4Completed

A Study That Will Compare the Effect of Two Drugs on Participants With Low Bone Mass and a Recent Hip Fracture

Start: Apr 2009Est. completion: Aug 2015224 patients
Phase 4Completed

Impact of Vertebral Fracture Knowledge on Persistence in Subjects Taking Glucocorticoid Therapy

Start: Jul 2002Est. completion: Dec 2004248 patients
Phase 4Completed
NCT00548509EisaiMenatetrenone

The Effect of Vitamin K2 on Bone Turnover

Start: Feb 2002Est. completion: Jan 2013131 patients
Phase 4Completed
NCT00165607EisaiMENATETRANONE

Randomized, Open, Parallel, Active Controlled Study on Fracture Prevention in Antiosteoporosis Treatment (OF Study)

Start: Apr 1996
Phase 4Completed
NCT00252408Novo NordiskHormone replacement therapy

Danish Osteoporosis Prevention Study

Start: Oct 1990Est. completion: Dec 20032,000 patients
Phase 4Completed

A Study to Test the Efficacy, Safety and Tolerability of Romosozumab Treatment in Postmenopausal Chinese Women With Osteoporosis

Start: Oct 2021Est. completion: Nov 2023327 patients
Phase 3Completed

Safety and Efficacy of Abaloparatide-SC in Men With Osteoporosis (ATOM)

Start: May 2018Est. completion: Sep 2021
Phase 3Completed

Denosumab Fracture Intervention Randomized Placebo Controlled Trial in Japanese Patients With Osteoporosis

Start: May 2008Est. completion: Jul 20121,262 patients
Phase 3Completed
NCT00518531Amgenalendronate

Denosumab Adherence Preference Satisfaction Study

Start: Sep 2007Est. completion: Jun 2010250 patients
Phase 3Completed

Comparison of the Effects of 2 Drugs on Lumbar Spine Volumetric BMD in Men With Glucocorticoid-Induced Osteoporosis

Start: Jul 2007Est. completion: Oct 201092 patients
Phase 3Completed
NCT00365456TakedaParathyroid Hormone

Sequential Treatment of Postmenopausal Women With Primary Osteoporosis (FP-001-IM)

Start: Jul 2006Est. completion: Aug 2011407 patients
Phase 3Completed
NCT00330460AmgenAlendronate

A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density.

Start: May 2006Est. completion: Jan 20081,189 patients
Phase 3Completed
NCT00384072PfizerBazedoxifene

Study Evaluating the Safety and Efficacy of Bazedoxifene in Postmenopausal Asian Women

Start: May 2006Est. completion: Sep 2007500 patients
Phase 3Completed
NCT00234819PfizerBazedoxifene

Study Evaluating Bazedoxifene/Conjugated Estrogen Combinations in Symptoms Associated With Menopause

Start: Oct 2005Est. completion: Feb 2007325 patients
Phase 3Completed

Cancer and Osteoporosis Research With Alendronate and Lupron (C.O.R.A.L )

Start: Jul 2005Est. completion: Aug 2009182 patients
Phase 3Terminated

Open Label Extension

Start: Jan 2005Est. completion: Oct 200691 patients
Phase 3Completed

A New Active Vitamin D, ED-71 for Osteoporosis

Start: Sep 2004Est. completion: Oct 20081,056 patients
Phase 3Completed

Calcium Supplementation in Postmenopausal Women

Start: Jan 2004Est. completion: Mar 2005374 patients
Phase 3Completed

Open Label Extension Study of PREOS

Start: Oct 2001Est. completion: Apr 20051,683 patients
Phase 3Completed
NCT00062595Eisaiphylloquinone

Vitamin K and Bone Turnover in Postmenopausal Women

Start: Sep 2000Est. completion: Oct 2004375 patients
Phase 3Completed

IMPACT Study (Improving Measurements of Persistence on "ACtonel" Treatment)

Start: Aug 1999
Phase 3Completed
NCT04708886AmgenRomosozumab

Romosozumab in Women With Chronic SCI

Start: Mar 2021Est. completion: Jun 202412 patients
Phase 2Completed

Phase 2 Dose-finding Study to Evaluate the Effects of BA058 in the Treatment of Postmenopausal Women With Osteoporosis

Start: Apr 2007Est. completion: Jun 2009
Phase 2Completed

Efficacy and Safety of AAE581 in Postmenopausal Women With Osteopenia/Osteoporosis.

Start: Mar 2005160 patients
Phase 2Completed

Safety and Efficacy of AAE581 in Postmenopausal Women With Osteoporosis

Start: Feb 2004Est. completion: Sep 2005676 patients
Phase 2Completed
NCT01005927AbbottFructooligosaccharide

Fructooligosaccharide and Calcium Absorption in Adolescent Girls

Start: Jan 2009Est. completion: Jun 200926 patients
Phase 1/2Completed
NCT04936984Radius Healthabaloparatide-sMTS

Study to Evaluate and Compare the Bioequivalence of Two Abaloparatide-sMTS Treatments in Healthy Women.

Start: Nov 2020Est. completion: Aug 2021
Phase 1Completed

Study of NaQuinate in Healthy Volunteers

Start: Jun 2019Est. completion: May 2020
Phase 1Unknown

Assessment of Anti-RANKL Antibody in Post-menopausal Women

Start: Aug 2017Est. completion: Dec 2018
Phase 1Unknown
NCT01833754AmgenRomosozumab

Study of Romosozumab (AMG 785) Administered to Healthy Participants and Patients With Stage 4 Renal Impairment or Stage 5 Renal Impairment Requiring Hemodialysis

Start: Apr 2013Est. completion: Feb 201424 patients
Phase 1Completed
NCT01634789PfizerBazedoxifene

A Pilot Bioavailability Study of 3 Test Tablet Formulations of Bazedoxifene Compared With A Reference Tablet Formulation of Bazedoxifene/Conjugated Estrogens in Healthy Postmenopausal Women

Start: Aug 2012Est. completion: Nov 20122 patients
Phase 1Terminated
NCT00846196Sanofirisedronate DR

A Study to Assess the Bioequivalence of Different Formulations of Risedronate in Healthy Male and Female Subjects

Start: Jan 2009Est. completion: May 2009538 patients
Phase 1Completed
NCT00745173PfizerBazedoxifene

Study Evaluating Premarin and Bazedoxifene Potential Interaction

Start: Sep 2008Est. completion: Oct 200830 patients
Phase 1Completed

Assess Bioequivalence of One 150 mg Risedronate Tablet Versus Two 75 mg Risedronate Tablets in Healthy Subjects

Start: Jan 2008Est. completion: Apr 200896 patients
Phase 1Completed
NCT00550303PfizerBazedoxifene

Study Comparing Formulations of Bazedoxifene/Conjugated Estrogens

Start: Oct 2007Est. completion: Nov 200728 patients
Phase 1Completed
NCT00550433PfizerBazedoxifene

Study Evaluating Bazedoxifene/CE in Postmenopausal Women

Start: Sep 2007Est. completion: Nov 2007
Phase 1Completed
NCT00479778PfizerBazedoxifene

Study Of Pharmacokinetic (PK) Profile of Bazedoxifene (BZA) in 2 BZA/Conjugated Estrogen Forms

Start: Apr 2007Est. completion: Jul 200772 patients
Phase 1Completed
NCT00465075PfizerBazedoxifene

Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations in Fed and Fasting in Healthy, Postmenopausal Women

Start: Mar 2007Est. completion: Apr 200724 patients
Phase 1Completed
NCT00464789PfizerBazedoxifene

Study Evaluating Bazedoxifene/Conjugated Estrogens Combinations In Healthy Postmenopausal Women

Start: Mar 2007Est. completion: May 2007
Phase 1Completed
NCT00396799PfizerBazedoxifene

Bioequivalence Study Of Bazedoxifene/Conjugated Estrogen Tablets In Postmenopausal Women

Start: Nov 2006Est. completion: Nov 2006
Phase 1Completed
NCT00986895AmgenControl group

A Study of Glyceryl Tri-(4-phenylbutyrate) Administered Orally as a Single Dose, and Twice Daily for Seven Consecutive Days to Subjects With Hepatic Impairment With Cirrhosis and to a Control Group

Start: Sep 2006Est. completion: Jun 200732 patients
Phase 1Completed
NCT00367536PfizerBazedoxifene

Study Evaluating Three Bazedoxifene/Conjugated Estrogens Combination Tablet Formulations Versus BZA Oral Solution

Start: Aug 2006Est. completion: Aug 200624 patients
Phase 1Completed

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

14 late-stage (Phase 3) programs — potential near-term approvals
23 companies competing in this space