Neuropathic Pain

Neurology
13
Pipeline Programs
9
Companies
11
Clinical Trials
4
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
5
0
2
0
0
6
Early DiscoveryClinical DevelopmentMarket

On Market (4)

Approved therapies currently available

U
CARNEXIVApproved
carbamazepine
Unknown Company
intravenous2016
Novartis
TEGRETOLApproved
carbamazepine
Novartis
Mood Stabilizer [EPC]oral1987
Novartis
TEGRETOL-XRApproved
carbamazepine
Novartis
Mood Stabilizer [EPC]oral1996
U
TERILApproved
carbamazepine
Unknown Company
Mood Stabilizer [EPC]oral2004

Competitive Landscape

9 companies ranked by most advanced pipeline stage

Novartis
NovartisBASEL, Switzerland
1 program
1
CarbamazepinePhase 41 trial
Active Trials
NCT01089855Completed123
Bausch Health
Bausch HealthQUEBEC, Quebec, Canada
1 program
1
nabilonePhase 41 trial
Active Trials
NCT00480181CompletedEst. Jul 2012
DS
Daiichi SankyoChina - Shanghai
1 program
1
DS-1971aPhase 21 trial
Active Trials
NCT02673866Withdrawn0Est. Feb 2017
Newron Pharmaceuticals
1 program
1
RalfinamidePhase 21 trial
Active Trials
NCT00736151Completed
Biogen
BiogenCAMBRIDGE, MA
2 programs
2
BIIB074Phase 11 trial
BIIB074Phase 11 trial
Active Trials
NCT02751905Completed6Est. May 2016
NCT02698267Completed16Est. Apr 2016
Relmada Therapeutics
Relmada TherapeuticsCORAL GABLES, FL
2 programs
2
REL-1017Phase 11 trial
REL-1017Phase 11 trial
Active Trials
NCT03637361CompletedEst. Jun 2015
NCT03638869CompletedEst. Nov 2015
Bial
BialPortugal - Coronado
1 program
1
MetforminPhase 11 trial
Active Trials
NCT00971295CompletedEst. Sep 2008
Abbott
AbbottABBOTT PARK, IL
1 program
Motor Cortex Stimulation using SJM EonC StimulatorN/A1 trial
Active Trials
NCT01554332Unknown38Est. Dec 2020
Pfizer
PfizerNEW YORK, NY
1 program
Neuropathic Pain DatabaseN/A1 trial
Active Trials
NCT00669006Completed789Est. Feb 2020

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
NovartisCarbamazepine
Bausch Healthnabilone
Daiichi SankyoDS-1971a
Newron PharmaceuticalsRalfinamide
BiogenBIIB074
BiogenBIIB074
Relmada TherapeuticsREL-1017
Relmada TherapeuticsREL-1017
BialMetformin
AbbottMotor Cortex Stimulation using SJM EonC Stimulator
PfizerNeuropathic Pain Database

Clinical Trials (11)

Total enrollment: 972 patients across 11 trials

NCT01089855NovartisCarbamazepine

Efficacy and Tolerability of Carbamazepine CR in Diabetic Neuropathy Pain

Start: Dec 2009123 patients
Phase 4Completed
NCT00480181Bausch Healthnabilone

Efficacy and Safety Evaluation of Nabilone as Adjunctive Therapy to Gabapentin for the Management of Neuropathic Pain in Multiple Sclerosis

Start: Jun 2007Est. completion: Jul 2012
Phase 4Completed
NCT02673866Daiichi SankyoDS-1971a

Study to Evaluate the Efficacy and Safety of DS-1971a for the Treatment of Diabetic Peripheral Neuropathic Pain (DPNP)

Start: Feb 2016Est. completion: Feb 20170
Phase 2Withdrawn
NCT00736151Newron PharmaceuticalsRalfinamide

Phase II Dose Titration Study in Patients With Neuropathic Pain

Start: May 2004
Phase 2Completed
NCT02751905BiogenBIIB074

Absorption, Metabolism, and Excretion Study of BIIB074

Start: Apr 2016Est. completion: May 20166 patients
Phase 1Completed
NCT02698267BiogenBIIB074

Effect of Itraconazole on the Pharmacokinetics of BIIB074

Start: Feb 2016Est. completion: Apr 201616 patients
Phase 1Completed
NCT03638869Relmada TherapeuticsREL-1017

Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of REL-1017 (d-Methadone)

Start: Aug 2015Est. completion: Nov 2015
Phase 1Completed
NCT03637361Relmada TherapeuticsREL-1017

Safety, Tolerability and Pharmacokinetics of Single Ascending Doses of REL-1017 (d-Methadone)

Start: Dec 2014Est. completion: Jun 2015
Phase 1Completed
NCT00971295BialMetformin

Effect of Eslicarbazepine Acetate on the Pharmacokinetics of Metformin in Healthy Volunteers

Start: Oct 2007Est. completion: Sep 2008
Phase 1Completed
NCT01554332AbbottMotor Cortex Stimulation using SJM EonC Stimulator

Motor Cortex Stimulation for Chronic Neuropathic Pain

Start: Oct 2012Est. completion: Dec 202038 patients
N/AUnknown
NCT00669006PfizerNeuropathic Pain Database

Neuropathic Pain Database

Start: Apr 2008Est. completion: Feb 2020789 patients
N/ACompleted

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

9 companies competing in this space

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