Fatty Liver
Metabolic Diseases
6
Pipeline Programs
6
Companies
5
Clinical Trials
2
Approved Products
Pipeline by Development Stage
Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
0
0
1
1
0
4
Early DiscoveryClinical DevelopmentMarket
Drug Modality Breakdown
Small Molecule
2100%
+ 4 programs with unclassified modality
On Market (2)
Approved therapies currently available
U
METFORMIN HYDROCHLORIDEApproved
metformin
Unknown Companyoral2018
U
XENICALApproved
orlistat
Unknown CompanyIntestinal Lipase Inhibitor [EPC]oral1999
Competitive Landscape
5 companies ranked by most advanced pipeline stage
M&
GS
Trial Timeline
Clinical trial activity over time
2021
2022
2023
2024
2025
2026
Pfizeratorvastatin
RocheOrlistat
Merck & Co.metformin
One BiosciencesAramchol
Gilead SciencesELF Test
Clinical Trials (5)
Total enrollment: 710 patients across 5 trials
Atorvastatin Versus Vitamin E in Treatment of Non-alcoholic Fatty Liver Disease
Start: May 2013Est. completion: Dec 2016120 patients
Phase 4Unknown
Orlistat (Xenical) in the Treatment of Overweight Patients With Nonalcoholic Steatohepatitis (NASH)
Start: Oct 2003Est. completion: Dec 200650 patients
Phase 4Completed
Metformin in Non-Alcoholic Fatty Liver Disease
Start: Nov 2004Est. completion: Jun 200890 patients
Phase 2/3Unknown
A Clinical Trial to Evaluate the Efficacy and Safety of Two Aramchol Doses Versus Placebo in Patients With NASH
Start: Apr 2015Est. completion: May 2018
Phase 2Completed
The Availability of the Enhanced Liver Fibrosis (ELF) Test Affects the Rate of Diagnosis of Nonalcoholic Steatohepatitis (NASH) With Fibrosis in Patients Referred to Hepatology
Start: Sep 2020Est. completion: Dec 2022450 patients
N/AUnknown
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Phase Legend
Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available
Key Insights
6 companies competing in this space