Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis

Immunology
3
Pipeline Programs
3
Companies
3
Clinical Trials
0
Approved Products

Pipeline by Development Stage

Preclinical
Phase 1
Phase 1/2
Phase 2
Phase 2/3
Phase 3
On Market
0
1
0
1
0
1
0
Early DiscoveryClinical DevelopmentMarket

Drug Modality Breakdown

Monoclonal Antibody
1100%
+ 2 programs with unclassified modality

Competitive Landscape

3 companies ranked by most advanced pipeline stage

Genentech
GenentechCA - Oceanside
1 program
1
RituximabPhase 3Monoclonal Antibody1 trial
Active Trials
NCT01697267Completed188Est. Nov 2019
NovelMed Therapeutics
NovelMed TherapeuticsOH - Cleveland
1 program
1
NM8074Phase 21 trial
Active Trials
NCT06226662Not Yet RecruitingEst. Sep 2028
Amgen
AmgenTHOUSAND OAKS, CA
1 program
1
CCX168Phase 11 trial
Active Trials
NCT06004947Completed32Est. Jun 2016

Trial Timeline

Clinical trial activity over time

2021
2022
2023
2024
2025
2026
2027
2028
GenentechRituximab
NovelMed TherapeuticsNM8074
AmgenCCX168

Clinical Trials (3)

Total enrollment: 220 patients across 3 trials

NCT01697267GenentechRituximab

Rituximab Vasculitis Maintenance Study

Start: Apr 2013Est. completion: Nov 2019188 patients
Phase 3Completed
NCT06226662NovelMed TherapeuticsNM8074

Study of NM8074 in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis (AAV)

Start: Jun 2026Est. completion: Sep 2028
Phase 2Not Yet Recruiting
NCT06004947AmgenCCX168

A Study in Healthy Volunteers to Evaluate the Drug-Drug Interaction Potential of CCX168 With Concomitant Medications

Start: Jan 2016Est. completion: Jun 201632 patients
Phase 1Completed

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Phase Legend

Preclinical— Lab & animal studies
Phase 1— Safety & dosing
Phase 2— Efficacy testing
Phase 3— Large-scale trials
On Market— Approved & available

Key Insights

1 late-stage (Phase 3) programs — potential near-term approvals
3 companies competing in this space

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