Generalized Pustular Psoriasis

Immunology
12
Pipeline Programs
4
Companies
14
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
5
0
5
1
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
9100%
+ 5 programs with unclassified modality

Competitive Landscape

4 companies ranked by most advanced pipeline stage

Boehringer Ingelheim
Boehringer IngelheimINGELHEIM, Germany
8 programs
3
2
1
SpesolimabPhase 4Monoclonal Antibody1 trial
spesolimabPhase 3Monoclonal Antibody1 trial
spesolimabPhase 3Monoclonal Antibody1 trial
SpesolimabPhase 2Monoclonal Antibody1 trial
SpesolimabPhase 2Monoclonal Antibody1 trial
+3 more programs
Active Trials
NCT05670821Completed52Est. Oct 2025
NCT06886009Not Yet Recruiting21Est. Jun 2029
NCT03886246Active Not Recruiting131Est. Apr 2028
+5 more trials
VP
Vanda PharmaceuticalsWASHINGTON, DC
3 programs
1
2
ImsidolimabPhase 3Monoclonal Antibody1 trial
Imsidolimab high dosePhase 31 trial
ImsidolimabPhase 2Monoclonal Antibody1 trial
Active Trials
NCT03619902Completed8Est. Jan 2021
NCT05366855Terminated42Est. Jul 2024
NCT05352893Completed45Est. Aug 2023
Takeda
TakedaTOKYO, Japan
1 program
1
TAK-279Phase 31 trial
Active Trials
NCT06323356Active Not Recruiting18Est. Jul 2026
CT
2 programs
1
1
TQH2929 InjectionsPhase 21 trial
TQH2929 InjectionPhase 11 trial
Active Trials
NCT06433531Active Not RecruitingEst. Dec 2025
NCT07314060Not Yet RecruitingEst. Jul 2027

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
2029
Boehringer IngelheimSpesolimab
TakedaTAK-279
Vanda PharmaceuticalsImsidolimab
Vanda PharmaceuticalsImsidolimab high dose
Boehringer Ingelheimspesolimab
Boehringer Ingelheimspesolimab
Chia Tai TianQing Pharmaceutical GroupTQH2929 Injections
Boehringer IngelheimSpesolimab
Boehringer IngelheimSpesolimab
Boehringer IngelheimSpesolimab
Vanda PharmaceuticalsImsidolimab
Chia Tai TianQing Pharmaceutical GroupTQH2929 Injection
Boehringer IngelheimSpevigo®
Boehringer IngelheimSpesolimab

Clinical Trials (14)

Total enrollment: 585 patients across 14 trials

A Study to Test Whether Spesolimab Helps People With Generalized Pustular Psoriasis (GPP) Who Need Treatment for Repeated Flares

Start: Oct 2023Est. completion: Aug 202642 patients
Phase 4Active Not Recruiting

A Study of TAK-279 in Adult Participants With Generalized Pustular Psoriasis or Erythrodermic Psoriasis

Start: Mar 2024Est. completion: Jul 202618 patients
Phase 3Active Not Recruiting

Long-Term Safety and Efficacy of Imsidolimab (ANB019) in Subjects With Generalized Pustular Psoriasis

Start: Apr 2022Est. completion: Jul 202442 patients
Phase 3Terminated

Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in the Treatment of Subjects With GPP

Start: Apr 2022Est. completion: Aug 202345 patients
Phase 3Completed

An Expanded Access Program in China to Provide Spesolimab to People With a Flare-up in Generalized Pustular Psoriasis Who Have no Other Treatment Options

Start: Mar 2022Est. completion: Jul 202339 patients
Phase 3Completed

An Expanded Access Trial in Japan to Provide Spesolimab to People With a Flare-up in Generalized Pustular Psoriasis Who Have no Other Treatment Options

Start: Feb 2022Est. completion: Mar 202311 patients
Phase 3Completed

A Clinical Trial of TQH2929 Injection in Patients With Acute Flare-up of Generalized Pustular Psoriasis

Start: Mar 2026Est. completion: Jul 2027
Phase 2Not Yet Recruiting

A Study to Test Whether BI 655130 (Spesolimab) Prevents Flare-ups in Patients With Generalized Pustular Psoriasis

Start: Jun 2020Est. completion: Nov 2022123 patients
Phase 2Completed

Effisayil™ ON: A Study to Test Long-term Treatment With Spesolimab in People With Generalized Pustular Psoriasis Who Took Part in a Previous Study

Start: May 2019Est. completion: Apr 2028131 patients
Phase 2Active Not Recruiting

Effisayil™ 1: A Study to Test Spesolimab (BI 655130) in Patients With a Flare-up of a Skin Disease Called Generalized Pustular Psoriasis

Start: Jan 2019Est. completion: Jan 202153 patients
Phase 2Completed

A Study to Evaluate the Efficacy and Safety of Imsidolimab (ANB019) in Adults With Generalized Pustular Psoriasis

Start: Jan 2019Est. completion: Jan 20218 patients
Phase 2Completed

A Clinical Study of TQH2929 Injection in Treatment With Generalized Pustular Psoriasis (GPP)

Start: Jun 2024Est. completion: Dec 2025
Phase 1Active Not Recruiting

Spesolimab Post-marketing Surveillance in Korean Patients With Flares With Generalized Pustular Psoriasis

Start: Mar 2026Est. completion: Jun 202921 patients
N/ANot Yet Recruiting

PMS of Spesolimab I.V. in GPP Patients With Acute Symptoms

Start: Apr 2023Est. completion: Oct 202552 patients
N/ACompleted

Related Jobs in Immunology

Phase Legend

PreclinicalLab & animal studies
Phase 1Safety & dosing
Phase 2Efficacy testing
Phase 3Large-scale trials
On MarketApproved & available

Key Insights

5 late-stage (Phase 3) programs — potential near-term approvals
Monoclonal Antibody is the dominant modality (100% of programs)
4 companies competing in this space